About Us

Current Members

Jie Hu

Jie Hu

Research Scientist

I was born and raised in China and graduated from China Medical University with both a M.D and Ph.D. I joined Dr. Malter Lab in 2011 and my research is focused on generating conditional knockout mouse for tissue specific gene disruption, particularly in lung, eosinophils, neuron and bone. Outside the lab I enjoy reading, watching movies and spending time with my husband and kids.

 

Venkatesh Kashi

Venkatesh Kashi

Assistant Instructor

I joined Dr. Malter’s lab in 2015 as a postodoctoral fellow. The overarching goal of my research is to understand the cellular and molecular mechanisms of autoimmunity with emphasis on the role of Pin1 in asthma and pulmonary fibrosis.

 

 

 

Melissa O'Neal

Melissa O’Neal

Assistant Instructor

I joined Dr. Malter’s group in 2015 after completing my post-doctoral training in Cell Biology at UT Southwestern. My current research examines how post-translational modifications effect Pin1 activity and Pin1 protein-protein interactions in neurons. Ultimately, we are investigating if Pin1 contributes to pathways in early onset Alzheimer’s disease.

 

Zhong-Jian Shen

Zhong-Jian Shen

Instructor

I am from China and joined this lab in 2003 after completing post-doctoral fellowship in Japan, and initiated my studies on the molecular pathogenesis of allergic asthma and pulmonary fibrosis. Specifically, my research has been directed to understand how immune cells, particularly eosinophils produced cytokines and responded to receptor mediated signaling. I showed that Pin1, a peptidyl prolyl isomearase, regulates eosinophil lifespan as well as fibrotic phenotype of lung fibroblasts in rodent model of allergic asthma and human asthmatics. Currently I am pursuing the molecular mechanism by which Pin1 controls TGF super-family signaling and its roles in disease pathogenesis. These studies could lead to the identification of novel therapeutic approaches for the treatment of human diseases.