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Publications

Publications

Loss of the liver X receptor LXRα/β in peripheral sensory neurons modifies energy expenditure.
Mansuy-Aubert V, Gautron L, Lee S, Bookout AL, Kusminski C, Sun K, Zhang Y, Scherer PE, Mangelsdorf DJ, Elmquist JK. Elife. 2015 Jun 15;4. doi: 10.7554/eLife.06667. PMID:26076474

Bile Acids as Hormones: The FXR-FGF15/19 Pathway. Kliewer SA, Mangelsdorf DJ.
Dig Dis. 2015;33(3):327-31. doi: 10.1159/000371670. Epub 2015 May 27. PMID:26045265

Reflections on the field of metabolism. Moller DE, Cuervo AM, Gordon J, Froguel P, Mangelsdorf DJ. Cell Metab. 2015 Apr 7;21(4):505-6. No abstract available.  PMID:26042242

Detection of FGF15 in Plasma by Stable Isotope Standards and Capture by Anti-peptide Antibodies and Targeted Mass Spectrometry. Katafuchi T, Esterházy D, Lemoff A, Ding X, Sondhi V, Kliewer SA, Mirzaei H, Mangelsdorf DJ.Cell Metab. 2015 Jun 2;21(6):898-904. doi: 10.1016/j.cmet.2015.05.004. PMID:26039452

Nuclear receptor PXR: discovery of a pharmaceutical anti-target. Kliewer SA. J Clin Invest. 2015 Apr;125(4):1388-9. doi: 10.1172/JCI81244. Epub 2015 Apr 1. PMID:25831443

The nuclear receptor DAF-12 regulates nutrient metabolism and reproductive growth in nematodes. Wang Z, Stoltzfus J, You YJ, Ranjit N, Tang H, Xie Y, Lok JB, Mangelsdorf DJ, Kliewer SA. PLoS Genet. 2015 Mar 16;11(3):e1005027. doi: 10.1371/journal.pgen.1005027. eCollection 2015 Mar. PMID:25774872

Glucocorticoids regulate the metabolic hormone FGF21 in a feed-forward loop.
Patel R, Bookout AL, Magomedova L, Owen BM, Consiglio GP, Shimizu M, Zhang Y, Mangelsdorf DJ, Kliewer SA, Cummins CL. Mol Endocrinol. 2015 Feb;29(2):213-23. doi: 10.1210/me.2014-1259. Epub 2014 Dec 11. PMID:25495872

SnapShot: Hormones of the gastrointestinal tract. Coate KC, Kliewer SA, Mangelsdorf DJ.
Cell. 2014 Dec 4;159(6):1478.e1. doi: 10.1016/j.cell.2014.11.026. PMID:25480303

Tissue-specific actions of the metabolic hormones FGF15/19 and FGF21. Owen BM, Mangelsdorf DJ, Kliewer SA. Trends Endocrinol Metab. 2015 Jan;26(1):22-9. doi: 10.1016/j.tem.2014.10.002. Epub 2014 Dec 1. PMID:25476453

FGF21 acts centrally to induce sympathetic nerve activity, energy expenditure, and weight loss.
Owen BM, Ding X, Morgan DA, Coate KC, Bookout AL, Rahmouni K, Kliewer SA, Mangelsdorf DJ. Cell Metab. 2014 Oct 7;20(4):670-7. doi: 10.1016/j.cmet.2014.07.012. Epub 2014 Aug 14. PMID:25130400

Circulating FGF21 is liver derived and enhances glucose uptake during refeeding and overfeeding. Markan KR, Naber MC, Ameka MK, Anderegg MD, Mangelsdorf DJ, Kliewer SA, Mohammadi M, Potthoff MJ. Diabetes. 2014 Dec;63(12):4057-63. doi: 10.2337/db14-0595. Epub 2014 Jul 9. PMID:25008183

PPARγ in vagal neurons regulates high-fat diet induced thermogenesis. Liu C, Bookout AL, Lee S, Sun K, Jia L, Lee C, Udit S, Deng Y, Scherer PE, Mangelsdorf DJ, Gautron L, Elmquist JK.
Cell Metab. 2014 Apr 1;19(4):722-30. doi: 10.1016/j.cmet.2014.01.021. PMID:24703703

Nuclear Receptors, RXR, and the Big Bang. Evans RM, Mangelsdorf DJ. Cell. 2014 Mar 27;157(1):255-66. doi: 10.1016/j.cell.2014.03.012. Review. PMID:24679540

Structural insights into gene repression by the orphan nuclear receptor SHP.
Zhi X, Zhou XE, He Y, Zechner C, Suino-Powell KM, Kliewer SA, Melcher K, Mangelsdorf DJ, Xu HE. Proc Natl Acad Sci U S A. 2014 Jan 14;111(2):839-44. doi: 10.1073/pnas.1322827111. Epub 2013 Dec 30. Erratum in: Proc Natl Acad Sci U S A. 2014 Mar 11;111(10):3895.  PMID:24379397

FGF21 regulates metabolism and circadian behavior by acting on the nervous system.
Bookout AL, de Groot MH, Owen BM, Lee S, Gautron L, Lawrence HL, Ding X, Elmquist JK, Takahashi JS, Mangelsdorf DJ, Kliewer SA. Nat Med. 2013 Sep;19(9):1147-52. doi: 10.1038/nm.3249. Epub 2013 Aug 11. PMID:23933984

FGF21 contributes to neuroendocrine control of female reproduction.
Owen BM, Bookout AL, Ding X, Lin VY, Atkin SD, Gautron L, Kliewer SA, Mangelsdorf DJ.
Nat Med. 2013 Sep;19(9):1153-6. doi: 10.1038/nm.3250. Epub 2013 Aug 11. PMID:23933983

Nuclear receptor LRH-1 induces the reproductive neuropeptide kisspeptin in the hypothalamus. Atkin SD, Owen BM, Bookout AL, Cravo RM, Lee C, Elias CF, Elmquist JK, Kliewer SA, Mangelsdorf DJ. Mol Endocrinol. 2013 Apr;27(4):598-605. doi: 10.1210/me.2012-1371. Epub 2013 Mar 15. PMID:23504956

Metabolic hormone FGF21 is induced in ground squirrels during hibernation but its overexpression is not sufficient to cause torpor. Nelson BT, Ding X, Boney-Montoya J, Gerard RD, Kliewer SA, Andrews MT. PLoS One. 2013;8(1):e53574. doi: 10.1371/journal.pone.0053574. Epub 2013 Jan 2. PMID:23301087

Colesevelam suppresses hepatic glycogenolysis by TGR5-mediated induction of GLP-1 action in DIO mice. Potthoff MJ, Potts A, He T, Duarte JA, Taussig R, Mangelsdorf DJ, Kliewer SA, Burgess SC. Am J Physiol Gastrointest Liver Physiol. 2013 Feb 15;304(4):G371-80.doi:10.1152/ajpgi.00400.2012. Epub 2012 Dec 20. PMID:23257920

The starvation hormone, fibroblast growth factor-21, extends lifespan in mice. Zhang Y, Xie Y, Berglund ED, Coate KC, He TT, Katafuchi T, Xiao G, Potthoff MJ, Wei W, Wan Y, Yu RT, Evans RM, Kliewer SA, Mangelsdorf DJ. Elife. 2012Oct15;1:e00065.doi:10.7554/eLife.00065. PMID:23066506

Nuclear receptors HNF4α and LRH-1 cooperate in regulating Cyp7a1 in vivo. Kir S, Zhang Y, Gerard RD, Kliewer SA, Mangelsdorf DJ. J Biol Chem. 2012 Nov 30;287(49):41334-41. doi: 10.1074/jbc.M112.421834. Epub 2012 Oct 4. PMID:23038264

βKlotho is required for fibroblast growth factor 21 effects on growth and metabolism.
Ding X, Boney-Montoya J, Owen BM, Bookout AL, Coate KC, Mangelsdorf DJ, Kliewer SA.
Cell Metab. 2012 Sep 5;16(3):387-93. doi: 10.1016/j.cmet.2012.08.002. PMID:22958921

Sterol-dependent nuclear import of ORP1S promotes LXR regulated trans-activation of apoE.
Lee S, Wang PY, Jeong Y, Mangelsdorf DJ, Anderson RG, Michaely P. Exp Cell Res. 2012 Oct 1;318(16):2128-42. doi: 10.1016/j.yexcr.2012.06.012. Epub 2012 Jun 20. PMID:22728266

Research resource: Diagnostic and therapeutic potential of nuclear receptor expression in lung cancer. Jeong Y, Xie Y, Lee W, Bookout AL, Girard L, Raso G, Behrens C, Wistuba II, Gadzar AF, Minna JD, Mangelsdorf DJ. Mol Endocrinol. 2012 Aug;26(8):1443-54. doi: 10.1210/me.2011-1382. Epub 2012 Jun 14. PMID:22700587

Liver LXRα expression is crucial for whole body cholesterol homeostasis and reverse cholesterol transport in mice. Zhang Y, Breevoort SR, Angdisen J, Fu M, Schmidt DR, Holmstrom SR, Kliewer SA, Mangelsdorf DJ, Schulman IG. J Clin Invest. 2012 May;122(5):1688-99. doi: 10.1172/JCI59817. Epub 2012 Apr 9. PMID:22484817

Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor γ. Wei W, Dutchak PA, Wang X, Ding X, Wang X, Bookout AL, Goetz R, Mohammadi M, Gerard RD, Dechow PC, Mangelsdorf DJ, Kliewer SA, Wan Y.
Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):3143-8. doi: 10.1073/pnas.1200797109. Epub 2012 Feb 6. PMID:22315431

Fibroblast growth factor-21 regulates PPARγ activity and the antidiabetic actions of thiazolidinediones. Dutchak PA, Katafuchi T, Bookout AL, Choi JH, Yu RT, Mangelsdorf DJ, Kliewer SA. Cell. 2012 Feb 3;148(3):556-67. doi: 10.1016/j.cell.2011.11.062. PMID:22304921

Endocrine fibroblast growth factors 15/19 and 21: from feast to famine. Potthoff MJ, Kliewer SA, Mangelsdorf DJ. Genes Dev. 2012 Feb 15;26(4):312-24. doi: 10.1101/gad.184788.111. Epub 2012 Feb 2. Review. PMID:22302876

Structural conservation of ligand binding reveals a bile acid-like signaling pathway in nematodes. Zhi X, Zhou XE, Melcher K, Motola DL, Gelmedin V, Hawdon J, Kliewer SA, Mangelsdorf DJ, Xu HE. J Biol Chem. 2012 Feb 10;287(7):4894-903. doi: 10.1074/jbc.M111.315242. Epub 2011 Dec 14. PMID:22170062

LRH-1 and PTF1-L coregulate an exocrine pancreas-specific transcriptional network for digestive function. Holmstrom SR, Deering T, Swift GH, Poelwijk FJ, Mangelsdorf DJ, Kliewer SA, MacDonald RJ. Genes Dev. 2011 Aug 15;25(16):1674-9. doi: 10.1101/gad.16860911. PMID:21852532

Roles of FGF19 in liver metabolism.Kir S, Kliewer SA, Mangelsdorf DJ. Cold Spring Harb Symp Quant Biol. 2011;76:139-44. doi: 10.1101/sqb.2011.76.010710. Epub 2011 Aug 3. Review. PMID:21813638

