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Publications

Publications for Hanzhang Lu, Ph.D.

  1. Lu, H., Golay, X., and van Zijl, P.C. Intervoxel Heterogeneity of Event-Related Functional Magnetic Resonance Imaging Responses as a Function of T1 Weighting. NeuroImage 17: 943-955, 2002.
  2. Lu, H., Golay, X., Pekar, J.J., and van Zijl, P.C. Functional Magnetic Resonance Imaging Based on Changes in Vascular Space Occupancy. Magnetic Resonance in Medicine 50: 263-274, 2003.
  3. Hendrikse, J., Lu, H., van der Grond, J., van Zijl, P.C., and Golay, X. Fast Measurements of Cerebral Perfusion and Arterial Hemodynamics during Visual Stimulation with TURBO-TILT fMRI. Magnetic Resonance in Medicine 50: 429-433, 2003.
  4. Lu, H., van Zijl, P.C., Hendrikse, J., Golay, X. Multiple Acquisition with Global Inversion Cycling (MAGIC): a Multi-slice Technique  for Vascular-Space-Occupancy Dependent fMRI. Magnetic Resonance in Medicine 51: 9-15, 2004.
  5. Hendrikse, J., van der Grond, J., Lu, H., van Zijl, P.C., and Golay, X. Flow territory mapping of the cerebral arteries with regional perfusion MRI (RPI). Stroke 35: 882-887, 2004.
  6. Lu, H., Golay, X., Pekar, J.J., and van Zijl, P.C. Sustained post-stimulus elevation in cerebral oxygen utilization following vascular recovery. Journal of Cerebral Blood Flow and Metabolism 24: 764-770, 2004.
  7. 7Lu, H., Clingman, C., Golay, X., and van Zijl, P.C. Determination of Longitudinal Relaxation Time (T1) of Blood at 3.0 Tesla. Magnetic Resonance in Medicine 52: 679-682, 2004.
  8. Lu, H., and van Zijl, P.C. Experimental Separation of Intra and Extravascular BOLD Effects using Multi-echo VASO and BOLD fMRI at 1.5T and 3.0T. Magnetic Resonance in Medicine 53: 808-816, 2005.
  9. Jensen, J.H., Helpern, J.A., Ramani, A., Lu, H., and Kaczynski, K. Diffusional Kurtosis Imaging: The Quantification of Non-Gaussian Water Diffusion by Means of MRI. Magnetic Resonance in Medicine 53: 1432-1440, 2005.
  10. Lu, H., Nagae-Poetscher, L.M., Golay, X., Lin D., Pomper M.G., and van Zijl, P.C. Routine Clinical Brain MRI Sequences for Use at 3.0 Tesla. Journal of Magnetic Resonance Imaging 22: 13-22, 2005.
  11. Lu, H., Basso, G., Serences, J.T., Yantis, S., Golay, X., and van Zijl, P.C. Retinotopic mapping in human visual cortex using Vascular-Space-Occupancy (VASO) dependent fMRI. NeuroReport 16: 1635-1640, 2005.
  12. Lu, H., Law, M., Johnson, G., Ge, Y., van Zijl, P.C., and Helpern, J.A. A Novel Approach to Measure Absolute Cerebral Blood Volume using Vascular-Space-Occupancy (VASO) Dependent MRI. Magnetic Resonance in Medicine 54: 1403-1411, 2005.
  13. van Laar P.J., Hendrikse, J., Golay X., Lu, H., van Osch, M.J. and van der Grond, J. In vivo Flow Territory Mapping of Majoy Brain Feeding Arteries. NeuroImage 29: 136-144. 2006.
  14. Gu, H., Lu, H., Ye, F.Q., Stein, E.A. and Yang, Y. Noninvasive Quantification of Cerebral Blood Volume in Humans during Functional Activation. NeuroImage 30: 377-387, 2006.
  15. Lu, H., Jensen, J.H., Ramani, A., and Helpern, J.A. Three-dimensional Characterization of Non-Gaussian Water Diffusion in Humans using Diffusion Kurtosis Imaging. NMR in Biomedicine 19: 236-247, 2006.
