Research

Ultrastructure of the nuclear lamins in the lamina and nucleoplasm

                  LaminsFigure

This is undoubtedly something different, but we got fascinated by nuclear lamins upon a visit by Dr. Robert Goldman to UTSW a few years ago.

The nuclear lamins - Type V intermediate filaments - regulate nuclear shape and mechanical properties, and are important for chromatin organization. They are primarily found in the nuclear lamina adjacent to the inner nuclear membrane but also in the nucleoplasm.

In collaboration with the Goldman lab, we are studying the higher order organization of lamins, and their interactions among each other and with chromatin. This is now possible thanks to recent advances in super-resolution light microscopy and correlative light and electron microscopy, which we are complementing with novel image and data analysis algorithms.