During cell division, chromosomes are aligned and segregated to the two daughter cells via the mitotic spindle. Spindle microtubules that attach to chromosomes at their kinetochores, so-called k-fibers, play a major role in aligning and moving chromosomes.
In most cells, each k-fiber consists of multiple microtubules. In this collaborative project with the Welburn lab at the University of Edinburgh, our goal is to determine how the dynamics of individual microtubules in a k-fiber are regulated and coordinated to generate chromosome movement.
We hope that we will be able to address this question through cutting-edge quantitative live-cell imaging and innovative time series analysis methods.