Staff

Director & PI

James A. Richardson, D.V.M., Ph.D., Diplomate (ACVP), is Director and Principal Investigator of the Molecular Pathology Core.

Dr. Richardson is Professor of Pathology and Molecular Biology, holder of the Minnie Stevens Piper Professorship, and a Distinguished Teaching Professor.

In addition to his teaching responsibilities and directing the Molecular Pathology Core, Dr. Richardson serves as:
- Course Director, MSII Pathology Course
- Subcommittee Chair, UT Southwestern Pre-Matriculation Basic Science
     Curriculum Advisor Committee
- Chairman, UT Southwestern Student Assistance Committee
- Member, UT Southwestern Medical School Admissions Committee
- Vice-Chairman, State of Texas Joint Admissions Medical Program
- Charter Member, Southwestern Academy of Teachers
- Member, UT Academy of Health Science Education

Research Interests

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Characterization of mutant phenotypes and the molecular basis of embryonic and neonatal development, as well as the study of models of heart disese and muscular disorders; utilizing gross pathology, routine histology, in-situ hybridization, and immunohistochemistry techniques. Clinical and research expertise in gross pathology/necropsy, histopathology, specialized microscopy, digital and 35mm imaging and analysis, desktop publishing and graphics.

Research Summary

- Characterization of the gene knockout phenotypes:
      Orexin, Insig-1, Capsulin, MyoR, CRP 1/2, Scleraxis, HRT-1/2/3,
      FBP-1, Nkx2.5, HSF-1/2, EVEC, Enothelins-a, b, 1, 2, 3, ECE-1/2,
      miRs-143/145, HDAC-1/2/3, dHand, eHand, Ets71, GATA-4/5
- Characterization of cholesterol synthesis pathway genes:
      SCALD, LDLR, VLDLR, ApoER2
- Characterization of the expression patterns of muscle specific genes:
      Myoglobin, FHL2, MNF, PKD1, MEF2c
- Characterization of the expression patterns of renal ischemia response
      genes: IRF-1, IL-6, G-CSF
- Characterization of cardiac hypertrophy phenotypes as a function of
      pressure overload or gene expression: CamKII, MLCK, PKD1,
      MEF2d, HDAC-1/2, STARS, SRF1, TRPC6
- Models of insulin resistance, glucose homeostasis, and adipose
      filling: STAT3, SREBP-1c, ET-1
- Efficacy of skin rejuvenation techniques and skin-filler/ lypolysis agents:
      1540nmEr laser, CO2 laser, hyaluronic acid
- Characterization of genetic point mutations resulting in myopathy:
      H6PD, MEF2c, RING-fp1/3
- Characterization of smooth muscle homeostasis genes:
      CRP-1/2, Fibulin-5, Dlx6, Tie-2

Awards

breadloaf

- Outstanding Teacher Award
       (UT Southwestern):
       Classes of 2012, 2011, 2009, 2005,
       2003, 2001, 2000, 1998, 1997,
       1995, 1993, 1991
- Teacher of the Year
       (University of Florida):
       Classes of 1985, 1984

Education

  • Ph.D.: Purdue University, West Lafayette, Indiana
  • D.V.M.: University of Guelph, Guelph, Ontario, Canada
  • Undergraduate: Trent University, Peterborough, Ontario, Canada