Linking microtubule dynamics to chromosome movement

Linking microtubule dynamics to chromosome movement

During cell division, chromosomes are aligned and segregated to the two daughter cells via the mitotic spindle. Spindle microtubules that attach to chromosomes at their kinetochores, so-called k-fibers, play a major role in aligning and moving chromosomes.

In most cells, each k-fiber consists of multiple microtubules. In this collaborative project with the Welburn lab at the University of Edinburgh, our goal is to determine how the dynamics of individual microtubules in a k-fiber are regulated and coordinated to generate chromosome movement. 

We hope that we will be able to address this question through cutting-edge quantitative live-cell imaging and innovative time series analysis methods.