Publications

Publications for Dr. Jin Jiang

  1. Zizhang Zhou, Xia Yao, Shuang Li, Yue Xiong, Xiaohua Dong, Yun Zhao, Jin Jiang*, and Qing Zhang.* 2015. Deubiquitination of Ci/Gli by Usp7/HAUSP regulates Hedgehog Signaling. Developmental Cell 6;34(1):58-72.
  2. Yuhong Han, Qing Shi, and Jin Jiang. Multisite interaction with Sufu regulates Ci/Gli activity through distinct mechanisms in Hh signal transduction. PNAS 112(20):6383-8.
  3. Tian A, Shi Q, Jiang A, Li SX, Wang B, Jiang, J. 2015. Injury-stimulated Hedgehog signaling promotes regenerative proliferation of Drosophila intestinal stem cells. J Cell Biol 208(6), 807-19.
  4. Qing Shi, Shuang Li, Shuangxi Li, Alice Jiang, Yongbin Chen, Jin Jiang. 2014 Hedgehog-induced phosphorylation by CK1 sustains the activity of Ci/Gli activator. PNAS 111(52), E5651-60.
  5. Li Q, Li S, Mana-Capelli S, Roth Flach RJ, Danai LV, Amcheslavsky A, Nie Y, Kaneko S, Yao X, Chen X, Cotton JL, Mao J, McCollum D, Jiang, J, Czech MP, Xu L, Ip YT. 2014. The conserved misshapen-warts-yorkie pathway acts in enteroblasts to regulate intestinal stem cells in Drosophila. Developmental Cell 31(3):291-304.
  6. Li S, Jiang C, Pan J, Wang X, Jin J, Zhao L, Pan W, Liao G, Cai X, Li X, Xiao J, Jiang, J*, Wang P*. 2014. Regulation of c-Myc protein stability by proteasome activator REGγ. Cell Death & Differentiation 22(6):1000-11..
  7. Jiang K, Liu Y, Fan J, Epperly G, Gao T, Jiang, J, Jia J. 2014. Hedgehog-regulated atypical PKC promotes phosphorylation and activation of Smoothened and Cubitus interruptus in Drosophila. PNAS 111(45), E4842-50.
  8. Hu L, Huang H, Li J, Yin MX, Lu Y, Wu W, Zeng R, Jiang, J, Zhao Y, Zhang L. 2014. Drosophila casein kinase 2 (CK2) promotes warts protein to suppress yorkie protein activity for growth control. JBC 289(48), 33598-607.
  9. Shuang Li, Guoqiang Ma, Bing Wang, Jin Jiang. 2014. Hedgehog induces formation of PKA-Smoothened complexes to promote Smoothened phosphorylation and pathway activation. Science Signaling 7(332), ra62.
  10. Chen Liu, Zizhang Zhou, Xia Yao, Ping Chen, Man Sun, Miya Su, Cunjie Changļ¼ŒJun Yan, Jin Jiang* and Qing Zhang*. 2014. Hedgehog signaling downregulates Suppressor of Fused through the HIB/SPOP-Crn axis in Drosophila. Cell Res 24(5):595-609.
  11. Aiguo Tian and Jin Jiang. 2014. Intestinal epithelium-derived BMP controls stem cell self-renewal in Drosophila adult midgut. eLife3:e01857. doi: 10.7554/eLife.01857.
  12. Qing Shi, Yuhong Han, and Jin Jiang. 2014. Suppressor of fused impedes Ci/Gli nuclear import by opposing Trn/Kapβ2 in Hedgehog signaling. Journal of Cell Science 127(5):1092-1103.
  13. Zhang Y, Fu L, Qi X, Zhang Z, Xia Y, Jia J, Jiang, J, Zhao Y, Wu G. 2013. Structural insight into the mutual recognition and regulation between Suppressor of Fused and Gli/Ci. Nature Communication 12;4:2608.
  14. Gilder AS, Chen YB, Jackson RJ 3rd, Jiang, J, Maher JF. 2013. Fem1b promotes ubiquitylation and suppresses transcriptional activity of Gli1. Biochem Biophys Res Commun 440 (3), 431-436.