  16. Jensen, J.H., Chandra, R., Helpern, J.A., Ramani, A., Lu, H., Johnson, G., Lee, S.P., and Kaczynski, K. Magnetic Field Correlation Imaging. Magnetic Resonance in Medicine 55: 1350-1361, 2006.
  17. Strouse, J.J., Cox, C., Melhem, E., Lu, H., Kraut, M., Razumovsky, A., Yohay, K., van Zijl, P.C., Casella, J.F. Inverse Correlation Between Cerebral Blood Flow and Neurocognitive Function in Children with Sickle Cell Anemia (SCA). Blood 108: 379-381, 2006.
  18. Lu, H., Donahue, M.J., and van Zijl, P.C. Detrimental Effects of BOLD Signal in Arterial Spin Labeling fMRI at High Field Strength. Magnetic Resonance in Medicine 56: 546-552, 2006.
  19. Donahue, M.J., Lu, H., Jones, C.K., Pekar, J.J., and van Zijl, P.C. An Account of the Discrepancy between MRI and PET Cerebral Blood Flow Measures: A High-field MRI Investigation. NMR in Biomedicine 19: 1043-1054, 2006.
  20. Donahue, M.J., Lu, H., Jones, C.K., Pekar, J.J., and van Zijl, P.C. An Investigation of the VASO Contrast Mechanism Reveals a Novel Method for Quantifying Cerebral Blood Flow. Magnetic Resonance in Medicine 56: 1261-1273, 2006.
  21. Jensen, J.H., Lu, H., and Inglese, M. Microvessel Density Estimation in Human Brain by Means of Dynamic Contrast-Enhanced Echo Planar Imaging. Magnetic Resonance in Medicine 56: 1145-1150, 2006.
  22. Prabhakaran, V., Raman, S., Grunwald, M., Mahadevia, A., Hussain, N., Lu, H., van Zijl,  P.C., Hillis, A.E. Neural substrates of word generation during stroke recovery: the influence of cortical hypoperfusion. Behavioral Neurology 18: 45-52, 2007.
  23. Thakur, P.H., Lu, H., Hsiao, S.S., Johnson, K.O. Automated optimal detection and classification of neural action potentials in extra-cellular recordings. J Neurosci Methods 162(1-2):364-76 2007.
  24. Ge, Y., Jensen, J.H., Lu, H., Helpern, J.A., Miles, L., Inglese, M, Babb, J., Herbert, J., Grossman, R. Quantitative Assessment of Iron Accumulation in the Deep Gray Matter of Multiple Sclerosis by Magnetic Field Correlation Imaging. American Journal of Neuroradiology AJNR 28: 1639-1644, 2007.
  25. Lu, H., Law, M., Hesseltine, S.M., Rapalino, O., Ge, Y., Jensen, J.H., and Helpern, J.A. Quantitative Measurement of Spinal Cord Blood Volume in Humans using Vascular-Space-Occupancy MRI, NMR in Biomedicine, 21: 226-232, 2008.
  26. Lu, H., Pollack, E., Young, R., Babb, J. Johnson, G., Jensen, J.H., Helpern, J.A., and Law, M. Predicting Grade of Cerebral Glioma using Vascular-Space-Occupancy MRI, American Journal of Neuroradiology AJNR, 29: 373-378, 2008.
  27. Newsome, M.R., Steinberg, J.L., Scheibel, R.S., Troyanskaya, M., Chu, Z., Hanten, G., Lu, H., Lane, S., Lin, X., Hunter, J.V., Vasquez, C., Zientz, J., Li, X., Wilde, E.A., and Levin, H.S. Effects of traumatic brain injury on working memory-related brain activation in adolescents, Neuropsychology 22: 419-425, 2008.
  28. Lu, H., and Ge, Y. Quantitative evaluation of cerebral venous oxygenation using T2-Relaxation-Under-Spin-Tagging (TRUST) MRI, Magnetic Resonance in Medicine, 60: 357-363, 2008.
  29. Lu, H., Zhao, C., Ge, Y., and Lewis-Amezcua, K. Baseline blood oxygenation modulates response amplitude: physiologic basis for inter-subject variations in fMRI signals, Magnetic Resonance in Medicine, 60: 364-372, 2008.
  30. Lin, A.L., Fox, P.T., Yang, Y., Lu, H., Tan, L.H., and Gao, J.H. Evaluation of MRI Models in the Measurement of CMRO2 and its Relationship with CBF. Magnetic Resonance in Medicine, 60:380-389, 2008.
