Integrin single-molecule dynamics vs. cell edge protrusion activity

Integrin single-molecule dynamics vs. cell edge protrusion activity

Integrins are the key receptors in cell-matrix adhesions and play a critical role in cell migration.

While recent advances in high-resolution microscopy have made it possible to follow the dynamics of single molecules, establishing the relationship between molecular behaviors and cell-level outputs remains a major challenge.

To address this challenge, in collaboration with Catherine and James Galbraith at the NIH, we are developing an integrated imaging, image analysis, and data analysis framework that bridges the gap between the spatial and temporal scales of single-molecule and cell-level event dynamics. This will hopefully allow us to explicitly link integrin single-molecule dynamics to cell edge protrusion activity.