The Rieske oxygenase DAF-36 functions as a cholesterol 7-desaturase in steroidogenic pathways governing longevity. Wollam J, Magomedova L, Magner DB, Shen Y, Rottiers V, Motola DL, Mangelsdorf DJ, Cummins CL, Antebi A. Aging Cell. 2011 Oct;10(5):879-84. doi: 10.1111/j.1474-9726.2011.00733.x. Epub 2011 Aug 7. PMID:21749634

FGF15/19 regulates hepatic glucose metabolism by inhibiting the CREB-PGC-1α pathway.
Potthoff MJ, Boney-Montoya J, Choi M, He T, Sunny NE, Satapati S, Suino-Powell K, Xu HE, Gerard RD, Finck BN, Burgess SC, Mangelsdorf DJ, Kliewer SA. Cell Metab. 2011 Jun 8;13(6):729-38. doi: 10.1016/j.cmet.2011.03.019. PMID:21641554

The G protein-coupled bile acid receptor, TGR5, stimulates gallbladder filling.
Li T, Holmstrom SR, Kir S, Umetani M, Schmidt DR, Kliewer SA, Mangelsdorf DJ.
Mol Endocrinol. 2011 Jun;25(6):1066-71. doi: 10.1210/me.2010-0460. Epub 2011 Mar 31. PMID:21454404

FGF19 as a postprandial, insulin-independent activator of hepatic protein and glycogen synthesis. Kir S, Beddow SA, Samuel VT, Miller P, Previs SF, Suino-Powell K, Xu HE, Shulman GI, Kliewer SA, Mangelsdorf DJ. Science. 2011 Mar 25;331(6024):1621-4. doi: 10.1126/science.1198363. PMID:21436455

AKR1B7 is induced by the farnesoid X receptor and metabolizes bile acids. Schmidt DR, Schmidt S, Holmstrom SR, Makishima M, Yu RT, Cummins CL, Mangelsdorf DJ, Kliewer SA. J Biol Chem. 2011 Jan 28;286(4):2425-32. doi: 10.1074/jbc.M110.181230. Epub 2010 Nov 16. PMID:21081494

Nuclear receptor expression defines a set of prognostic biomarkers for lung cancer.
Jeong Y, Xie Y, Xiao G, Behrens C, Girard L, Wistuba II, Minna JD, Mangelsdorf DJ.
PLoS Med. 2010 Dec 14;7(12):e1000378. doi: 10.1371/journal.pmed.1000378. PMID:21179495

LXRβ is required for glucocorticoid-induced hyperglycemia and hepatosteatosis in mice.
Patel R, Patel M, Tsai R, Lin V, Bookout AL, Zhang Y, Magomedova L, Li T, Chan JF, Budd C, Mangelsdorf DJ, Cummins CL. J Clin Invest. 2011 Jan;121(1):431-41. doi: 10.1172/JCI41681. Epub 2010 Dec 1. PMID:21123945

Commentary: the year in nuclear receptor control of metabolism. Mangelsdorf DJ.
Mol Endocrinol. 2010 Nov;24(11):2075-80. doi: 10.1210/me.2010-0357. Epub 2010 Sep 29. PMID:20880985

Research resource: Comprehensive expression atlas of the fibroblast growth factor system in adult mouse. Fon Tacer K, Bookout AL, Ding X, Kurosu H, John GB, Wang L, Goetz R, Mohammadi M, Kuro-o M, Mangelsdorf DJ, Kliewer SA. Mol Endocrinol. 2010 Oct;24(10):2050-64. doi: 10.1210/me.2010-0142. Epub 2010 Jul 28. PMID:20667984

Expression profiling of nuclear receptors in the NCI60 cancer cell panel reveals receptor-drug and receptor-gene interactions. Holbeck S, Chang J, Best AM, Bookout AL, Mangelsdorf DJ, Martinez ED. Mol Endocrinol. 2010 Jun;24(6):1287-96. doi: 10.1210/me.2010-0040. Epub 2010 Apr 7. PMID:20375240

Regulation of bile acid synthesis by fat-soluble vitamins A and D. Schmidt DR, Holmstrom SR, Fon Tacer K, Bookout AL, Kliewer SA, Mangelsdorf DJ. J Biol Chem. 2010 May 7;285(19):14486-94. doi: 10.1074/jbc.M110.116004. Epub 2010 Mar 16. PMID:20233723

Fibroblast growth factor 21: from pharmacology to physiology. Kliewer SA, Mangelsdorf DJ. Am J Clin Nutr. 2010 Jan;91(1):254S-257S. doi: 10.3945/ajcn.2009.28449B. Epub 2009 Nov 11. Review. PMID:19906798

Nuclear receptor regulation of stemness and stem cell differentiation. Jeong Y, Mangelsdorf DJ. Exp Mol Med. 2009 Aug 31;41(8):525-37. doi: 10.3858/emm.2009.41.8.091. Review. PMID:19696553

Chronic diarrhea due to excessive bile acid synthesis and not defective ileal transport: a new syndrome of defective fibroblast growth factor 19 release. Hofmann AF, Mangelsdorf DJ, Kliewer SA. Clin Gastroenterol Hepatol. 2009 Nov;7(11):1151-4. doi: 10.1016/j.cgh.2009.07.026. Epub 2009 Aug 7. No abstract available.  PMID:19665580

FGF21 induces PGC-1alpha and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response. Potthoff MJ, Inagaki T, Satapati S, Ding X, He T, Goetz R, Mohammadi M, Finck BN, Mangelsdorf DJ, Kliewer SA, Burgess SC. Proc Natl Acad Sci U S A. 2009 Jun 30;106(26):10853-8. doi: 10.1073/pnas.0904187106. Epub 2009 Jun 16. PMID:19541642

Identification of the nuclear receptor DAF-12 as a therapeutic target in parasitic nematodes.

Wang Z, Zhou XE, Motola DL, Gao X, Suino-Powell K, Conneely A, Ogata C, Sharma KK, Auchus RJ, Lok JB, Hawdon JM, Kliewer SA, Xu HE, Mangelsdorf DJ. Proc Natl Acad Sci U S A. 2009 Jun 9;106(23):9138-43. doi: 10.1073/pnas.0904064106. Epub 2009 Jun 2. PMID:19497877

Minireview: Evolution of NURSA, the Nuclear Receptor Signaling Atlas. McKenna NJ, Cooney AJ, DeMayo FJ, Downes M, Glass CK, Lanz RB, Lazar MA, Mangelsdorf DJ, Moore DD, Qin J, Steffen DL, Tsai MJ, Tsai SY, Yu R, Margolis RN, Evans RM, O'Malley BW. Mol Endocrinol. 2009 Jun;23(6):740-6. doi: 10.1210/me.2009-0135. Epub 2009 May 7. Review. Erratum in: Mol Endocrinol. 2009 Sep;23(9):1522.  PMID:19423650

Nuclear hormone receptor regulation of microRNAs controls developmental progression.
Bethke A, Fielenbach N, Wang Z, Mangelsdorf DJ, Antebi A. Science. 2009 Apr 3;324(5923):95-8. doi: 10.1126/science.1164899. PMID:19342589

MicroRNA let-7 regulates 3T3-L1 adipogenesis. Sun T, Fu M, Bookout AL, Kliewer SA, Mangelsdorf DJ. Mol Endocrinol. 2009 Jun;23(6):925-31. doi: 10.1210/me.2008-0298. Epub 2009 Mar 26. Erratum in: Mol Endocrinol. 2009 Sep;23(9):1522.  PMID:19324969

Synthesis and activity of dafachronic acid ligands for the C. elegans DAF-12 nuclear hormone receptor. Sharma KK, Wang Z, Motola DL, Cummins CL, Mangelsdorf DJ, Auchus RJ.
Mol Endocrinol. 2009 May;23(5):640-8. doi: 10.1210/me.2008-0415. Epub 2009 Feb 5. PMID:19196833

Expression profiling of nuclear receptors in human and mouse embryonic stem cells. Xie CQ, Jeong Y, Fu M, Bookout AL, Garcia-Barrio MT, Sun T, Kim BH, Xie Y, Root S, Zhang J, Xu RH, Chen YE, Mangelsdorf DJ. Mol Endocrinol. 2009 May;23(5):724-33. doi: 10.1210/me.2008-0465. Epub 2009 Feb 5. PMID:19196830

Nuclear receptors of the enteric tract: guarding the frontier. Schmidt DR, Mangelsdorf DJ.
Nutr Rev. 2008 Oct;66(10 Suppl 2):S88-97. doi: 10.1111/j.1753-4887.2008.00092.x. Review. PMID:18844851

Structural basis of human pregnane X receptor activation by the hops constituent colupulone.
Teotico DG, Bischof JJ, Peng L, Kliewer SA, Redinbo MR. Mol Pharmacol. 2008 Dec;74(6):1512-20. doi: 10.1124/mol.108.050732. Epub 2008 Sep 2. PMID:18768384

Inhibition of growth hormone signaling by the fasting-induced hormone FGF21. Inagaki T, Lin VY, Goetz R, Mohammadi M, Mangelsdorf DJ, Kliewer SA. Cell Metab. 2008 Jul;8(1):77-83. doi: 10.1016/j.cmet.2008.05.006. PMID:18585098

Partial resistance to peroxisome proliferator-activated receptor-alpha agonists in ZDF rats is associated with defective hepatic mitochondrial metabolism. Satapati S, He T, Inagaki T, Potthoff M, Merritt ME, Esser V, Mangelsdorf DJ, Kliewer SA, Browning JD, Burgess SC.
Diabetes. 2008 Aug;57(8):2012-21. doi: 10.2337/db08-0226. Epub 2008 May 9. PMID:18469201

Liver receptor homolog-1 regulates bile acid homeostasis but is not essential for feedback regulation of bile acid synthesis. Lee YK, Schmidt DR, Cummins CL, Choi M, Peng L, Zhang Y, Goodwin B, Hammer RE, Mangelsdorf DJ, Kliewer SA. Mol Endocrinol. 2008 Jun;22(6):1345-56. doi: 10.1210/me.2007-0565. Epub 2008 Mar 6. PMID:18323469

High-throughput real-time quantitative reverse transcription PCR. Bookout AL, Cummins CL, Mangelsdorf DJ, Pesola JM, Kramer MF. Curr Protoc Mol Biol. 2006 Feb;Chapter 15:Unit 15.8. doi: 10.1002/0471142727.mb1508s73. PMID:18265376

Liver X receptor alpha is a transcriptional repressor of the uncoupling protein 1 gene and the brown fat phenotype. Wang H, Zhang Y, Yehuda-Shnaidman E, Medvedev AV, Kumar N, Daniel KW, Robidoux J, Czech MP, Mangelsdorf DJ, Collins S. Mol Cell Biol. 2008 Apr;28(7):2187-200. doi: 10.1128/MCB.01479-07. Epub 2008 Jan 14. PMID:18195045

Overexpression of pyruvate dehydrogenase kinase 4 in heart perturbs metabolism and exacerbates calcineurin-induced cardiomyopathy. Zhao G, Jeoung NH, Burgess SC, Rosaaen-Stowe KA, Inagaki T, Latif S, Shelton JM, McAnally J, Bassel-Duby R, Harris RA, Richardson JA, Kliewer SA. Am J Physiol Heart Circ Physiol. 2008 Feb;294(2):H936-43. Epub 2007 Dec 14. PMID:18083902

