My laboratory focuses on elucidating functions of Klotho and its related protein beta-Klotho.
The klotho gene functions as an aging-suppressor gene that extends life span when overexpressed and accelerates the development of aging-like phenotypes in mice. Klotho regulates multiple metabolic processes, notably phosphate and vitamin D metabolism.
Beta-Klotho is involved in the regulation of bile acid, fatty acid, and glucose metabolism. Klotho and beta-Klotho do these jobs primarily through regulating the activity of FGF19-subfamily of hormones.
The long-term goal of my laboratory is to understand molecular mechanisms by which these endocrine FGFs and Klotho family proteins regulate metabolism and aging.