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Nutrient Sensing

The Jewell lab investigates how organisms sense the availability of nutrients, such as amino acids, to control metabolic processes and maintain proper cell growth.

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Amino Acid Signaling

We study the molecular mechanisms by which the mammalian target of rapamycin complex 1 (mTORC1) senses amino acids, particularly glutamine.

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Human Disease

Our goal is to understand how nutrient sensing by cells is dysregulated in cancer, metabolic disorders, and other human diseases.