Fractional anisotropy (FA) mapping
Fractional anisotropy (FA) mapping of the cortical surface of fetal brains at the gestational ages shown. Color bar indicates the FA values in the cortical surface FA maps

Project 1

Anatomical Development of Human Fetal Brain with high resolution diffusion tensor imaging

Delineating the anatomical changes of human fetal brain is essential to understand the complicated yet highly organized process of brain development. As complex as the human brain is, its origin is a simple tubular structure. Diffusion tensor imaging (DTI) is noninvasive, three-dimensional and requires relatively less imaging time to characterize the entire brain anatomy with the modern scanners. Digital character of DTI data makes it easily distributed and used as the anatomical reference for developmental study in both basic neuroscience and clinical diagnosis.

Hence, the comprehensive digital 2D/3D qualitative and quantitative structural information from DTI/MRI fills a gap in our knowledge on developmental human brains. It provides anatomical details not only on the macrostructural morphology, but also microstructural organization of the developing cerebral cortex and white matter.

For details, please see our Publications (Huang et al., Neuroimage 2006; Huang et al., Journal of Neuroscience 2009; Huang et al., Cerebral Cortex 2013) on developmental human brains.

We are the consortium member of BrainSpan project (