Synthesis, characterization, and receptor interaction profiles of enantiomeric bile acids.
Katona BW, Cummins CL, Ferguson AD, Li T, Schmidt DR, Mangelsdorf DJ, Covey DF.
J Med Chem. 2007 Nov 29;50(24):6048-58. Epub 2007 Oct 27. PMID:17963371

27-Hydroxycholesterol is an endogenous SERM that inhibits the cardiovascular effects of estrogen. Umetani M, Domoto H, Gormley AK, Yuhanna IS, Cummins CL, Javitt NB, Korach KS, Shaul PW, Mangelsdorf DJ. Nat Med. 2007 Oct;13(10):1185-92. Epub 2007 Sep 16. PMID:17873880

27-hydroxycholesterol is an endogenous selective estrogen receptor modulator. DuSell CD, Umetani M, Shaul PW, Mangelsdorf DJ, McDonnell DP. Mol Endocrinol. 2008 Jan;22(1):65-77. Epub 2007 Sep 13. PMID:17872378

FXR agonists and FGF15 reduce fecal bile acid excretion in a mouse model of bile acid malabsorption. Jung D, Inagaki T, Gerard RD, Dawson PA, Kliewer SA, Mangelsdorf DJ, Moschetta A. J Lipid Res. 2007 Dec;48(12):2693-700. Epub 2007 Sep 6. PMID:17823457

Cardiac peroxisome proliferator-activated receptor gamma is essential in protecting cardiomyocytes from oxidative damage. Ding G, Fu M, Qin Q, Lewis W, Kim HW, Fukai T, Bacanamwo M, Chen YE, Schneider MD, Mangelsdorf DJ, Evans RM, Yang Q. Cardiovasc Res. 2007 Nov 1;76(2):269-79. Epub 2007 Jul 4. PMID:17678635

Differential regulation of bile acid homeostasis by the farnesoid X receptor in liver and intestine.
Kim I, Ahn SH, Inagaki T, Choi M, Ito S, Guo GL, Kliewer SA, Gonzalez FJ. J Lipid Res. 2007 Dec;48(12):2664-72. Epub 2007 Aug 24. PMID:17720959

Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21. Kurosu H, Choi M, Ogawa Y, Dickson AS, Goetz R, Eliseenkova AV, Mohammadi M, Rosenblatt KP, Kliewer SA, Kuro-o M. J Biol Chem. 2007 Sep 14;282(37):26687-95. Epub 2007 Jul 10. PMID:17623664

Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21. Inagaki T, Dutchak P, Zhao G, Ding X, Gautron L, Parameswara V, Li Y, Goetz R, Mohammadi M, Esser V, Elmquist JK, Gerard RD, Burgess SC, Hammer RE, Mangelsdorf DJ, Kliewer SA. Cell Metab. 2007 Jun;5(6):415-25. PMID:17550777

In vivo imaging of farnesoid X receptor activity reveals the ileum as the primary bile acid signaling tissue. Houten SM, Volle DH, Cummins CL, Mangelsdorf DJ, Auwerx J. Mol Endocrinol. 2007 Jun;21(6):1312-23. Epub 2007 Apr 10. PMID:17426284

A bile acid-like steroid modulates Caenorhabditis elegans lifespan through nuclear receptor signaling. Gerisch B, Rottiers V, Li D, Motola DL, Cummins CL, Lehrach H, Mangelsdorf DJ, Antebi A. Proc Natl Acad Sci U S A. 2007 Mar 20;104(12):5014-9. Epub 2007 Mar 14. PMID:17360327

Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members. Goetz R, Beenken A, Ibrahimi OA, Kalinina J, Olsen SK, Eliseenkova AV, Xu C, Neubert TA, Zhang F, Linhardt RJ, Yu X, White KE, Inagaki T, Kliewer SA, Yamamoto M, Kurosu H, Ogawa Y, Kuro-o M, Lanske B, Razzaque MS, Mohammadi M.
Mol Cell Biol. 2007 May;27(9):3417-28. Epub 2007 Mar 5. PMID:17339340

Functional interactions between the Moses corepressor and DHR78 nuclear receptor regulate growth in Drosophila. Baker KD, Beckstead RB, Mangelsdorf DJ, Thummel CS. Genes Dev. 2007 Feb 15;21(4):450-64. PMID:17322404

Activation of LXRs prevents bile acid toxicity and cholestasis in female mice. Uppal H, Saini SP, Moschetta A, Mu Y, Zhou J, Gong H, Zhai Y, Ren S, Michalopoulos GK, Mangelsdorf DJ, Xie W. Hepatology. 2007 Feb;45(2):422-32. PMID:17256725

Enzymatic reduction of oxysterols impairs LXR signaling in cultured cells and the livers of mice.
Chen W, Chen G, Head DL, Mangelsdorf DJ, Russell DW. Cell Metab. 2007 Jan;5(1):73-9. PMID:17189208

Crystal structure of the pregnane X receptor-estradiol complex provides insights into endobiotic recognition. Xue Y, Moore LB, Orans J, Peng L, Bencharit S, Kliewer SA, Redinbo MR.
Mol Endocrinol. 2007 May;21(5):1028-38. Epub 2007 Feb 27. Erratum in: Mol Endocrinol. 2007 Jun;21(6):1488-9. PMID:17327420

International Union of Pharmacology. LXIII. Retinoid X receptors. Germain P, Chambon P, Eichele G, Evans RM, Lazar MA, Leid M, De Lera AR, Lotan R, Mangelsdorf DJ, Gronemeyer H. Pharmacol Rev. 2006 Dec;58(4):760-72. Review. PMID:17132853

International Union of Pharmacology. LXII. The NR1H and NR1I receptors: constitutive androstane receptor, pregnene X receptor, farnesoid X receptor alpha, farnesoid X receptor beta, liver X receptor alpha, liver X receptor beta, and vitamin D receptor. Moore DD, Kato S, Xie W, Mangelsdorf DJ, Schmidt DR, Xiao R, Kliewer SA. Pharmacol Rev. 2006 Dec;58(4):742-59. Review. PMID:17132852

Liver X receptors and cholesterol homoeostasis: spotlight on the adrenal gland. Cummins CL, Mangelsdorf DJ. Biochem Soc Trans. 2006 Dec;34(Pt 6):1110-3. Review. PMID:17073762

Identification of a hormonal basis for gallbladder filling. Choi M, Moschetta A, Bookout AL, Peng L, Umetani M, Holmstrom SR, Suino-Powell K, Xu HE, Richardson JA, Gerard RD, Mangelsdorf DJ, Kliewer SA. Nat Med. 2006 Nov;12(11):1253-5. Epub 2006 Oct 29. PMID:17072310

Nuclear receptor expression links the circadian clock to metabolism. Yang X, Downes M, Yu RT, Bookout AL, He W, Straume M, Mangelsdorf DJ, Evans RM. Cell. 2006 Aug 25;126(4):801-10. PMID:16923398

Anatomical profiling of nuclear receptor expression reveals a hierarchical transcriptional network. Bookout AL, Jeong Y, Downes M, Yu RT, Evans RM, Mangelsdorf DJ. Cell. 2006 Aug 25;126(4):789-99. PMID:16923397

Sterol intermediates from cholesterol biosynthetic pathway as liver X receptor ligands.
Yang C, McDonald JG, Patel A, Zhang Y, Umetani M, Xu F, Westover EJ, Covey DF, Mangelsdorf DJ, Cohen JC, Hobbs HH. J Biol Chem. 2006 Sep 22;281(38):27816-26. Epub 2006 Jul 20. PMID:16857673

Liver X receptors regulate adrenal cholesterol balance. Cummins CL, Volle DH, Zhang Y, McDonald JG, Sion B, Lefrançois-Martinez AM, Caira F, Veyssière G, Mangelsdorf DJ, Lobaccaro JM. J Clin Invest. 2006 Jul;116(7):1902-12. PMID:16823488

Pregnane X receptor is a target of farnesoid X receptor. Jung D, Mangelsdorf DJ, Meyer UA.
J Biol Chem. 2006 Jul 14;281(28):19081-91. Epub 2006 May 8. PMID:16682417

Quantitative real-time PCR protocol for analysis of nuclear receptor signaling pathways.
Bookout AL, Mangelsdorf DJ. Nucl Recept Signal. 2003;1:e012. Epub 2003 Dec 23. PMID:16604184

Hormonal control of C. elegans dauer formation and life span by a Rieske-like oxygenase.
Rottiers V, Motola DL, Gerisch B, Cummins CL, Nishiwaki K, Mangelsdorf DJ, Antebi A.
Dev Cell. 2006 Apr;10(4):473-82. Epub 2006 Mar 23. PMID:16563875

Identification of ligands for DAF-12 that govern dauer formation and reproduction in C. elegans.
Motola DL, Cummins CL, Rottiers V, Sharma KK, Li T, Li Y, Suino-Powell K, Xu HE, Auchus RJ, Antebi A, Mangelsdorf DJ. Cell. 2006 Mar 24;124(6):1209-23. Epub 2006 Mar 9. PMID:16529801

Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor.
Inagaki T, Moschetta A, Lee YK, Peng L, Zhao G, Downes M, Yu RT, Shelton JM, Richardson JA, Repa JJ, Mangelsdorf DJ, Kliewer SA. Proc Natl Acad Sci U S A. 2006 Mar 7;103(10):3920-5. Epub 2006 Feb 10. PMID:16473946

LXRS and FXR: the yin and yang of cholesterol and fat metabolism. Kalaany NY, Mangelsdorf DJ. Annu Rev Physiol. 2006;68:159-91. Review. PMID:16460270

Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis. Inagaki T, Choi M, Moschetta A, Peng L, Cummins CL, McDonald JG, Luo G, Jones SA, Goodwin B, Richardson JA, Gerard RD, Repa JJ, Mangelsdorf DJ, Kliewer SA.
Cell Metab. 2005 Oct;2(4):217-25. PMID:16213224

Retinoid x receptor heterodimers in the metabolic syndrome. Shulman AI, Mangelsdorf DJ.
N Engl J Med. 2005 Aug 11;353(6):604-15. Review. No abstract available.  PMID:16093469

Pregnane X receptor: predicting and preventing drug interactions. Kliewer SA. Thromb Res. 2005;117(1-2):133-6; discussion 145-51. Epub 2005 Aug 8. Review. No abstract available.  PMID:16087223

Weaving betaKlotho into bile acid metabolism. Moschetta A, Kliewer SA. J Clin Invest. 2005 Aug;115(8):2075-7. PMID:16075052

Structural and biochemical basis for selective repression of the orphan nuclear receptor liver receptor homolog 1 by small heterodimer partner. Li Y, Choi M, Suino K, Kovach A, Daugherty J, Kliewer SA, Xu HE. Proc Natl Acad Sci U S A. 2005 Jul 5;102(27):9505-10. Epub 2005 Jun 23. PMID:15976031

Orphan nuclear receptor LRH-1 is required to maintain Oct4 expression at the epiblast stage of embryonic development. Gu P, Goodwin B, Chung AC, Xu X, Wheeler DA, Price RR, Galardi C, Peng L, Latour AM, Koller BH, Gossen J, Kliewer SA, Cooney AJ. Mol Cell Biol. 2005 May;25(9):3492-505. PMID:1583145