  31. Lu, H., and Yang, Y. Neuroimaging Methods Using Nuclear Magnetic Resonance. In Neurobiology of Mental Illness, Eds. Charney and Nestler. Oxford Press, 2008.
  32. Lin, A.L., Fox, P.T., Yang, Y., Lu, H., Tan, L.H., and Gao, J.H. Time-dependent Correlation of Cerebral Blood Flow with Oxygen Metabolism in Activated Human Visual Cortex as Measured by fMRI, NeuroImage, 44:16-22, 2009.
  33. Jensen, J.H., Szulc, K., Hu, C., Ramani, A., Lu, H., Xuan, L., Falangola, M.F., Chandra, R., Knopp, E., Schenck, J., Zimmerman, E.A., Helpern, J.A. Magnetic Field Correlation as a Measure of Iron-Generated Magnetic Field Inhomogeneities in the Brain, Magnetic Resonance in Medicine, 61:481-485, 2009.
  34. Uh, J., Lewis-Amezcua, K., Varghese, R., Lu, H. On the measurement of absolute cerebral blood volume using Vascular-Space-Occupancy MRI, Magnetic Resonance in Medicine, 61: 659-667, 2009.
  35. Uh, J., Lewis-Amezcua, K., Martin-Cook, K., Cheng, Y., Weiner, M., Diaz-Arrastia, R., Devous, M., Shen, D., Lu, H. Cerebral Blood Volume in Alzheimer's Disease and Correlation with Tissue Structural Integrity, Neurobiology of Aging, 31: 2038-46, 2010.
  36. Xu, F., Ge, Y., Lu, H. Non-invasive Quantification of Whole-brain Cerebral Metabolic Rate of Oxygen by MRI, Magnetic Resonance in Medicine, 62: 141-148, 2009.
  37. Yezhuvath, U., Lewis-Amezca, K. Varghese, R., Xiao, G., Lu, H. On the assessment of cerebrovascular reactivity using hypercapnia BOLD MRI, NMR in Biomedicine, 22:779-786, 2009.
  38. Lu, H., Yezhuvath, U, Xiao, G. Improving fMRI sensitivity by normalization of basal physiologic state, Human Brain Mapping, 31: 80-87, 2010.
  39. Newsome, M.R., Scheibel, R.S., Hanten, G., Chu, Z., Steinberg, J.L., Hunter, J.V., Lu, H., Vasquez, A.C., Li, X., Lin, X., Cook, L., Levin, H.S. Brain Activation while Thinking about the Self from Another Person’s Perspective after Traumatic Brain Injury in Adolescents, Neuropsychology, 24:139-147, 2010.
  40. Petersen, E.T., Mouridsen, K., Golay, X. on behalf of all named co-authors of the QUASAR test-retest study. The QUASAR reproducibility study, Part II: Results from a multi center Arterial Spin Labeling test-retest Study, NeuroImage, 49: 104-113, 2010.
  41. Aslan, S., Xu, F., Wang, P.L., Uh, J., Yezhuvath, U.S., van Osch, M., Lu, H. Estimation of labeling efficiency in pseudo-continuous arterial spin labeling, Magnetic Resonance in Medicine, 63:765-771, 2010.
  42. Yezhuvath, U.S.,Uh, J., Cheng, Y., Martin-Cook, K, Weiner, M, Diaz-Arrastia, R, van Osch, M., Lu, H. Forebrain-dominant deficit in cerebrovascular reactivity in Alzheimer's Disease, Neurobiology of Aging, 33: 75-82, 2012.
  43. Aslan, S. and Lu, H. On the sensitivity of ASL MRI in detecting regional differences in cerebral blood flow, Magnetic Resonance Imaging, 28:928-935, 2010.
  44. Uh, J., Yezhuvath, U., Cheng, Y., and Lu, H. In vivo vascular hallmarks of diffuse leukoaraiosis. Journal of Magnetic Resonance Imaging, 32: 184-190, 2010.
  45. 45. Choi, C., Ghose, S., Uh, J., Patel, A., Dimitrov, I.E., Lu, H., Douglas, D., Ganji, S. Measurement of N-acetylaspartylglutamate in the Human Frontal Brain by 1H MRS at 7T, Magnetic Resonance in Medicine, 64: 1247-1251, 2010.