  15. Fangfang Ren, Qing Shi, Yongbin Chen, Alice Jiang, Y. Tony Ip, Huaqi Jiang, and Jin Jiang. 2013. Drosophila Myc integrates multiple signaling pathways to regulate intestine stem cell proliferation during midgut regeneration. Cell Res 23(9), 1133-46.
  16. Hongling Huang, Shimin Wang, Meng-Xin Yin, Liang Dong, Chao Wang, Wei Wu, Yi Lu, Miao Feng, Chuanyang Dai, Xiaocan Guo, Li Li, Bin Zhao, Zhaocai Zhou, Hongbin Ji, Jin Jiang, Yun Zhao, Xin-Yuan Liu and Lei Zhang. 2013. Par-1 Regulates Tissue Growth by Phosphorylating Hippo and Influencing the Function of Hippo-Salvador Complex. PLoS Biol 11(8):e1001620. doi: 10.1371/journal.pbio.1001620.
  17. Zhao Zhang, Xiangdong Lv, Jin Jiang, Lei Zhang, Yun Zhao. 2013. Dual role of Hh signaling in the regulation of somatic stem cell self-renewal and germline stem cell maintenance in Drosophila testis. Cell Res 4, 573-576.
  18. Yongbin Chen and Jin Jiang. 2013. Decoding the phosphorylation code in Hedgehog signal transduction. Cell Res 2, 186-200.
  19. Cuiping Yang, Wenlin Chen, Yongbin Chen and Jin Jiang. 2012. Smoothened transduces Hedgehog Signal by forming a complex with Evc/Evc2. Cell Res 22:1593–1604.
  20. 55. Tao Yue, Aiguo Tian, and Jin Jiang. 2012. The cell adhesion molecule Echinoid functions as a tumor suppressor and upstream regulator of the Hippo signaling pathway. Developmental Cell 22, 255-267.
  21. Yuxiao Wang, Huawei He, Nishi Srivastava, Sheikh Vikarunnessa, Yongbin Chen, Jin Jiang, Christopher Cowan & Xuewu Zhang. 2012. Plexins are GTPase Activating Proteins for Rap and Activated by Induced Dimerization. Science Signaling 5(207):ra6.
  22. Yunyun Jin, Liang Dong, Yi Lu, Wenqing Wu, Qian Hao, Zhaocai Zhou, Jin Jiang, Yun Zhao and Lei Zhang. 2012. Dimerization and cytoplasmic localization regulate Hippo kinase signaling activity in organ size control. Journal of Biological Chemistry 287, 5784-96.
  23. Shuang Li, Yongbin Chen, Qing Shi, Tao Yue, Bing Wang, and Jin Jiang, 2012. Hedgehog-regulated Ubiquitination Controls Smoothened Trafficking and Cell Surface Expression in Drosophila. PLoS Biol 10(1): e1001239. doi:10.1371/journal.pbio.1001239.
  24. Chi-chung Hui and Jin Jiang. 2011. Hedgehog signaling activation in human cancer and its clinical implications. Springer Book Chapter, 1-17.
  25. Qing Shi, Shuang Li, Jianhang Jia and Jin Jiang. 2011. Hedgehog-induced Smoothened conformational switch assembles a signaling complex that activates Fused by promoting its dimerization and phosphorylation. Development 138, 4219-4231.
  26. Sheu-Fen Lee, Bhooma Srinivasan, Chantelle F. Sephton, Daniel R. Dries, Bing Wang, Colleen M. Dewey, Cong Yu, Pradip K. Majumder, Sanjiv Shah, Jin Jiang, and Gang Yu. 2011. Gamma-secretase-regulated proteolysis of notch by mitochondrial intermediate peptidase. Journal of Biological Chemistry 286, 27447-53.