LXRs regulate the balance between fat storage and oxidation. Kalaany NY, Gauthier KC, Zavacki AM, Mammen PP, Kitazume T, Peterson JA, Horton JD, Garry DJ, Bianco AC, Mangelsdorf DJ. Cell Metab. 2005 Apr;1(4):231-44. PMID:16054068

A role for the apoptosis inhibitory factor AIM/Spalpha/Api6 in atherosclerosis development.
Arai S, Shelton JM, Chen M, Bradley MN, Castrillo A, Bookout AL, Mak PA, Edwards PA, Mangelsdorf DJ, Tontonoz P, Miyazaki T. Cell Metab. 2005 Mar;1(3):201-13. PMID:16054063

A Nuclear Receptor Atlas: macrophage activation. Barish GD, Downes M, Alaynick WA, Yu RT, Ocampo CB, Bookout AL, Mangelsdorf DJ, Evans RM. Mol Endocrinol. 2005 Oct;19(10):2466-77. Epub 2005 Jul 28. PMID:16051664

A Nuclear Receptor Atlas: 3T3-L1 adipogenesis. Fu M, Sun T, Bookout AL, Downes M, Yu RT, Evans RM, Mangelsdorf DJ. Mol Endocrinol. 2005 Oct;19(10):2437-50. Epub 2005 Jul 28. PMID:16051663

Placental expression of the nuclear receptors for oxysterols LXRalpha and LXRbeta during mouse and human development. Marceau G, Volle DH, Gallot D, Mangelsdorf DJ, Sapin V, Lobaccaro JM. Anat Rec A Discov Mol Cell Evol Biol. 2005 Mar;283(1):175-81. PMID:15674823

Expression of ABCG5 and ABCG8 is required for regulation of biliary cholesterol secretion.
Yu L, Gupta S, Xu F, Liverman AD, Moschetta A, Mangelsdorf DJ, Repa JJ, Hobbs HH, Cohen JC. J Biol Chem. 2005 Mar 11;280(10):8742-7. Epub 2004 Dec 16. PMID:15611112

Crystallographic identification and functional characterization of phospholipids as ligands for the orphan nuclear receptor steroidogenic factor-1. Li Y, Choi M, Cavey G, Daugherty J, Suino K, Kovach A, Bingham NC, Kliewer SA, Xu HE. Mol Cell. 2005 Feb 18;17(4):491-502. PMID:15721253

Cholesterol detoxification by the nuclear pregnane X receptor. Kliewer SA. Proc Natl Acad Sci U S A. 2005 Feb 22;102(8):2675-6. Epub 2005 Feb 14. No abstract available.  PMID:15710871

Structural disorder in the complex of human pregnane X receptor and the macrolide antibiotic rifampicin. Chrencik JE, Orans J, Moore LB, Xue Y, Peng L, Collins JL, Wisely GB, Lambert MH, Kliewer SA, Redinbo MR. Mol Endocrinol. 2005 May;19(5):1125-34. Epub 2005 Feb 10. PMID:15705662

The nuclear xenobiotic receptor CAR: structural determinants of constitutive activation and heterodimerization. Suino K, Peng L, Reynolds R, Li Y, Cha JY, Repa JJ, Kliewer SA, Xu HE.
Mol Cell. 2004 Dec 22;16(6):893-905. PMID:15610733

Enhanced acetaminophen toxicity by activation of the pregnane X receptor. Guo GL, Moffit JS, Nicol CJ, Ward JM, Aleksunes LA, Slitt AL, Kliewer SA, Manautou JE, Gonzalez FJ. Toxicol Sci. 2004 Dec;82(2):374-80. Epub 2004 Sep 29. PMID:15456926

Prevention of cholesterol gallstone disease by FXR agonists in a mouse model. Moschetta A, Bookout AL, Mangelsdorf DJ. Nat Med. 2004 Dec;10(12):1352-8. Epub 2004 Nov 21. PMID:15558057

Nuclear oxysterol receptors, LXRs, are involved in the maintenance of mouse caput epididymidis structure and functions. Frenoux JM, Vernet P, Volle DH, Britan A, Saez F, Kocer A, Henry-Berger J, Mangelsdorf DJ, Lobaccaro JM, Drevet JR. J Mol Endocrinol. 2004 Oct;33(2):361-75. PMID:15525595

Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c.
Watanabe M, Houten SM, Wang L, Moschetta A, Mangelsdorf DJ, Heyman RA, Moore DD, Auwerx J. J Clin Invest. 2004 May;113(10):1408-18. PMID:15146238

Genetic evidence that the human CYP2R1 enzyme is a key vitamin D 25-hydroxylase.
Cheng JB, Levine MA, Bell NH, Mangelsdorf DJ, Russell DW. Proc Natl Acad Sci U S A. 2004 May 18;101(20):7711-5. Epub 2004 May 5. PMID:15128933

Genetic evidence that the human CYP2R1 enzyme is a key vitamin D 25-hydroxylase.
Cheng JB, Levine MA, Bell NH, Mangelsdorf DJ, Russell DW. Proc Natl Acad Sci U S A. 2004 May 18;101(20):7711-5. Epub 2004 May 5. PMID:15128933

Cell-free ligand binding assays for nuclear receptors. Jones SA, Parks DJ, Kliewer SA.
Methods Enzymol. 2003;364:53-71. PMID:14631839

LuXuRies of lipid homeostasis: the unity of nuclear hormone receptors, transcription regulation, and cholesterol sensing. Zhang Y, Mangelsdorf DJ. Mol Interv. 2002 Apr;2(2):78-87. Review. PMID:14993353

Regulation of the aldo-keto reductase gene akr1b7 by the nuclear oxysterol receptor LXRalpha (liver X receptor-alpha) in the mouse intestine: putative role of LXRs in lipid detoxification processes. Volle DH, Repa JJ, Mazur A, Cummins CL, Val P, Henry-Berger J, Caira F, Veyssiere G, Mangelsdorf DJ, Lobaccaro JM. Mol Endocrinol. 2004 Apr;18(4):888-98. Epub 2004 Jan 22. PMID:14739254

Identification of a liver-specific uridine phosphorylase that is regulated by multiple lipid-sensing nuclear receptors. Zhang Y, Repa JJ, Inoue Y, Hayhurst GP, Gonzalez FJ, Mangelsdorf DJ.
Mol Endocrinol. 2004 Apr;18(4):851-62. Epub 2004 Jan 8. PMID:14715930

Hepatoprotection by the farnesoid X receptor agonist GW4064 in rat models of intra- and extrahepatic cholestasis. Liu Y, Binz J, Numerick MJ, Dennis S, Luo G, Desai B, MacKenzie KI, Mansfield TA, Kliewer SA, Goodwin B, Jones SA. J Clin Invest. 2003 Dec;112(11):1678-87. Epub 2003 Nov 17. PMID:14623915

Anthrax mounts a nuclear attack on glucocorticoid signaling. Kliewer SA. Trends Pharmacol Sci. 2003 Nov;24(11):558-9. Review. PMID:14607073

Structural determinants for vitamin D receptor response to endocrine and xenobiotic signals.
Adachi R, Shulman AI, Yamamoto K, Shimomura I, Yamada S, Mangelsdorf DJ, Makishima M.
Mol Endocrinol. 2004 Jan;18(1):43-52. Epub 2003 Oct 2. PMID:14525957

Expression of LRH-1 and SF-1 in the mouse ovary: localization in different cell types correlates with differing function. Hinshelwood MM, Repa JJ, Shelton JM, Richardson JA, Mangelsdorf DJ, Mendelson CR. Mol Cell Endocrinol. 2003 Sep 30;207(1-2):39-45. PMID:12972182

The role of liver X receptor-alpha in the fatty acid regulation of hepatic gene expression.
Pawar A, Botolin D, Mangelsdorf DJ, Jump DB. J Biol Chem. 2003 Oct 17;278(42):40736-43. Epub 2003 Aug 13. PMID:12917410

Complementary roles of farnesoid X receptor, pregnane X receptor, and constitutive androstane receptor in protection against bile acid toxicity. Guo GL, Lambert G, Negishi M, Ward JM, Brewer HB Jr, Kliewer SA, Gonzalez FJ, Sinal CJ. J Biol Chem. 2003 Nov 14;278(46):45062-71. Epub 2003 Aug 15. PMID:12923173

The nuclear pregnane X receptor regulates xenobiotic detoxification. Kliewer SA. J Nutr. 2003 Jul;133(7 Suppl):2444S-2447S. Review. PMID:12840222

Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis. Holt JA, Luo G, Billin AN, Bisi J, McNeill YY, Kozarsky KF, Donahee M, Wang DY, Mansfield TA, Kliewer SA, Goodwin B, Jones SA. Genes Dev. 2003 Jul 1;17(13):1581-91. Epub 2003 Jun 18. PMID:12815072

Establishment of a monoclonal antibody for human LXRalpha: Detection of LXRalpha protein expression in human macrophages. Watanabe Y, Tanaka T, Uchiyama Y, Takeno T, Izumi A, Yamashita H, Kumakura J, Iwanari H, Shu-Ying J, Naito M, Mangelsdorf DJ, Hamakubo T, Kodama T. Nucl Recept. 2003 May 9;1(1):1. PMID:12904258

De-orphanization of cytochrome P450 2R1: a microsomal vitamin D 25-hydroxilase.
Cheng JB, Motola DL, Mangelsdorf DJ, Russell DW. J Biol Chem. 2003 Sep 26;278(39):38084-93. Epub 2003 Jul 16. PMID:12867411

The Drosophila orphan nuclear receptor DHR38 mediates an atypical ecdysteroid signaling pathway. Baker KD, Shewchuk LM, Kozlova T, Makishima M, Hassell A, Wisely B, Caravella JA, Lambert MH, Reinking JL, Krause H, Thummel CS, Willson TM, Mangelsdorf DJ.
Cell. 2003 Jun 13;113(6):731-42. PMID:12809604

Activation of liver X receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue. Laffitte BA, Chao LC, Li J, Walczak R, Hummasti S, Joseph SB, Castrillo A, Wilpitz DC, Mangelsdorf DJ, Collins JL, Saez E, Tontonoz P. Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5419-24. Epub 2003 Apr 15. PMID:12697904

Liver X receptor signaling pathways in cardiovascular disease. Tontonoz P, Mangelsdorf DJ.
Mol Endocrinol. 2003 Jun;17(6):985-93. Epub 2003 Apr 10. Review. PMID:12690094

Interaction between vitamin D receptor and vitamin D ligands: two-dimensional alanine scanning mutational analysis. Choi M, Yamamoto K, Itoh T, Makishima M, Mangelsdorf DJ, Moras D, DeLuca HF, Yamada S. Chem Biol. 2003 Mar;10(3):261-70. PMID:12670540

Liver X receptor activators display anti-inflammatory activity in irritant and allergic contact dermatitis models: liver-X-receptor-specific inhibition of inflammation and primary cytokine production. Fowler AJ, Sheu MY, Schmuth M, Kao J, Fluhr JW, Rhein L, Collins JL, Willson TM, Mangelsdorf DJ, Elias PM, Feingold KR. J Invest Dermatol. 2003 Feb;120(2):246-55. PMID:12542530

Liver X receptor-dependent repression of matrix metalloproteinase-9 expression in macrophages. Castrillo A, Joseph SB, Marathe C, Mangelsdorf DJ, Tontonoz P. J Biol Chem. 2003 Mar 21;278(12):10443-9. Epub 2003 Jan 16. PMID:12531895

Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes. Maglich JM, Parks DJ, Moore LB, Collins JL, Goodwin B, Billin AN, Stoltz CA, Kliewer SA, Lambert MH, Willson TM, Moore JT. J Biol Chem. 2003 May 9;278(19):17277-83. Epub 2003 Feb 27. PMID:12611900

2.1 A crystal structure of human PXR in complex with the St. John's wort compound hyperforin.

Watkins RE, Maglich JM, Moore LB, Wisely GB, Noble SM, Davis-Searles PR, Lambert MH, Kliewer SA, Redinbo MR. Biochemistry. 2003 Feb 18;42(6):1430-8. PMID:12578355

Functional and structural comparison of PXR and CAR. Moore JT, Moore LB, Maglich JM, Kliewer SA. Biochim Biophys Acta. 2003 Feb 17;1619(3):235-8. Review. PMID:12573482

Reciprocal regulation of inflammation and lipid metabolism by liver X receptors. Joseph SB, Castrillo A, Laffitte BA, Mangelsdorf DJ, Tontonoz P. Nat Med. 2003 Feb;9(2):213-9. Epub 2003 Jan 13. PMID:12524534

Differential regulation of rat and human CYP7A1 by the nuclear oxysterol receptor liver X receptor-alpha. Goodwin B, Watson MA, Kim H, Miao J, Kemper JK, Kliewer SA. Mol Endocrinol. 2003 Mar;17(3):386-94. Epub 2002 Dec 12. PMID:12554795

Identification of bile acid precursors as endogenous ligands for the nuclear xenobiotic pregnane X receptor. Goodwin B, Gauthier KC, Umetani M, Watson MA, Lochansky MI, Collins JL, Leitersdorf E, Mangelsdorf DJ, Kliewer SA, Repa JJ. Proc Natl Acad Sci U S A. 2003 Jan 7;100(1):223-8. Epub 2002 Dec 30. PMID:12509506

The liver X receptor gene team: potential new players in atherosclerosis. Repa JJ, Mangelsdorf DJ. Nat Med. 2002 Nov;8(11):1243-8. Review. No abstract available.  PMID:12411951

The generation of monoclonal antibodies against human peroxisome proliferator-activated receptors (PPARs). Tanaka T, Takeno T, Watanabe Y, Uchiyama Y, Murakami T, Yamashita H, Suzuki A, Aoi R, Iwanari H, Jiang SY, Naito M, Tachibana K, Doi T, Shulman AI, Mangelsdorf DJ, Reiter R, Auwerx J, Hamakubo T, Kodama T. J Atheroscler Thromb. 2002;9(5):233-42. PMID:12409633

Nuclear receptor regulation of genes involved in bile acid metabolism. Moore JT, Goodwin B, Willson TM, Kliewer SA. Crit Rev Eukaryot Gene Expr. 2002;12(2):119-35. Review. PMID:12434926

Use of in vitro pregnane X receptor assays to assess CYP3A4 induction potential of drug candidates. Jones SA, Moore LB, Wisely GB, Kliewer SA. Methods Enzymol. 2002;357:161-70. No abstract available.  PMID:12424907

The nuclear pregnane X receptor: a key regulator of xenobiotic metabolism. Kliewer SA, Goodwin B, Willson TM. Endocr Rev. 2002 Oct;23(5):687-702. Review. PMID:12372848

Nuclear pregnane x receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification. Maglich JM, Stoltz CM, Goodwin B, Hawkins-Brown D, Moore JT, Kliewer SA. Mol Pharmacol. 2002 Sep;62(3):638-46. PMID:12181440

PPAR alpha is necessary for the lipopenic action of hyperleptinemia on white adipose and liver tissue. Lee Y, Yu X, Gonzales F, Mangelsdorf DJ, Wang MY, Richardson C, Witters LA, Unger RH. Proc Natl Acad Sci U S A. 2002 Sep 3;99(18):11848-53. Epub 2002 Aug 23. PMID:12195019

Identification of macrophage liver X receptors as inhibitors of atherosclerosis. Tangirala RK, Bischoff ED, Joseph SB, Wagner BL, Walczak R, Laffitte BA, Daige CL, Thomas D, Heyman RA, Mangelsdorf DJ, Wang X, Lusis AJ, Tontonoz P, Schulman IG. Proc Natl Acad Sci U S A. 2002 Sep 3;99(18):11896-901. Epub 2002 Aug 22. PMID:12193651

Fatty acid regulation of liver X receptors (LXR) and peroxisome proliferator-activated receptor alpha (PPARalpha ) in HEK293 cells. Pawar A, Xu J, Jerks E, Mangelsdorf DJ, Jump DB.
J Biol Chem. 2002 Oct 18;277(42):39243-50. Epub 2002 Aug 2. PMID:12161442

Human organic anion transporting polypeptide 8 promoter is transactivated by the farnesoid X receptor/bile acid receptor. Jung D, Podvinec M, Meyer UA, Mangelsdorf DJ, Fried M, Meier PJ, Kullak-Ublick GA. Gastroenterology. 2002 Jun;122(7):1954-66. PMID:12055601

Regulated expression of the apolipoprotein E/C-I/C-IV/C-II gene cluster in murine and human macrophages. A critical role for nuclear liver X receptors alpha and beta. Mak PA, Laffitte BA, Desrumaux C, Joseph SB, Curtiss LK, Mangelsdorf DJ, Tontonoz P, Edwards PA. J Biol Chem. 2002 Aug 30;277(35):31900-8. Epub 2002 May 24. PMID:12032151

Vitamin D receptor as an intestinal bile acid sensor. Makishima M, Lu TT, Xie W, Whitfield GK, Domoto H, Evans RM, Haussler MR, Mangelsdorf DJ. Science. 2002 May 17;296(5571):1313-6. PMID:12016314

A natural product that lowers cholesterol as an antagonist ligand for FXR. Urizar NL, Liverman AB, Dodds DT, Silva FV, Ordentlich P, Yan Y, Gonzalez FJ, Heyman RA, Mangelsdorf DJ, Moore DD. Science. 2002 May 31;296(5573):1703-6. Epub 2002 May 2. PMID:11988537

PXR, CAR and drug metabolism. Willson TM, Kliewer SA. Nat Rev Drug Discov. 2002 Apr;1(4):259-66. Review. PMID:12120277

Regulation of cholesterol homeostasis by the liver X receptors in the central nervous system.
Whitney KD, Watson MA, Collins JL, Benson WG, Stone TM, Numerick MJ, Tippin TK, Wilson JG, Winegar DA, Kliewer SA. Mol Endocrinol. 2002 Jun;16(6):1378-85. PMID:12040022

Nuclear receptors. I. Nuclear receptors and bile acid homeostasis. Goodwin B, Kliewer SA.
Am J Physiol Gastrointest Liver Physiol. 2002 Jun;282(6):G926-31. Review. PMID:12016116

Identification of a nonsteroidal liver X receptor agonist through parallel array synthesis of tertiary amines. Collins JL, Fivush AM, Watson MA, Galardi CM, Lewis MC, Moore LB, Parks DJ, Wilson JG, Tippin TK, Binz JG, Plunket KD, Morgan DG, Beaudet EJ, Whitney KD, Kliewer SA, Willson TM. J Med Chem. 2002 May 9;45(10):1963-6. PMID:11985463

Pregnane X receptor (PXR), constitutive androstane receptor (CAR), and benzoate X receptor (BXR) define three pharmacologically distinct classes of nuclear receptors. Moore LB, Maglich JM, McKee DD, Wisely B, Willson TM, Kliewer SA, Lambert MH, Moore JT. Mol Endocrinol. 2002 May;16(5):977-86. PMID:11981033

Peroxisome proliferator-activated receptor-alpha regulates fatty acid utilization in primary human skeletal muscle cells. Muoio DM, Way JM, Tanner CJ, Winegar DA, Kliewer SA, Houmard JA, Kraus WE, Dohm GL. Diabetes. 2002 Apr;51(4):901-9. PMID:11916905

Regulation of xenobiotic and bile acid metabolism by the nuclear pregnane X receptor.
Kliewer SA, Willson TM. J Lipid Res. 2002 Mar;43(3):359-64. Review. PMID:11893771

Regulation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 by the liver X receptors alpha and beta. Repa JJ, Berge KE, Pomajzl C, Richardson JA, Hobbs H, Mangelsdorf DJ. J Biol Chem. 2002 May 24;277(21):18793-800. Epub 2002 Mar 18. PMID:11901146

Structural basis for antagonist-mediated recruitment of nuclear co-repressors by PPARalpha.
Xu HE, Stanley TB, Montana VG, Lambert MH, Shearer BG, Cobb JE, McKee DD, Galardi CM, Plunket KD, Nolte RT, Parks DJ, Moore JT, Kliewer SA, Willson TM, Stimmel JB. Nature. 2002 Feb 14;415(6873):813-7. PMID:11845213

Oxysterol stimulation of epidermal differentiation is mediated by liver X receptor-beta in murine epidermis. Kömüves LG, Schmuth M, Fowler AJ, Elias PM, Hanley K, Man MQ, Moser AH, Lobaccaro JM, Williams ML, Mangelsdorf DJ, Feingold KR. J Invest Dermatol. 2002 Jan;118(1):25-34. PMID:11851872

Regulation of cyp3a gene transcription by the pregnane x receptor. Goodwin B, Redinbo MR, Kliewer SA. Annu Rev Pharmacol Toxicol. 2002;42:1-23. Review. PMID:11807162

Structural determinants of ligand binding selectivity between the peroxisome proliferator-activated receptors. Xu HE, Lambert MH, Montana VG, Plunket KD, Moore LB, Collins JL, Oplinger JA, Kliewer SA, Gampe RT Jr, McKee DD, Moore JT, Willson TM. Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):13919-24. Epub 2001 Nov 6. PMID:11698662

Chemical genomics: functional analysis of orphan nuclear receptors in the regulation of bile acid metabolism. Willson TM, Jones SA, Moore JT, Kliewer SA. Med Res Rev. 2001 Nov;21(6):513-22. Review. PMID:11607932

Nuclear receptors and lipid physiology: opening the X-files. Chawla A, Repa JJ, Evans RM, Mangelsdorf DJ. Science. 2001 Nov 30;294(5548):1866-70. Review. PMID:11729302

Nuclear receptors and lipid physiology: opening the X-files. Chawla A, Repa JJ, Evans RM, Mangelsdorf DJ. Science. 2001 Nov 30;294(5548):1866-70. Review. PMID:11729302

Regulation of lipoprotein lipase by the oxysterol receptors, LXRalpha and LXRbeta. Zhang Y, Repa JJ, Gauthier K, Mangelsdorf DJ. J Biol Chem. 2001 Nov 16;276(46):43018-24. Epub 2001 Sep 18. PMID:11562371

Effects of fenofibrate on lipid parameters in obese rhesus monkeys. Winegar DA, Brown PJ, Wilkison WO, Lewis MC, Ott RJ, Tong WQ, Brown HR, Lehmann JM, Kliewer SA, Plunket KD, Way JM, Bodkin NL, Hansen BC. J Lipid Res. 2001 Oct;42(10):1543-51. PMID:11590209

Prospects for prevention and treatment of cancer with selective PPARgamma modulators (SPARMs). Sporn MB, Suh N, Mangelsdorf DJ. Trends Mol Med. 2001 Sep;7(9):395-400. Review. PMID:11530334

Liver X receptor (LXR) regulation of the LXRalpha gene in human macrophages. Whitney KD, Watson MA, Goodwin B, Galardi CM, Maglich JM, Wilson JG, Willson TM, Collins JL, Kliewer SA. J Biol Chem. 2001 Nov 23;276(47):43509-15. Epub 2001 Aug 23. PMID:11546778

Regulation of the human CYP2B6 gene by the nuclear pregnane X receptor. Goodwin B, Moore LB, Stoltz CM, McKee DD, Kliewer SA. Mol Pharmacol. 2001 Sep;60(3):427-31. PMID:11502872

Orphan nuclear receptors as eLiXiRs and FiXeRs of sterol metabolism. Lu TT, Repa JJ, Mangelsdorf DJ. J Biol Chem. 2001 Oct 12;276(41):37735-8. Epub 2001 Jul 17. Review. No abstract available.  PMID:11459853
128.