  46. Liu, P., Uh, J., Lu, H. Determination of spin compartment in Arterial Spin Labeling MRI, Magnetic Resonance in Medicine, 65: 120-127, 2011.
  47. Xu, F., Uh, J., Brier, M.R., Hart, J., Yezhuvath, U.S., Gu, H., Yang, Y., and Lu, H. The influence of carbon dioxide on brain activity and metabolism in conscious humans, Journal of Cerebral Blood Flow and Metabolism, 31:58-67, 2011.
  48. Uh, J., Lin, A.L., Lee, K., Liu, P., Fox, P.T., Lu, H. Validation of VASO Cerebral Blood Volume Measurement with Positron Emission Tomography, Magnetic Resonance in Medicine, 65:744-749, 2011.
  49. Lu, H., Xu, F., Rodrigue, K.M., Kennedy, K.M., Cheng, Y., Flicker, B., Hebrank, A.C., Uh, J., and Park, D.C. Alterations in cerebral metabolic rate and blood supply across the adult lifespan, Cerebral Cortex, 21:1426-1434, 2011.
  50. van Osch, M.J.P., Lu, H. Arterial spin labeling perfusion MRI in Alzheimer’s Disease, Current Medical Imaging Reviews, 7:62-72, 2011.
  51. Liu, P., Aslan, S., Li, X., Buhner, D.M., Spence, J., Briggs, R.W., Haley, R.W., Lu, H. Perfusion deficit to cholinergic challenge in veterans with Gulf War Illness, Neurotoxicology, 32:242-246, 2011.
  52. Lu, H., Hutchison, J., Xu, F., Rypma, B. The relationship between M in “calibrated fMRI” and the physiologic modulators of fMRI, The Open Neuroimaging Journal, 5:112-119, 2011.
  53. Lin, A.L., Lu, H., Fox, P.T., Duong, T.Q. Cerebral Blood Volume Measurements – Gd_DTPA vs. VASO - and Their Relationship with Cerebral Blood Flow in Activated Human Visual Cortex, The Open Neuroimaging Journal, 5:90-95, 2011.
  54. Kozel, F.A., Rao, U., Lu, H., Nakonezny, P.A., Grannemann, B., McGregor, T., Croarkin, P.E., Mapes, K.S., Tamminga, C.A., Trivedi, M.H. Functional connectivity of brain structures correlates with treatment outcome in Major Depressive Disorder, Frontiers in Neuropsychiatric Imaging and Stimulation, 2:7, 2011.
  55. Aslan, S., Huang, H., Uh, J., Mishra, V., Xiao, G., van Osch, M.J.P., and Lu, H. White matter cerebral blood flow is inversely correlated with structural and functional connectivity in the human brain, NeuroImage, 56:1145-53, 2011.
  56. Lu, H., Xu, F., Grgac, K., Liu, P., Qin, Q., and van Zijl, P. Calibration and validation of TRUST MRI for the estimation of cerebral blood oxygenation, Magnetic Resonance in Medicine, 67:42:49, 2012.
  57. Xu, F., Uh, J., Liu, P., Lu, H. On improving the speed and reliability of T2-Relaxation-Under-Spin-Tagging (TRUST) MRI, Magnetic Resonance in Medicine, 68:198-204, 2012.
  58. Liu, P., Uh, J., Devous, M.D., Adinoff, B., Lu, H. Comparison of relative CBF maps using pseudo-continuous ASL and SPECT, NMR in Biomedicine, 25:779-786, 2012.
  59. Tao, R., Emslie, G.J., Calley, C.S., Hart, J., Mayes, T.L., Nakonezny, P.A., Lu, H., Kennard, B.D., Tamminga, C.A. Brain Activity in Adolescent Major Depressive Disorder: Pre- and Post-Fluoxetine Treatment, The American Journal of Psychiatry, 169:381-388, 2012.
