Ultrastructure of the nuclear lamins in the lamina and nucleoplasm


The nuclear lamins - Type V intermediate filaments - regulate nuclear shape and mechanical properties, and are important for chromatin organization. They are primarily found in the nuclear lamina adjacent to the inner nuclear membrane but also in the nucleoplasm.

We are collaborating with the Goldman lab at Northwestern University and the Medalia lab at the University of Zurich to study the higher order organization of lamins, and their interactions among each other and with chromatin. This is now possible thanks to recent advances in super-resolution light microscopy and correlative light and electron microscopy, which we are complementing with novel image and data analysis algorithms.