[Regulation of lipid metabolism by the orphan nuclear receptors]. Lobaccaro JM, Repa JJ, Lu TT, Caira F, Henry-Berger J, Volle DH, Mangelsdorf DJ. Ann Endocrinol (Paris). 2001 Jun;62(3):239-47. Review. French.  PMID:11458177

The orphan nuclear receptor, shp, mediates bile acid-induced inhibition of the rat bile acid transporter, ntcp. Denson LA, Sturm E, Echevarria W, Zimmerman TL, Makishima M, Mangelsdorf DJ, Karpen SJ. Gastroenterology. 2001 Jul;121(1):140-7. PMID:11438503

The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity.
Watkins RE, Wisely GB, Moore LB, Collins JL, Lambert MH, Williams SP, Willson TM, Kliewer SA, Redinbo MR. Science. 2001 Jun 22;292(5525):2329-33. Epub 2001 Jun 14. PMID:11408620

Peroxisome proliferator-activated receptor gamma and metabolic disease. Willson TM, Lambert MH, Kliewer SA. Annu Rev Biochem. 2001;70:341-67. Review. PMID:11395411

Human bile salt export pump promoter is transactivated by the farnesoid X receptor/bile acid receptor. Ananthanarayanan M, Balasubramanian N, Makishima M, Mangelsdorf DJ, Suchy FJ. J Biol Chem. 2001 Aug 3;276(31):28857-65. Epub 2001 May 31. PMID:11387316

Adipose tissue resistin expression is severely suppressed in obesity and stimulated by peroxisome proliferator-activated receptor gamma agonists. Way JM, Görgün CZ, Tong Q, Uysal KT, Brown KK, Harrington WW, Oliver WR Jr, Willson TM, Kliewer SA, Hotamisligil GS.
J Biol Chem. 2001 Jul 13;276(28):25651-3. Epub 2001 May 23. PMID:11373275

A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport. Oliver WR Jr, Shenk JL, Snaith MR, Russell CS, Plunket KD, Bodkin NL, Lewis MC, Winegar DA, Sznaidman ML, Lambert MH, Xu HE, Sternbach DD, Kliewer SA, Hansen BC, Willson TM. Proc Natl Acad Sci U S A. 2001 Apr 24;98(9):5306-11. Epub 2001 Apr 17. PMID:11309497

The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity.
Staudinger JL, Goodwin B, Jones SA, Hawkins-Brown D, MacKenzie KI, LaTour A, Liu Y, Klaassen CD, Brown KK, Reinhard J, Willson TM, Koller BH, Kliewer SA. Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3369-74. PMID:11248085

Peroxisome proliferator-activated receptors: from genes to physiology. Kliewer SA, Xu HE, Lambert MH, Willson TM. Recent Prog Horm Res. 2001;56:239-63. Review. PMID:11237216

Comprehensive messenger ribonucleic acid profiling reveals that peroxisome proliferator-activated receptor gamma activation has coordinate effects on gene expression in multiple insulin-sensitive tissues. Way JM, Harrington WW, Brown KK, Gottschalk WK, Sundseth SS, Mansfield TA, Ramachandran RK, Willson TM, Kliewer SA. Endocrinology. 2001 Mar;142(3):1269-77. PMID:11181544

Reduction of atherosclerosis in apolipoprotein E knockout mice by activation of the retinoid X receptor. Claudel T, Leibowitz MD, Fiévet C, Tailleux A, Wagner B, Repa JJ, Torpier G, Lobaccaro JM, Paterniti JR, Mangelsdorf DJ, Heyman RA, Auwerx J. Proc Natl Acad Sci U S A. 2001 Feb 27;98(5):2610-5. Epub 2001 Feb 20. PMID:11226287

Reduction of atherosclerosis in apolipoprotein E knockout mice by activation of the retinoid X receptor. Claudel T, Leibowitz MD, Fiévet C, Tailleux A, Wagner B, Repa JJ, Torpier G, Lobaccaro JM, Paterniti JR, Mangelsdorf DJ, Heyman RA, Auwerx J. Proc Natl Acad Sci U S A. 2001 Feb 27;98(5):2610-5. Epub 2001 Feb 20. PMID:11226287

Use of the nuclear receptor PXR to predict drug interactions. Moore JT, Kliewer SA.
Toxicology. 2000 Nov 16;153(1-3):1-10. Review. PMID:11090943

Role of LXRs in control of lipogenesis. Schultz JR, Tu H, Luk A, Repa JJ, Medina JC, Li L, Schwendner S, Wang S, Thoolen M, Mangelsdorf DJ, Lustig KD, Shan B. Genes Dev. 2000 Nov 15;14(22):2831-8. PMID:11090131

Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta. Repa JJ, Liang G, Ou J, Bashmakov Y, Lobaccaro JM, Shimomura I, Shan B, Brown MS, Goldstein JL, Mangelsdorf DJ. Genes Dev. 2000 Nov 15;14(22):2819-30. PMID:1090130

A synthetic triterpenoid, 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO), is a ligand for the peroxisome proliferator-activated receptor gamma. Wang Y, Porter WW, Suh N, Honda T, Gribble GW, Leesnitzer LM, Plunket KD, Mangelsdorf DJ, Blanchard SG, Willson TM, Sporn MB. Mol Endocrinol. 2000 Oct;14(10):1550-6. PMID:11043571

The role of orphan nuclear receptors in the regulation of cholesterol homeostasis. Repa JJ, Mangelsdorf DJ. Annu Rev Cell Dev Biol. 2000;16:459-81. Review. PMID:11031244

Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors. Lu TT, Makishima M, Repa JJ, Schoonjans K, Kerr TA, Auwerx J, Mangelsdorf DJ. Mol Cell. 2000 Sep;6(3):507-15. PMID:11030331

Transcriptional activation of the Drosophila ecdysone receptor by insect and plant ecdysteroids.
Baker KD, Warren JT, Thummel CS, Gilbert LI, Mangelsdorf DJ. Insect Biochem Mol Biol. 2000 Nov;30(11):1037-43. PMID:10989290

Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers.
Repa JJ, Turley SD, Lobaccaro JA, Medina J, Li L, Lustig K, Shan B, Heyman RA, Dietschy JM, Mangelsdorf DJ. Science. 2000 Sep 1;289(5484):1524-9. PMID:10968783

Stress pathway activation induces phosphorylation of retinoid X receptor. Lee HY, Suh YA, Robinson MJ, Clifford JL, Hong WK, Woodgett JR, Cobb MH, Mangelsdorf DJ, Kurie JM. J Biol Chem. 2000 Oct 13;275(41):32193-9. PMID:10938283

A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis. Goodwin B, Jones SA, Price RR, Watson MA, McKee DD, Moore LB, Galardi C, Wilson JG, Lewis MC, Roth ME, Maloney PR, Willson TM, Kliewer SA. Mol Cell. 2000 Sep;6(3):517-26. PMID:11030332

Hepatocyte-specific mutation establishes retinoid X receptor alpha as a heterodimeric integrator of multiple physiological processes in the liver. Wan YJ, An D, Cai Y, Repa JJ, Hung-Po Chen T, Flores M, Postic C, Magnuson MA, Chen J, Chien KR, French S, Mangelsdorf DJ, Sucov HM. Mol Cell Biol. 2000 Jun;20(12):4436-44. PMID:10825207

Asymmetry in the PPARgamma/RXRalpha crystal structure reveals the molecular basis of heterodimerization among nuclear receptors. Gampe RT Jr, Montana VG, Lambert MH, Miller AB, Bledsoe RK, Milburn MV, Kliewer SA, Willson TM, Xu HE. Mol Cell. 2000 Mar;5(3):545-55. PMID:10882139

St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor.
Moore LB, Goodwin B, Jones SA, Wisely GB, Serabjit-Singh CJ, Willson TM, Collins JL, Kliewer SA. Proc Natl Acad Sci U S A. 2000 Jun 20;97(13):7500-2. PMID:10852961

Human white/murine ABC8 mRNA levels are highly induced in lipid-loaded macrophages. A transcriptional role for specific oxysterols. Venkateswaran A, Repa JJ, Lobaccaro JM, Bronson A, Mangelsdorf DJ, Edwards PA. J Biol Chem. 2000 May 12;275(19):14700-7. PMID:10799558

Alteration of a single amino acid in peroxisome proliferator-activated receptor-alpha (PPAR alpha) generates a PPAR delta phenotype. Takada I, Yu RT, Xu HE, Lambert MH, Montana VG, Kliewer SA, Evans RM, Umesono K. Mol Endocrinol. 2000 May;14(5):733-40. PMID:10809235

Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands. Moore LB, Parks DJ, Jones SA, Bledsoe RK, Consler TG, Stimmel JB, Goodwin B, Liddle C, Blanchard SG, Willson TM, Collins JL, Kliewer SA. J Biol Chem. 2000 May 19;275(20):15122-7. PMID:10748001

Interleukin-1beta suppresses retinoid transactivation of two hepatic transporter genes involved in bile formation. Denson LA, Auld KL, Schiek DS, McClure MH, Mangelsdorf DJ, Karpen SJ. J Biol Chem. 2000 Mar 24;275(12):8835-43. PMID:10722729

Oxysterols induce differentiation in human keratinocytes and increase Ap-1-dependent involucrin transcription. Hanley K, Ng DC, He SS, Lau P, Min K, Elias PM, Bikle DD, Mangelsdorf DJ, Williams ML, Feingold KR. J Invest Dermatol. 2000 Mar;114(3):545-53. PMID:10692116

Modifying ligand specificity of gene regulatory proteins. Doyle DF, Mangelsdorf DJ, Corey DR. Curr Opin Chem Biol. 2000 Feb;4(1):60-3. Review. PMID:10679376

The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution.
Jones SA, Moore LB, Shenk JL, Wisely GB, Hamilton GA, McKee DD, Tomkinson NC, LeCluyse EL, Lambert MH, Willson TM, Kliewer SA, Moore JT. Mol Endocrinol. 2000 Jan;14(1):27-39. PMID:10628745

Nuclear receptor regulation of cholesterol and bile acid metabolism. Repa JJ, Mangelsdorf DJ. Curr Opin Biotechnol. 1999 Dec;10(6):557-63. Review. PMID:10600692

The PPARs and PXRs: nuclear xenobiotic receptors that define novel hormone signaling pathways. Kliewer SA, Lehmann JM, Milburn MV, Willson TM. Recent Prog Horm Res. 1999;54:345-67; discussion 367-8. Review. PMID:10548883

