Publications

Highlighted Publications

  • Xiang L, Gilkes DM, Hu H, Takano N, Luo W, Lu H, Bullen JW, Samanta D, Liang H, Semenza GL. (2014) Hypoxia-inducible factor 1 mediates TAZ expression and nuclear localization to induce the breast cancer stem cell phenotype. 5(24):12509-12527.
  • Chapiro J, Sur S, Savic LJ, Ganapathy-Kaniappan S, Reyes J, Duran R, Chettiar-Thiruganasambandam S, Moats CR, Lin M, Luo W, Tran PT, Herman JM, Semenza GL, Ewald AJ, Vogelstein B, Geschwind JF. (2014) Systemic Delivery of Microencapsulated 3-Bromopyruvate for the Therapy of Pancreatic Cancer. Clin Cancer Res. 20(24):6406-6417.
  • Hu H, Takano N, Xiang L, Gilkes DM, Luo W, Semenza (2014) Hypoxia-inducible factors enhance glutamate signaling in cancer cells. Oncotarget. 5(19):8853-8868.
  • LuoW, Lin B, Wang Y, Zhong J, O'Meally R, Cole RN, Pandey A, Levchenko A, Semenza (2014) PHD3-mediated prolyl hydroxylation of non-muscle actin impairs polymerization and cell motility. Mol Biol Cell. 25(18):2788-2796.
  • Wang T, Gilkes D, Takano N, Xiang L, Luo W, Bishop C, Chaturvedi P, Green J, Semenza GL. (2014) Hypoxia-inducible factor- and Rab22a-dependent microvesicle formation promotes breast cancer invasion/metastasis. Proc Natl Acad Sci U S A. 111(31):E3234-E3242.
  • Takano N, Peng YJ, Kumar GK, Luo W, Hu H, Shimoda LA, Suematsu M, Prabhakar NR, Semenza GL. (2014) Hypoxia-inducible factors regulate human and rat cystathionine b-synthase gene expression. Biochem J. 458(2):203-211.
  • Xiang L, Gilkes DM, Chaturvedi P, Luo W, Hu H, Takano N, Liang H, Semenza GL. (2014) Ganetespib blocks HIF-1 activity and inhibits tumor growth, vascularization, stem cell maintenance, invasion, and metastasis in orthotopic mouse models of triple-negative breast cancer. J Mol Med (Berl). 92(2):151-164.
  • Cai Z*, Luo W*, Zhan H, Semenza GL. (2013) Hypoxia-inducible factor 1 is required for remote ischemic preconditioning of the heart. Proc Natl Acad Sci U S A. 110(43):17462-17467. (*Equally contributed)
  • Chen Z, Barbi J, Bu S, Yang H, Li Z, Gao Y, Jinasena D, Fu J, Lin F, Chen C, Zhang J, Yu N, Li X, Shan Z, Nie J, Gao Z, Tian H, Li Y, Yao Z, Zheng Y, Park BV, Pan Z, Zhang J, Dang E, Li Z, Wang H, Luo W, Li L, Semenza GL, Zheng S, Loser K, Tsun A, Greene M, Pardoll DM, Pan F, Li B. (2013) The ubiquitin ligase Stub1 negatively modulates regulatory T cell suppressive activity by promoting degradation of the transcription factor Foxp3. 39 (2): 272–285.
  • Chaturvedi P, Gilkes D, Wong C, Kshitiz, Luo W, Zhang H, Wei H, Takano N, Schito L, Levchenko A, Semenza GL. (2013) Hypoxia-inducible factor-dependent breast cancer-mesenchymal stem cell bidirectional signaling promotes metastasis. J Clin. Invest. 123(1):189-205.
  • Hubbi ME, Kshitiz, Gilkes DM, Rey S, Wong C, Luo W, Kim D, Dang CV, Levchenko A, Semenza GL. (2013) A nontranscriptional role for HIF-1a as a direct inhibitor of DNA replication. Signal. 6(262):ra10.
  • Luo W, Chang R, Zhong J, Pandey A, Semenza GL. (2012) Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression. Proc Natl Acad Sci U S A. 109(49):E3367-E3376.
  • Luo W and Semenza GL. (2012) Emerging roles of PKM2 in cell metabolism and cancer progression. Trends Endocrinol Metab. 23(11):560-566.
  • Luo W, Hu H, Chang R, Zhong J, Knabel M, O’Meally R, Cole R, Pandey A, Semenza GL. (2011) Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1. Cell. 145(5):732-744. (Highlighted in Cell, Nature Reviews Cancer, and Science Signaling, and selected by Faculty of 1000 as recommended paper)
  • Dang E, Barbi, J, Yang H, Jinasena D, Yu H, Zheng Y, Bordman, Z, Fu J, Kim Y, Yen H, Luo W, Zeller K, Shimoda L, Topalian S, Semenza GL, Dand CV, Pardoll D, Pan F. (2011). Control of TH17/Treg balance by hypoxia-inducible factor 1. Cell. 146(5):772-784.
