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Research

Measurement of blood volume in brain and spinal cord

A vascular component is increasingly recognized as important in Alzheimer’s disease (AD). We measured cerebral blood volume (CBV) in patients with probable Alzheimer's disease (AD) or mild cognitive impairment (MCI) (n=16, 9M, 7F, age=70.7 ±9.3) and in elderly non-demented subjects (n=10, 3M, 7F, age=73.1 ±4.4) using a recently developed vascular-space-occupancy (VASO) MRI technique. While both gray and white matters were examined, significant CBV deficit regions were primarily located in white matter, specifically in frontal and parietal lobes, in which CBV was reduced by 20 percent in the AD/MCI group. The regions with CBV deficit also showed reduced tissue structural integrity as indicated by increased apparent diffusion coefficients, whereas in regions without CBV deficits no such correlation was found.

Brain scan
Results of voxel-based analysis with two sample t-test on the CBV maps of AD/MCI and control groups. The colored regions show significant CBV deficit in AD/MCI patients (p<0.005 and= minimum cluster size=1250 mm3). The color bar indicates Student t-statistic value.
Bar chart
ROI analysis results of CBV in AD/MCI and control groups. 8-mm (frontal, parietal, and occipital WM, hippocampus) or 6-mm (parietotemporal GM) diameter circles were drawn on each subject’s normalized CBV maps to obtain the mean value for each ROI.