Identification of a bile acid-responsive element in the human ileal bile acid-binding protein gene. Involvement of the farnesoid X receptor/9-cis-retinoic acid receptor heterodimer. Grober J, Zaghini I, Fujii H, Jones SA, Kliewer SA, Willson TM, Ono T, Besnard P. J Biol Chem. 1999 Oct 15;274(42):29749-54. PMID:10514450

A ureido-thioisobutyric acid (GW9578) is a subtype-selective PPARalpha agonist with potent lipid-lowering activity. Brown PJ, Winegar DA, Plunket KD, Moore LB, Lewis MC, Wilson JG, Sundseth SS, Koble CS, Wu Z, Chapman JM, Lehmann JM, Kliewer SA, Willson TM. J Med Chem. 1999 Sep 23;42(19):3785-8. No abstract available.  PMID:10508427

A novel N-aryl tyrosine activator of peroxisome proliferator-activated receptor-gamma reverses the diabetic phenotype of the Zucker diabetic fatty rat. Brown KK, Henke BR, Blanchard SG, Cobb JE, Mook R, Kaldor I, Kliewer SA, Lehmann JM, Lenhard JM, Harrington WW, Novak PJ, Faison W, Binz JG, Hashim MA, Oliver WO, Brown HR, Parks DJ, Plunket KD, Tong WQ, Menius JA, Adkison K, Noble SA, Willson TM. Diabetes. 1999 Jul;48(7):1415-24. PMID:10389847

A peroxisome proliferator-activated receptor gamma ligand inhibits adipocyte differentiation.
Oberfield JL, Collins JL, Holmes CP, Goreham DM, Cooper JP, Cobb JE, Lenhard JM, Hull-Ryde EA, Mohr CP, Blanchard SG, Parks DJ, Moore LB, Lehmann JM, Plunket K, Miller AB, Milburn MV, Kliewer SA, Willson TM. Proc Natl Acad Sci U S A. 1999 May 25;96(11):6102-6. PMID:10339548

Identification of a nuclear receptor for bile acids. Makishima M, Okamoto AY, Repa JJ, Tu H, Learned RM, Luk A, Hull MV, Lustig KD, Mangelsdorf DJ, Shan B. Science. 1999 May 21;284(5418):1362-5. PMID:10334992

Bile acids: natural ligands for an orphan nuclear receptor. Parks DJ, Blanchard SG, Bledsoe RK, Chandra G, Consler TG, Kliewer SA, Stimmel JB, Willson TM, Zavacki AM, Moore DD, Lehmann JM. Science. 1999 May 21;284(5418):1365-8. PMID:10334993

Orphan nuclear receptors: shifting endocrinology into reverse. Kliewer SA, Lehmann JM, Willson TM. Science. 1999 Apr 30;284(5415):757-60. Review. PMID:10221899

All-trans-retinoic acid inhibits Jun N-terminal kinase by increasing dual-specificity phosphatase activity. Lee HY, Sueoka N, Hong WK, Mangelsdorf DJ, Claret FX, Kurie JM. Mol Cell Biol. 1999 Mar;19(3):1973-80. PMID:10022884

Molecular recognition of fatty acids by peroxisome proliferator-activated receptors.
Xu HE, Lambert MH, Montana VG, Parks DJ, Blanchard SG, Brown PJ, Sternbach DD, Lehmann JM, Wisely GB, Willson TM, Kliewer SA, Milburn MV. Mol Cell. 1999 Mar;3(3):397-403. PMID:10198642

A novel synthetic oleanane triterpenoid, 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid, with potent differentiating, antiproliferative, and anti-inflammatory activity. Suh N, Wang Y, Honda T, Gribble GW, Dmitrovsky E, Hickey WF, Maue RA, Place AE, Porter DM, Spinella MJ, Williams CR, Wu G, Dannenberg AJ, Flanders KC, Letterio JJ, Mangelsdorf DJ, Nathan CF, Nguyen L, Porter WW, Ren RF, Roberts AB, Roche NS, Subbaramaiah K, Sporn MB. Cancer Res. 1999 Jan 15;59(2):336-41. PMID:9927043

Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbeta.
Janowski BA, Grogan MJ, Jones SA, Wisely GB, Kliewer SA, Corey EJ, Mangelsdorf DJ. Proc Natl Acad Sci U S A. 1999 Jan 5;96(1):266-71. PMID:9874807

N-(2-Benzoylphenyl)-L-tyrosine PPARgamma agonists. 1. Discovery of a novel series of potent antihyperglycemic and antihyperlipidemic agents. Henke BR, Blanchard SG, Brackeen MF, Brown KK, Cobb JE, Collins JL, Harrington WW Jr, Hashim MA, Hull-Ryde EA, Kaldor I, Kliewer SA, Lake DH, Leesnitzer LM, Lehmann JM, Lenhard JM, Orband-Miller LA, Miller JF, Mook RA Jr, Noble SA, Oliver W Jr, Parks DJ, Plunket KD, Szewczyk JR, Willson TM. J Med Chem. 1998 Dec 3;41(25):5020-36. PMID:9836620

The nuclear receptor PPARgamma - bigger than fat. Kliewer SA, Willson TM. Curr Opin Genet Dev. 1998 Oct;8(5):576-81. Review. PMID:9794815

The LXRs: a new class of oxysterol receptors. Peet DJ, Janowski BA, Mangelsdorf DJ. Curr Opin Genet Dev. 1998 Oct;8(5):571-5. Review. PMID:9794827

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions. Lehmann JM, McKee DD, Watson MA, Willson TM, Moore JT, Kliewer SA. J Clin Invest. 1998 Sep 1;102(5):1016-23. PMID:9727070

Cloning and characterization of human estrogen receptor beta isoforms. Moore JT, McKee DD, Slentz-Kesler K, Moore LB, Jones SA, Horne EL, Su JL, Kliewer SA, Lehmann JM, Willson TM. Biochem Biophys Res Commun. 1998 Jun 9;247(1):75-8. PMID:9636657

Isolation of two functional retinoid X receptor subtypes from the Ixodid tick, Amblyomma americanum (L.). Guo X, Xu Q, Harmon MA, Jin X, Laudet V, Mangelsdorf DJ, Palmer MJ. Mol Cell Endocrinol. 1998 Apr 30;139(1-2):45-60. PMID:9705073

Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha. Peet DJ, Turley SD, Ma W, Janowski BA, Lobaccaro JM, Hammer RE, Mangelsdorf DJ. Cell. 1998 May 29;93(5):693-704. PMID:9630215

Characterization of a region upstream of exon I.1 of the human CYP19 (aromatase) gene that mediates regulation by retinoids in human choriocarcinoma cells. Sun T, Zhao Y, Mangelsdorf DJ, Simpson ER. Endocrinology. 1998 Apr;139(4):1684-91. PMID:9528950

An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway.
Kliewer SA, Moore JT, Wade L, Staudinger JL, Watson MA, Jones SA, McKee DD, Oliver BB, Willson TM, Zetterström RH, Perlmann T, Lehmann JM. Cell. 1998 Jan 9;92(1):73-82. PMID:9489701

Identification of peroxisome proliferator-activated receptor ligands from a biased chemical library. Brown PJ, Smith-Oliver TA, Charifson PS, Tomkinson NC, Fivush AM, Sternbach DD, Wade LE, Orband-Miller L, Parks DJ, Blanchard SG, Kliewer SA, Lehmann JM, Willson TM. Chem Biol. 1997 Dec;4(12):909-18. PMID:9427656

Isolation of a functional ecdysteroid receptor homologue from the ixodid tick Amblyomma americanum (L.). Guo X, Harmon MA, Laudet V, Mangelsdorf DJ, Palmer MJ. Insect Biochem Mol Biol. 1997 Nov;27(11):945-62. PMID:9501418

Engineering novel specificities for ligand-activated transcription in the nuclear hormone receptor RXR. Peet DJ, Doyle DF, Corey DR, Mangelsdorf DJ. Chem Biol. 1998 Jan;5(1):13-21. PMID:9479476

Trypanosoma brucei: effects of methoprene and other isoprenoid compounds on procyclic and bloodstream forms in vitro and in mice. Harmon MA, Scott TC, Li Y, Boehm MF, Phillips MA, Mangelsdorf DJ. Exp Parasitol. 1997 Nov;87(3):229-36. PMID:9371088

Effects of troglitazone and metformin on glucose and lipid metabolism: alterations of two distinct molecular pathways. Lenhard JM, Kliewer SA, Paulik MA, Plunket KD, Lehmann JM, Weiel JE. Biochem Pharmacol. 1997 Oct 1;54(7):801-8. PMID:9353134

Activation of the orphan receptor RIP14 by retinoids. Zavacki AM, Lehmann JM, Seol W, Willson TM, Kliewer SA, Moore DD. Proc Natl Acad Sci U S A. 1997 Jul 22;94(15):7909-14. PMID:9223286

NMR spectroscopic studies of the DNA-binding domain of the monomer-binding nuclear orphan receptor, human estrogen related receptor-2. The carboxyl-terminal extension to the zinc-finger region is unstructured in the free form of the protein. Sem DS, Casimiro DR, Kliewer SA, Provencal J, Evans RM, Wright PE. J Biol Chem. 1997 Jul 18;272(29):18038-43. PMID:9218433

Activation of the orphan nuclear receptor steroidogenic factor 1 by oxysterols. Lala DS, Syka PM, Lazarchik SB, Mangelsdorf DJ, Parker KL, Heyman RA. Proc Natl Acad Sci U S A. 1997 May 13;94(10):4895-900. PMID:9144161

Retinoic acid receptor expression abnormalities in lung cancer: important clues or major obstacles? Minna JD, Mangelsdorf DJ. J Natl Cancer Inst. 1997 May 7;89(9):602-4. Review. No abstract available.  PMID:9150178

Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors alpha and gamma. Kliewer SA, Sundseth SS, Jones SA, Brown PJ, Wisely GB, Koble CS, Devchand P, Wahli W, Willson TM, Lenhard JM, Lehmann JM. Proc Natl Acad Sci U S A. 1997 Apr 29;94(9):4318-23. PMID:9113987

Peroxisome proliferator-activated receptors alpha and gamma are activated by indomethacin and other non-steroidal anti-inflammatory drugs. Lehmann JM, Lenhard JM, Oliver BB, Ringold GM, Kliewer SA. J Biol Chem. 1997 Feb 7;272(6):3406-10. PMID:9013583

Unique requirements for retinoid-dependent transcriptional activation by the orphan receptor LXR. Willy PJ, Mangelsdorf DJ. Genes Dev. 1997 Feb 1;11(3):289-98. PMID:9030682

Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway.
Lehmann JM, Kliewer SA, Moore LB, Smith-Oliver TA, Oliver BB, Su JL, Sundseth SS, Winegar DA, Blanchard DE, Spencer TA, Willson TM. J Biol Chem. 1997 Feb 7;272(6):3137-40. PMID:9013544

Discovery of ligands for the nuclear peroxisome proliferator-activated receptors. Willson TM, Lehmann JM, Kliewer SA. Ann N Y Acad Sci. 1996 Dec 27;804:276-83. PMID:8993550

Activation of the nuclear receptor peroxisome proliferator-activated receptor gamma promotes brown adipocyte differentiation. Tai TA, Jennermann C, Brown KK, Oliver BB, MacGinnitie MA, Wilkison WO, Brown HR, Lehmann JM, Kliewer SA, Morris DC, Graves RA. J Biol Chem. 1996 Nov 22;271(47):29909-14. PMID:8939934