  27. Yongbin Chen, Noriaki Sasai, Guoqiang Ma, Tao Yue, Jianhang Jia, James Briscoe and Jin Jiang. 2011. Sonic Hedgehog Dependent Phosphorylation by CK1a and GRK2 is Required for Ciliary Accumulation and Activation of Smoothened. PLoS Biol 9(6): e1001083. doi:10.1371/journal.pbio.1001083
  28. Alla Amcheslavsky, Naoto Ito, Jin Jiang and Y. Tony Ip. 2011. Tuberous Sclerosis Complex restricts the growth but promotes the division of intestinal stem cells in Drosophila. Journal of Cell Biology 193, 695-710.
  29. Hongge Jia, Yajuan Liu, Ruohan Xia, Chao Tong, Tao Yue, Jin Jiang, and Jianhang Jia. 2010. Casein Kinase 2 Promotes Hedgehog Signaling by Regulating both Smoothened and Cubitus Interruptus. Journal of Biological Chemistry 48, 37218-26.
  30. Fangfang Ren, Bing Wang, Tao Yue, Eun-Young Yun, Y.Tony Ip & Jin Jiang. 2010. Hippo signalingregulates Drosophila intestine stem cell proliferation through multiple pathways. PNAS 107(49):21064-9.
  31. Yongbin Chen, Shuang Li, Chao Tong, Bing Wang, Yajuan Liu, Jianhang Jia and Jin Jiang. 2010. G protein coupled receptor kinase 2 regulates high-level Hedgehog signaling by promoting the active state of Smo through both kinase dependent and independent mechanisms. Genes & Development, 24, 2054-2067.
  32. Hai Song, Kingston Mak, Lilia Topol, Kangsun Yun, Jianxin Hu, Lisa Garrett, Yongbin Chen, Ogyi Park, Jia Chang, R. Mark Simpson, Cun-Yu Wang, Bin Gao, Jin Jiang and Yingzi Yang. 2010. Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression. PNAS 107(4):1431-6.
  33. Fangfang Ren, Lei Zhang, and Jin Jiang. 2010. Hippo signaling regulates Yorkie nuclear localization and activity through 14-3-3 dependent and independent mechanisms. Dev Biology 337, 303-312.
  34. Qing Zhang, Qing Shi, Yongbin Chen, Tao Yue, Shuang Li, Bing Wang, and Jin Jiang. 2009. Multiple Ser/Thr rich degrons mediate the degradation of Ci/Gli by the Cul3-HIB/SPOP E3 ubiquitin ligase. PNAS 106, 21191-21196.
  35. Joel M. Hyman, Ari J. Firestone, Vivi M. Heine, Yun Zhao, Cory A. Ocasio, Kyuho Han, Mark Sun, Paul G. Rack, Surajit Sinha, Jason J. Wu, David E. Solow-Cordero, Jin Jiang, David H. Rowitch, James K. Chen. 2009. Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade. PNAS 106, 14132-14137.
  36. Lei Zhang, Tao Ye, and Jin Jiang. 2009. Hippo signaling pathway and organize size control. Fly 7, 68-73.
  37. Galletti Margherita, Riccardo Sara, Parisi Federica, Lora Carlina, Rivas Leinny, Wong Bonnie1, Serra Alexis, Serras Florenci, Grifoni Daniela, Pelicci PierGiuseppe, Jin Jiang, and Bellosta Paola. 2009. Identification of Domains Responsible for Ubiquitin-dependent Degradation of dMyc by GSK3b and CKI kinases. Molecular and Cellular Biology 12, 3424-3434.
  38. Hongbo Yang, Jing Xiang, Nengdong Wang, Yun Zhao4 Joel Hyman, Jin Jiang, James K. Chen, Zhen Yang, and Shuo Lin. 2009. Converse conformational control of smoothened activity by structurally related small molecules. Journal of Biological Chemistry 31, 20876-84.
  39. Alla Amcheslavsky, Jin Jiang, Y. Tony Ip. 2009. Tissue damage-induced intestinal stem cell division in Drosophila. Cell Stem Cell 4, 49-61.
