Research Interests

  • Ion channel physiology, biophysics, and signaling mechanisms of ion channel regulation
  • Human (genetic) diseases caused by ion channel disorders
  • Biology of the WNK kinase cascade and the anti-aging protein Klotho


He, G., Wang, H.-R., Huang, S.-K., and Huang, C.-L. Intersectin links WNK kinases to endocytosis of ROMK. J. Clin. Invest. 117: 1078-1087, 2007.

Cha, S.-K., Ortega, B., Kurosu, H., Rosenblatt K. P., Kuro-o, M, and Huang, C.-L.Removal of sialic acid involving Klotho causes cell-surface retention of TRPV5 channel via binding to galectin-1. Proc. Natl. Acad. Sci USA 105: 9805-9810, 2008.

Liu, Z., Wang, H-R., and Huang, C.-L.(2009) Regulation of ROMK channel and K homeostasis by kidney-specific WNK1 kinase. J. Biol. Chem. 284: 12198-12206, 2009.

Xie, J., Wu, T., Xu, K., Huang, I. K., Cleaver, D., and Huang, C.-L. Endothelial expression of WNK1 is essential for angiogenesis and cardiovascular development in mice. Am. J. Pathology 175: 1315-1327, 2009.

Liu, Z., Xie, J., Wu, T., Thao, T., Auchus, R. J., and Huang, C.-L. Downregulation of NCC and NKCC2 cotransporters by kidney-specific WNK1 revealed by gene disruption and transgenic mouse models. Hum. Mol. Genet. 20: 855-866, 2011.

Huang C.-L., Slesinger, P.A., Casey, P.J., Jan, Y.N. and Jan, L.Y. Evidence that direct binding of G protein Βγ subunit to the GIRK1 G protein gated-inwardly rectifying K channel is important for channel activation. Neuron 15: 1133-1143, 1995.

Huang, C.-L., Feng, S. and Hilgemann, D.W. Direct activation of inward rectifier potassium channels by PIP2 and its stabilization by GΒγ. Nature 391: 803-806, 1998.

Liou, H.-H., Zhou, S.S., and Huang C.-L. Regulation of ROMK1 channel by protein kinase A via a phosphatidylinositol 4,5-bisphosphate-dependent mechanism. Proc. Natl. Acad. Sci. USA 96: 5820-5825, 1999.

Yeh, B.-I., Kim, Y. K., Jabbar, W., and Huang, C.-L. Conformational changes of pore helix coupled to gating of TRPV5 by protons. EMBO J. 24: 3224-3234, 2005.

Lazrak, A., Liu, Z., and Huang, C.-L. Antagonistic regulation of ROMK by long and kidney-specific WNK1 isoforms. Proc. Natl. Acad. Sci. USA 103: 1615-1620, 2006.