Peroxisome proliferator-activated receptor-gamma activation by thiazolidinediones induces adipogenesis in bone marrow stromal cells. Gimble JM, Robinson CE, Wu X, Kelly KA, Rodriguez BR, Kliewer SA, Lehmann JM, Morris DC. Mol Pharmacol. 1996 Nov;50(5):1087-94. PMID:8913339

An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha. Janowski BA, Willy PJ, Devi TR, Falck JR, Mangelsdorf DJ. Nature. 1996 Oct 24;383(6602):728-31. PMID:8878485

The structure-activity relationship between peroxisome proliferator-activated receptor gamma agonism and the antihyperglycemic activity of thiazolidinediones. Willson TM, Cobb JE, Cowan DJ, Wiethe RW, Correa ID, Prakash SR, Beck KD, Moore LB, Kliewer SA, Lehmann JM. J Med Chem. 1996 Feb 2;39(3):665-8. No abstract available.  PMID:8576907

A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation. Kliewer SA, Lenhard JM, Willson TM, Patel I, Morris DC, Lehmann JM. Cell. 1995 Dec 1;83(5):813-9. PMID:8521498

The RXR heterodimers and orphan receptors. Mangelsdorf DJ, Evans RM. Cell. 1995 Dec 15;83(6):841-50. Review. No abstract available.  PMID:8521508

The nuclear receptor superfamily: the second decade. Mangelsdorf DJ, Thummel C, Beato M, Herrlich P, Schütz G, Umesono K, Blumberg B, Kastner P, Mark M, Chambon P, Evans RM.
Cell. 1995 Dec 15;83(6):835-9. Review. No abstract available.  PMID:8521507

Activation of mammalian retinoid X receptors by the insect growth regulator methoprene.
Harmon MA, Boehm MF, Heyman RA, Mangelsdorf DJ. Proc Natl Acad Sci U S A. 1995 Jun 20;92(13):6157-60. PMID:7597096

An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma). Lehmann JM, Moore LB, Smith-Oliver TA, Wilkison WO, Willson TM, Kliewer SA. J Biol Chem. 1995 Jun 2;270(22):12953-6. PMID:7768881

LXR, a nuclear receptor that defines a distinct retinoid response pathway. Willy PJ, Umesono K, Ong ES, Evans RM, Heyman RA, Mangelsdorf DJ. Genes Dev. 1995 May 1;9(9):1033-45. PMID:7744246

NMR assignments and secondary structure of the retinoid X receptor alpha DNA-binding domain. Evidence for the novel C-terminal helix. Lee MS, Sem DS, Kliewer SA, Provencal J, Evans RM, Wright PE. Eur J Biochem. 1994 Sep 1;224(2):639-50. PMID:7925381

Cross-talk among ROR alpha 1 and the Rev-erb family of orphan nuclear receptors. Forman BM, Chen J, Blumberg B, Kliewer SA, Henshaw R, Ong ES, Evans RM. Mol Endocrinol. 1994 Sep;8(9):1253-61. PMID:7838158

Differential expression and activation of a family of murine peroxisome proliferator-activated receptors. Kliewer SA, Forman BM, Blumberg B, Ong ES, Borgmeyer U, Mangelsdorf DJ, Umesono K, Evans RM. Proc Natl Acad Sci U S A. 1994 Jul 19;91(15):7355-9. PMID:8041794

Chromosomal localization of the human retinoid X receptors. Almasan A, Mangelsdorf DJ, Ong ES, Wahl GM, Evans RM. Genomics. 1994 Apr;20(3):397-403. PMID:8034312

Structure of the retinoid X receptor alpha DNA binding domain: a helix required for homodimeric DNA binding. Lee MS, Kliewer SA, Provencal J, Wright PE, Evans RM. Science. 1993 May 21;260(5111):1117-21. PMID:8388124

Vitamin A receptors. Mangelsdorf DJ. Nutr Rev. 1994 Feb;52(2 Pt 2):S32-44. Review. No abstract available.  PMID:8202281

Retinoid receptors. Mangelsdorf DJ, Kliewer SA, Kakizuka A, Umesono K, Evans RM.
Recent Prog Horm Res. 1993;48:99-121. Review. No abstract available.  PMID:8382832

Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors. Kliewer SA, Umesono K, Noonan DJ, Heyman RA, Evans RM. Nature. 1992 Aug 27;358(6389):771-4. PMID:1324435

Retinoic acid receptors initiate induction of the cytomegalovirus enhancer in embryonal cells.
Ghazal P, DeMattei C, Giulietti E, Kliewer SA, Umesono K, Evans RM. Proc Natl Acad Sci U S A. 1992 Aug 15;89(16):7630-4. PMID:1323848

Multiple retinoid-responsive receptors in a single cell: families of retinoid "X" receptors and retinoic acid receptors in the Xenopus egg. Blumberg B, Mangelsdorf DJ, Dyck JA, Bittner DA, Evans RM, De Robertis EM. Proc Natl Acad Sci U S A. 1992 Mar 15;89(6):2321-5. PMID:1312717

Characterization of three RXR genes that mediate the action of 9-cis retinoic acid. Mangelsdorf DJ, Borgmeyer U, Heyman RA, Zhou JY, Ong ES, Oro AE, Kakizuka A, Evans RM. Genes Dev. 1992 Mar;6(3):329-44. PMID:1312497

Retinoid X receptor-COUP-TF interactions modulate retinoic acid signaling. Kliewer SA, Umesono K, Heyman RA, Mangelsdorf DJ, Dyck JA, Evans RM. Proc Natl Acad Sci U S A. 1992 Feb 15;89(4):1448-52. PMID:1311101

Retinoid X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone and vitamin D3 signalling. Kliewer SA, Umesono K, Mangelsdorf DJ, Evans RM. Nature. 1992 Jan 30;355(6359):446-9. PMID:1310351

9-cis retinoic acid is a high affinity ligand for the retinoid X receptor. Heyman RA, Mangelsdorf DJ, Dyck JA, Stein RB, Eichele G, Evans RM, Thaller C. Cell. 1992 Jan 24;68(2):397-406. PMID:1310260

A direct repeat in the cellular retinol-binding protein type II gene confers differential regulation by RXR and RAR. Mangelsdorf DJ, Umesono K, Kliewer SA, Borgmeyer U, Ong ES, Evans RM. Cell. 1991 Aug 9;66(3):555-61. PMID:1651173

A direct repeat in the cellular retinol-binding protein type II gene confers differential regulation by RXR and RAR. Mangelsdorf DJ, Umesono K, Kliewer SA, Borgmeyer U, Ong ES, Evans RM. Cell. 1991 Aug 9;66(3):555-61. PMID:1651173

Characterization of DNA binding and retinoic acid binding properties of retinoic acid receptor.
Yang N, Schüle R, Mangelsdorf DJ, Evans RM. Proc Natl Acad Sci U S A. 1991 May 1;88(9):3559-63. PMID:1850832

A functional retinoic acid receptor encoded by the gene on human chromosome 12.
Ishikawa T, Umesono K, Mangelsdorf DJ, Aburatani H, Stanger BZ, Shibasaki Y, Imawari M, Evans RM, Takaku F. Mol Endocrinol. 1990 Jun;4(6):837-44. PMID:2172793

Nuclear receptor that identifies a novel retinoic acid response pathway. Mangelsdorf DJ, Ong ES, Dyck JA, Evans RM. Nature. 1990 May 17;345(6272):224-9. PMID:2159111

Jun-Fos and receptors for vitamins A and D recognize a common response element in the human osteocalcin gene. Schüle R, Umesono K, Mangelsdorf DJ, Bolado J, Pike JW, Evans RM. Cell. 1990 May 4;61(3):497-504. PMID:2159384

Identification and regulation of 1,25-dihydroxyvitamin D3 receptor activity and biosynthesis of 1,25-dihydroxyvitamin D3. Studies in cultured bovine aortic endothelial cells and human dermal capillaries. Merke J, Milde P, Lewicka S, Hügel U, Klaus G, Mangelsdorf DJ, Haussler MR, Rauterberg EW, Ritz E. J Clin Invest. 1989 Jun;83(6):1903-15. PMID:2542376

Evidence for in vivo upregulation of the intestinal vitamin D receptor during dietary calcium restriction in the rat. Favus MJ, Mangelsdorf DJ, Tembe V, Coe BJ, Haussler MR. J Clin Invest. 1988 Jul;82(1):218-24. PMID:2839546

Cloning and expression of full-length cDNA encoding human vitamin D receptor. Baker AR, McDonnell DP, Hughes M, Crisp TM, Mangelsdorf DJ, Haussler MR, Pike JW, Shine J, O'Malley BW. Proc Natl Acad Sci U S A. 1988 May;85(10):3294-8. PMID:2835767

Molecular biology of the vitamin D hormone. Haussler MR, Mangelsdorf DJ, Komm BS, Terpening CM, Yamaoka K, Allegretto EA, Baker AR, Shine J, McDonnell DP, Hughes M, et al.
Recent Prog Horm Res. 1988;44:263-305. Review. No abstract available.  PMID:2851156

Immunoselection of cDNAs to avian intestinal calcium binding protein 28K and a novel calmodulin-like protein: assessment of mRNA regulation by the vitamin D hormone.
Mangelsdorf DJ, Komm BS, McDonnell DP, Pike JW, Haussler MR. Biochemistry. 1987 Dec 15;26(25):8332-8. PMID:3442659

Molecular cloning of complementary DNA encoding the avian receptor for vitamin D.
McDonnell DP, Mangelsdorf DJ, Pike JW, Haussler MR, O'Malley BW. Science. 1987 Mar 6;235(4793):1214-7. PMID:3029866

Avian and mammalian receptors for 1,25-dihydroxyvitamin D3: in vitro translation to characterize size and hormone-dependent regulation. Mangelsdorf DJ, Pike JW, Haussler MR.
Proc Natl Acad Sci U S A. 1987 Jan;84(2):354-8. PMID:2432610

1,25-Dihydroxyvitamin D3 receptors: altered functional domains are associated with cellular resistance to vitamin D3. Pike JW, Allegretto EA, Kelly MA, Donaldson CA, Marion SL, Mangelsdorf DJ, Haussler MR. Adv Exp Med Biol. 1986;196:377-90. Review. PMID:3012980

1,25-Dihydroxyvitamin D3 receptors in space-flown vs. grounded control rat kidneys.
Mangelsdorf DJ, Marion SL, Pike JW, Haussler MR. Physiologist. 1985 Dec;28(6 Suppl):S223-4. No abstract available.  PMID:3010347

Identification and quantitation of intracellular retinol and retinoic acid binding proteins in cultured cells. Haussler MR, Donaldson CA, Kelly MA, Mangelsdorf DJ, Bowden GT, Meinke WJ, Meyskens FL, Sidell N. Biochim Biophys Acta. 1984 Feb 17;803(1-2):54-62. PMID:6320909

1,25-Dihydroxyvitamin D3-induced differentiation in a human promyelocytic leukemia cell line (HL-60): receptor-mediated maturation to macrophage-like cells. Mangelsdorf DJ, Koeffler HP, Donaldson CA, Pike JW, Haussler MR. J Cell Biol. 1984 Feb;98(2):391-8. PMID:6319426

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