  40. Jin Jiang and C-C Hui. 2008. Hedgehog Signaling in Development and Cancer. Developmental Cell 15 801-812.
  41. Lei Zhang, Fangfang Ren, Qing Zhang, Yongbin Chen, Bing Wang, and Jin Jiang. 2008. The TEAD/TEF family of transcription factor Scalloped mediates Hippo signaling in organ size control. Developmental Cell 14, 377-387.
  42. Yun Zhao, Chao Tong, and Jin Jiang. 2007. Transducing the Hedgehog Signal across the plasma membrane. Fly 6, 333-336.
  43. Yun Zhao, Chao Tong, and Jin Jiang. 2007. Hedgehog regulates Smoothened activity by inducing a conformational switch. Nature(article) 450, 252-258.
  44. Yajuan Liu, Xuesong Cao, Jin Jiang, and Jianhang Jia. 2007. Fused-Costal2 protein complex regulates Hedgehog-induced Smo phosphorylation and cell-surface accumulation. Genes & Development 21(15):1949-63.
  45. Chan-Yen Ou, Chien-Hsiang Wang, Jin Jiang, Cheng-Ting Chien. 2007. Suppression of Hedgehog signaling by Cul3 ligases in proliferation control of retinal precursors, Developmental Biology 308(1):106-119
  46. Lei Zhang, Jianhang Jia, Bing Wang, Kazuhito Amanai, Keith A. Wharton, Jr.1, and Jin Jiang. 2006. Regulation of Wingless signaling by the CKI family in Drosophila limb development. Developmental Biology 299 (1): 221-237.
  47. Chao Tong and Jin Jiang. Using Immunoprecipitation to Study Protein-protein Interactions in Hedgehog Signaling Pathway, Methods in Molecular Biology 397, 215-229.
  48. Jin Jiang. Regulation of Hh/Gli Signaling by Dual Ubiquitin Pathways. Cell Cycle 5 (21), 2457 - 2463.
  49. Jianhang Jia and Jin Jiang. 2006. Decoding the Hedgehog Signal in Animal Development. Cell and Molecular Life Science 63 (11), 1249-65.
  50. Qing Zhang, Lei Zhang, Bing Wang, Chan-Yen Ou, Cheng-Ting Chien, and Jin Jiang. 2006. A Hedgehog-induced BTB protein modulates Hedgehog signaling responses by degrading Ci/Gli transcription factor. Developmental Cell 10, 719-729.
  51. Jianhang Jia, Lei Zhang, Qing Zhang, Chao Tong, Bing Wang, Fajian Hou, Kazuhito Amanai, and Jin Jiang. 2005. Phosphorylation of Cubitus interruptus by Double-time/CKIa and CKIa targets it for Slimb/b-TRCP mediated proteolytic processing. Developmental Cell 9, 819-830.
  52. Atish Ganuly, Jin Jiang, and Y. Tony IP. 2005. Drosophila WntD is a target and an inhibitor of the Dorsal/Twist/Snail network in the gastrulating embryo. Development 132, 3419-3429
  53. Wensheng Zhang, Yun Zhao, Chao Tong, Geling Wang, Bing Wang, Jianhang Jia, and Jin Jiang. 2005. Hedgehog-regulated Costal2/kinase complexes control phosphorylation and proteolytic processing of Cubitus interruptus. Developmental Cell 8, 267-278.
  54. Jianhang Jia, Chao Tong, Bing Wang, Liping Luo and Jin Jiang. 2004. Hedgehog Signalling Activity of Smoothened Requires Phosphorylation by Protein Kinase A and Casein Kinase I. Nature 432, 1045-1050.
  55. Gelin Wang and Jin Jiang. 2004. Multiple Cos2/Ci interactions regulate Ci subcellular localization through microtubule dependent and independent mechanisms. Developmental Biology 268, 493-505.
  56. Jianhang Jia, Wensheng Zhang, Bing Wang, Richard Trinko, and Jin Jiang. 2003. The Drosophila Ste20 family kinase dMST functions as a tumor suppressor by restricting cell proliferation and promoting apoptosis. Genes & Development 17, 2709-2720.
