VEGF and Thrombospondin-1 signaling cross-talk

VEGF and Thromsbospondin-1 signaling and cross-talk

VEGF and thrombospondin-1 (TSP-1) are key factors regulating angiogenesis. Each has multiple receptors from different families which in turn interact with each other. TSP-1's mechanism of action is particularly highly debated.

We are investigating the dynamics and cross-interactions between their multiple receptors in order to shed light on the mechanisms of VEGF and TSP-1 signaling and cross-talk. We are interested in questions such as:

  • Do these receptors work separately or together?
  • How do they support or antagonize each other?
  • Are they needed simultaneously or separately under different conditions?