Hippo Pathway

RASSF5/Mst-2 complex
RASSF5/Mst-2 complex

We have initiated biochemical and structural studies of the Hippo pathway, which controls organ size by maintaining the delicate balance between cell proliferation and apoptosis. 

We have made great progress in structural and biochemical characterization of the core components in the Hippo pathway, including the structure determination of the downstream effector TEAD, the kinase domain of human Mst2, and the Mst2-RASSF5 complex. 

These exciting new developments form the basis for our current research, which is to determine the crystal structures of the core components of the Hippo pathway and elucidate the molecular mechanism of kinase activation and inhibition in organ size control. We use a combination of biophysical and biochemical approaches for these studies.