  57. Jianhang Jia, Chao Tong, and Jin Jiang. 2003. Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its carboxyl-terminal tail. Genes & Development 17, 2514-2519.
  58. Correia T, Papayannopoulos V, Panin V, Woronoff P, Jiang, J, Vogt TF, Irvine KD. 2003. Molecular genetic analysis of the glycosyltransferase Fringe in Drosophila. Proc Natl Acad Sci 100(11), 6404-9.
  59. Jin Jiang. Degrading Ci: Who is Cul-pable? Genes & Development 16, 2315-2321.
  60. Hyuk Wan Ko, Jin Jiang, and Isaac Edery. 2002. A role for Slimb in the degradation of Drosophila PERIOD protein phosphorylated by DOUBLETIME. Nature 420, 673-678.
  61. Kazuhito Amanai and Jin Jiang. 2001. Distinct roles of Central missing and Disptached in sending the Hedgehog signal. Development 128, 5119-27.
  62. Jianhang Jia, Kazuhito Amanai, Gelin Wang, Bing Wang, Jiong Tan, and Jin Jiang. 2002. Sgg/GSK-3 inhibits Hedgehog signaling by regulating Cubitus interruptus. Nature 416, 548-52.
  63. Gelin Wang, Kazuhito Amanai, Bing Wang, and Jin Jiang. 2000. Interactions with Costal2 and Suppressor of fused regulate nuclear translocation and activity of Cubitus interruptus. Genes & Development 14: 2893-2905.
  64. Wang, G., Wang, B., and Jiang, J. 1999. PKA antagonizes Hedgehog Signaling by regulating both the activator and repressor forms of Cubitus interruptus. Genes & Development 13:2828-2837.
  65. Erika Spencer, Jin Jiang, and Zhijian J. Chen. 1999. Signal-induced ubiquitination of IkBa by the F-box protein, Slimb/ b-TrCP. Genes & Development 13:284-294.
  66. Jin Jiang and Gary Struhl. 1998. Regulation of the Hedgehog and Wingless signaling pathways by the F-box/WD40 protein Slimb.Nature 391, 493-496.
  67. Jin Jiang and Gary Struhl. 1996. Complementary and mutually exclusive activities of Decapentaplegic and Wingless organize axial patterning during Drosophila leg development. Cell 86, 401-409.
  68. Jin Jiang and Gary Struhl. 1995. Protein Kinase A and Hedgehog Signaling in Drosophila Limb Development. Cell 80, 563-572.
  69. Jin Jiang and Michael Levine. 1993. Binding affinities and cooperative interactions with bHLH activators delimit threshold responses to the Dorsal gradient morphogen. Cell 72, No.5, 741-752.
  70. Jin Jiang, Hai-ni Cai, Qing Zhou, and Michael Levine. 1993. Conversion of a silencer into an enhancer: evidence for dorsal corepresseos. EMBO J. Vol. 12, No.8, 3201-3210.
  71. Jin Jiang, Christine Rushlow, Qing Zhou, Steve Small, and Michael Levine. 1992. Individual dorsal binding sites mediate activation and repression in the Drosophila embryo. EMBO J. Vol.11, No.8, 3147-3154.
  72. Jin Jiang, David Kosman, Tony Ip, and Michael Levine. 1991. The dorsal morphogen gradient regulates the mesoderm determinanttwist in Drosophila early embryo. Genes & Development 5:1881-1891.
  73. Jin Jiang, Timothy Hoey, and Michael Levine. 1991. Autoregulation of a segmentation gene in Drosophila: combinatorial interaction of the eve-skipped homeo box protein with a distal enhancer element. Genes & Development 5:265-277.
  74. Jin Jiang, Baohua Gu, Lisa M. Albright, and Tracy Nixon. Conservation between Coding and Regulatory Elements of Rhizobium meliloti and Rhizobium leguminosarum dct. Journal of Bacteriology, Oct., 1989, p. 5244-5253.w

(*co-corresponding authors)