Grants

Grants

DatesPrincipal
Investigator(s)
Grant No./
Donor
TitleGoal
12/14-11/17 Dr. Mason RP140285 CPRIT-IIRA Noninvasive Identification of Prostate Tumor Hypoxia as a Prognostic Biomarker of Radiation Response To validate MOXI (MR Oximetry) as a measure of prostate tumor oxygenation and hypoxia and to use MOXI to identify tumors as hypoxic or oxygenated and demonstrate differential radiation doses required for tumor control.
12/14-11/17 Kevin Pinney, Ph.D. (Baylor University)
Local PI: Dr. Mason
RP 140399 CPRIT-IIRA; Subcontract from Baylor University Targeting Hypoxia in Breast Cancer with Highly Potent Small-Molecule Anticancer Prodrugs To confirm, map, and quantitate hypoxic regions of tumors in animal models for breast cancer to identify tumor types exhibiting well defined levels of hypoxia and in vivo evaluation of the two most promising BAPCs (determined at Baylor) for efficacy in reducing breast cancer tumor burden in two animal models.
6/12-4/17 Dr. Mason RP120670-P3, CPRIT P3: Effects of Hypoxia To evaluate tumor oxygenation in pre-clinical models and translate measurements to human lung cancer patients. Assess the ability to determine hypoxia, modulate hypoxia, and enhance radiation response.
6/11-4/16 Dr. Mason RP110441-C1, CPRIT C1: In Vivo Imaging Core To engineer enhanced antibodies for improved targeting of tumor associated phosphatidylserine – the core is responsible for pharmacokinetics and imaging.
8/10-7/15 James K.V. Willson, M.D. P30 CA142543-01, NIH/NCI Cancer Center Support Grant Provide Infrastructure support.
Role: Small animal imaging resource director
6/10-3/15 Kevin G. Pinney, Ph.D. (Baylor University);
Dr. Mason
1 R01 CA140674-01, NIH/NCI; Subcontract with Baylor Discovery and development of improved chemotherapeutic agents with enhanced selectivity for the tumor microenvironment Evaluation of novel vasculature disrupting agents.
1/10-12/14 Dr. Mason R01 CA139043-01A1, NIH/NCI Hypoxia and radiotherapy: Evaluation and mitigation in tumors Develop a prognostic test to reveal tumor hypoxia.