About Us

Current Members

 
Lab Members
Lab Members
Olatunde Badejo

Olatunde Badejo

Summer Fellow

I am currently an Undergraduate at Harvard University studying Molecular and Cellular Biology with plans to pursue graduate education on either an MD or MD/PHD route. I am in Dr. Malter's lab for the summer through the SURF program and am currently working on a project looking to understand how a proposed activator of PIN1 affects the pathway leading to dendritic spine loss and ultimately Alzheimer's.

Katherine Bussan

Katherine Bussan

Summer Fellow

I am a medical student at UT Southwestern working in Dr. Malter's lab through the Summer Research Program. I am looking further into the role of PIN1 in Alheimer's disease by determining the activity of mutant PIN1 proteins and determining their influence on dendritic spine count and morphology.

Jie Hu

Jie Hu

Research Scientist

I was born and raised in China and graduated from China Medical University with both a M.D and Ph.D. I joined Dr. Malter Lab in 2011 and my research is focused on generating conditional knockout mouse for tissue specific gene disruption, particularly in lung, eosinophils, neuron and bone. Outside the lab I enjoy reading, watching movies and spending time with my husband and kids.

Venkatesh Kashi

Venkatesh Kashi

Assistant Instructor

I joined Dr. Malter’s lab in 2015 as a postodoctoral fellow. The overarching goal of my research is to understand the cellular and molecular mechanisms of autoimmunity with emphasis on the role of Pin1 in asthma and pulmonary fibrosis.

Melissa O'Neal

Melissa O'Neal

Instructor

I joined Dr. Malter's group in 2015 after completing my post-doctoral training in Cell Biology at UT Southwestern. My current research examines how post-translational modifications effect Pin1 activity and Pin1 protein-protein interactions in neurons. Ultimately, we are investigating if Pin1 contributes to pathways in early onset Alzheimer's disease.

Zhong-Jian Shen

Zhong-Jian Shen

Instructor

I am from China and joined this lab in 2003 after completing post-doctoral fellowship in Japan, and initiated my studies on the molecular pathogenesis of allergic asthma and pulmonary fibrosis. Specifically, my research has been directed to understand how immune cells, particularly eosinophils produced cytokines and responded to receptor mediated signaling. I showed that Pin1, a peptidyl prolyl isomearase, regulates eosinophil lifespan as well as fibrotic phenotype of lung fibroblasts in rodent model of allergic asthma and human asthmatics. Currently I am pursuing the molecular mechanism by which Pin1 controls TGF super-family signaling and its roles in disease pathogenesis. These studies could lead to the identification of novel therapeutic approaches for the treatment of human diseases.

Nancy Stallings

Nancy Stallings

Intructor

I joined Dr. Malter’s lab in 2013 to study Pin1 in the development of Alzheimer’s Disease. Pin1 protein is marked reduced in the brains of Alzheimer’s Disease patients. Our research has focused on the regulation of Pin1 activity during the maintenance of healthy neuronal spines, hopefully giving insight on some of the early events of Alzheimer’s. Through the use of primary neuronal cultures, we have found that Pin1 activity is essential for healthy neurons. Future studies will focus on the mechanism by which Pin1 activity is regulated in neurons .