  • Luo W, Semenza GL. (2011) Pyruvate kinase M2 regulates glucose metabolism by functioning as a coactivator for hypoxia-inducible factor 1 in cancer cells. Oncotarget. 2(7):551-556. (Cover article)
  • Hubbi ME, Luo W, Baek JH, Semenza GL. (2011) MCM proteins are negative regulators of hypoxia-inducible factor 1. Mol Cell. 42(5):700-712.
  • Rey S, Luo W, Shimoda LA, Semenza GL. (2011) Metabolic reprogramming by HIF-1 promotes the survival of bone marrow-derived angiogenic cells in ischemic tissue. Blood. 117(18):4988-4998
  • Yuan G, Khan SA, Luo W, Nanduri J, Semenza GL, Prabhakar NR. (2011) Hypoxia-inducible factor 1 mediates increased expression of NADPH oxidase-2 in response to intermittent hypoxia. J Cell Physiol. 226(11): 2925-2933.
  • Luo W, Wang Y, Reiser G. (2011) Proteinase-activated receptors, nucleotide P2Y receptors, and m-opioid receptor-1B are under the control of the type I transmembrane proteins p23 and p24A in post-Golgi trafficking. J Neurochem. 117(1):71-81.
  • Luo W, Zhong J, Chang R, Hu H, Pandey A, Semenza GL. (2010) Hsp70 and CHIP selectively mediate ubiquitination and degradation of hypoxia-inducible factor (HIF)-1a but not HIF-2a. J Biol Chem. 285(6):3651-3663.
  • Wang Y*, Luo W*, Reiser G. (2008) Trypsin and trypsin-like proteases in the brain: Proteolysis and cellular functions. Cell Mol Life Sci. 65(2):237-252. (* equally contributed)
  • Luo W, Wang Y, Reiser G. (2007) Protease-activated receptors in the brain: Receptor expression, activation, and functions in neurodegeneration and neuroprotection. Brain Res Rev. 56(2):331-345.
  • Wang Y, Luo W, Reiser G. (2007) Activation of protease-activated receptors in astrocytes evokes a novel neuroprotective pathway through release of chemokines of the growth-regulated oncogene/cytokine-induced neutrophil chemoattractant family. Eur J Neurosci. 26(11):3159-3168.
  • Luo W, Wang Y, Reiser G. (2007) p24A, a type I transmembrane protein, controls ARF1-dependent resensitization of protease-activated receptor-2 by influence on receptor trafficking. J Biol Chem. 282(41):30246-30255.
  • Wang Y, Luo W, Reiser G. (2007) The role of calcium in protease-activated receptor-induced secretion of chemokine GRO/CINC-1 in rat brain astrocytes. J Neurochem. 103(2):814-819.
  • Wang Y., Luo W., Reiser G. (2007) Proteinase-activated receptor-1 and proteinase-activated receptor-2 induce the release of chemokine GRO/CINC-1 from rat astrocytes via differential activation of JNK isoforms, evoking multiple protective pathways in brain. Biochem J. 401:65-78.
  • Wang Y., Luo W., Wartmann T., Halangk W., Sahin-Tόth M., Reiser G. (2006) Mesotrypsin, a brain trypsin, activates selectively proteinase-activated receptor-1, but not proteinase-activated receptor-2, in rat astrocytes. J Neurochem, 99:759-69.
  • Wang Y., Luo W., Stricker R., Reiser G. (2006) Protease-activated receptor-1 protects rat astrocytes from apoptotic cell death via JNK-mediated release of the chemokine GRO/CINC-1. J Neurochem, 98:1046-60.
  • Luo W., Wang Y., Hanck T., Stricker R., Reiser G. (2006) Jab1, a novel protease-activated receptor-2 (PAR-2)-interacting protein, is involved in PAR-2-induced activation of activator protein-1. J Biol Chem 281: 7927-36.
  • Luo W., Wang Y., Reiser G. (2005) Two types of protease-activated receptors (PAR-1 and PAR-2) mediate calcium signaling in rat retinal ganglion cells RGC-5. Brain Res 1047: 159-67.
  • Luo Wei-Bo, Dong Li, Wang Yi-Ping. (2002) Effect of magnesium lithospermate B on calcium and nitric oxide in endothelial cells upon hypoxia/reoxygenation. Acta Pharmacologica Sinica 23 (10): 930-6
  • Xu Man, Wang Yi-Ping, Luo Wei-Bo, Xuan Li-Jiang. (2001) Salvianolate inhibits proliferation and endothelin release in cultured rat mesangial cells. Acta Pharmacologica Sinica 22 (7): 629-633
  • Luo Wei-Bo, Wang Yi-Ping. (2001) Magnesium lithospermate B inhibits hypoxia-induced calcium influx and nitric oxide release in endothelial cells. Acta Pharmacologica Sinica 22 (12): 1135-1142
  • Luo Wei-Bo, Sun Fa-Neng, Wang Yi-Ping. (2001) A comparison of inhibition of pravastatin on HMG-CoA reductase with enalapril and verapamil in SDR and SHR liver. Chinese Pharmalogical Bulletin 17 (4): 386-389