  60. Newsome, M.R., Scheibel, R.S., Chu, Z., Hunter, J.V., Li, X., Wilde, E.A., Lu, H., Lin, X., Steinberg, J.L., Vasquez, A.C., Cook, L., Wang, Z.J., Levin, H.S. The Relationship of Resting Cerebral Blood Flow and Brain Activation during a Social Cognition Task in Adolescents with Chronic Moderate to Severe Traumatic Brain Injury: A Preliminary Investigation, International Journal of Developmental Neuroscience, 30:255-266, 2012.
  61. Ge, Y., Zhang, Z., Lu, H., Tang, L., Jaggi, H., Herbert, J., Babb, J., Rusinek, H., Grossman, R. Characterizing Brain Oxygen Metabolism in Patients with Multiple Sclerosis with T2-Relaxation-Under-Spin-Tagging (TRUST) MRI. J Cereb Blood Flow Metab 32:403-412, 2012.
  62. Lu, H., van Zijl, P. A review of the development of Vascular-Space-Occupancy (VASO) fMRI, NeuroImage 62:736-742, 2012.
  63. van Zijl, P., Hua, J., Lu, H. The BOLD post-stimulus undershoot, one of the most debated issues in fMRI, NeuroImage 62: 1092-1102, 2012.
  64. Liu, P., Hebrank, A.C., Rodrigue, K.M., Kennedy, K.M., Park, D.C., Lu, H. A comparison of physiologic modulators of fMRI signals, Human Brain Mapping 2012; In press.
  65. Liu, P., Xu, F. and Lu, H. Test-retest reproducibility of a rapid method to measure brain oxygen metabolism, Magnetic Resonance in Medicine 69:675-681, 2013.
  66. Xu, F., Liu, P., Pascual, J.M., Xiao, G., and Lu H. Effect of hypoxia and hyperoxia on cerebral blood flow, blood oxygenation, and oxidative metabolism, Journal of Cerebral Blood Flow and Metabolism 32:1909-1918, 2012.
  67. Jeon, T., Mishra, V., Uh, J., Weiner, M.F., Hatanpaa, K., White, C., Zhao, Y.D., Lu, H., Diaz-Arrastia, R., and Huang H. Regional changes of cortical mean diffusivities with aging after correction of partial volume effects, NeuroImage, 62: 1705-1716, 2012.
  68. Hutchison, J.L., Lu, H., Rypma, B. Neural mechanisms of age-related slowing: The ΔCBF/ΔCMRO2 ratio mediates age-differences in BOLD signal and human performance, Cerebral Cortex, 2012, In press.
  69. Brown, E.S., Lu, H., Denniston, D., Uh, J., Thomas, B.P., Carmody, T.J., Auchus, R.J., Diaz-Arrastia, R., Tamminga C.A. A randomized, placebo-controlled proof-of-concept, crossover trial of phenytoin for hydrocortisone-induced declarative memory changes, Journal of Affective Disorders, 2013, In press.
  70. Lu, H., Hua, J., van Zijl, P.C. Noninvasive functional imaging of cerebral blood volume with vascular-space-occupancy (VASO) MRI. NMR in Biomedicine, 2013, In press.
  71. Hart, J., Kraut, M.A., Womack, K.B., Strain, J., Didehbani, N., Bartz, E., Conover, H., Mansinghani, S., Lu, H., Cullum, C.M. Neuroimaging of Cognitive Dysfunction and Depression in Aging Retired National Football League Players: A Cross-sectional Study., JAMA Neurology 7:1-10, 2013.
  72. Tseng, B.Y., Uh, J., Rossetti, H.C., Cullum, C.M., Diaz-Arrastia, R.F., Levine, B.D., Lu, H., Zhang, R. Exhibit Larger Regional Brain Volume and Better Cognitive Performance than Sedentary Older Adults, Journal of Magnetic Resonance Imaging, 2013, In press.
  73. Thomas, B.P., Yezhuvath, U., Tseng, B.Y., Liu, P., Levine, B.D., Zhang, R., Lu, H. Life-long aerobic exercise preserved baseline cerebral blood flow but reduced vascular reactivity to CO2, Journal of Magnetic Resonance Imaging, 2013, In press.
  74. Krishnamurthy, L.C., Liu, P., Ge, Y., and Lu, H. Vessel-specific quantification of blood oxygenation with T2-Relaxation-Under-Phase-Contrast (TRU-PC) MRI. Magnetic Resonance in Medicine, 2013, In press.