Publications

Publications for Dr. Ming Hu

Original Research Articles

Mizuno M, Mitchell JH, Crawford S, Huang CL, Maalouf NM, Hu MC, Moe OW, Smith SA, Vongpatanasin W. High Dietary Phosphate Intake Induces Hypertension and Augments Exercise Pressor Reflex Function in Rats. Am J Physiol Regul Integr Comp Physiol. 2016 May 11:ajpregu.00124.2016. doi: 10.1152/ajpregu.00124.2016. [Epub ahead of print]

Neyra JA, Hu MC. αKlotho and Chronic Kidney Disease. Vitam Horm. 2016;101:257-310. doi: 10.1016/bs.vh.2016.02.007. Epub 2016 Mar 24.

Hu MC. Klotho connects intermedin1-53 to suppression of vascular calcification in chronic kidney disease. Kidney Int. 2016 Mar;89(3):534-7. doi: 10.1016/j.kint.2015.12.036.

Ravikumar P, Li L, Ye J, Shi M, Taniguchi M, Zhang J, Kuro-O M, Hu MC, Moe OW, Hsia CC. αKlotho deficiency in acute kidney injury contributes to lung damage. J Appl Physiol (1985). 2016 Apr 1;120(7):723-32. doi: 10.1152/japplphysiol.00792.2015. Epub 2015 Dec 30.

Shi M, Flores B, Gillings N, Bian A, Cho HJ, Yan S, Liu Y, Levine B, Moe OW, Hu MC. αKlotho Mitigates Progression of AKI to CKD through Activation of Autophagy. J Am Soc Nephrol. 2015 Dec 23. pii: ASN.2015060613. [Epub ahead of print]

Bian A, Neyra JA, Zhan M, Hu MC. Klotho, stem cells, and aging. Clin Interv Aging. 2015 Aug 4;10:1233-43. doi: 10.2147/CIA.S84978. eCollection 2015. Review.

Hu MC, Shi M, Zhang J, Addo T, Cho HJ, Barker SL, Ravikumar P, Gillings N, Bian A, Sidhu SS, Kuro-o M, Moe OW. Renal Production, Uptake, and Handling of Circulating αKlotho. J Am Soc Nephrol. 2016 Jan;27(1):79-90. doi: 10.1681/ASN.2014101030. Epub 2015 May 14.

Neyra JA, Moe OW, Hu MC. Fibroblast growth factor 23 and acute kidney injury. Pediatr Nephrol. 2015 Nov;30(11):1909-18. doi: 10.1007/s00467-014-3006-1. Epub 2014 Dec 6.

Hu MC, Shi M, Cho HJ, Adams-Huet B, Paek J, Hill K, Shelton J, Amaral AP, Faul C, Taniguchi M, Wolf M, Brand M, Takahashi M, Kuro-O M, Hill JA, Moe OW. Klotho and phosphate are modulators of pathologic uremic cardiac remodeling. J Am Soc Nephrol. 2015 Jun;26(6):1290-302. doi: 10.1681/ASN.2014050465. Epub 2014 Oct 17.

Barker SL, Pastor J, Carranza D, Quiñones H, Griffith C, Goetz R, Mohammadi M, Ye J, Zhang J, Hu MC, Kuro-o M, Moe OW, Sidhu SS. The demonstration of αKlotho deficiency in human chronic kidney disease with a novel synthetic antibody.Nephrol Dial Transplant. 2015 Feb;30(2):223-33. doi: 10.1093/ndt/gfu291. Epub 2014 Oct 15.

Hu MC, Shi M, Zhang J, Addo T, Cho HJ, Barker SL, Ravikumar P, Gillings N, Bian A, Sidhu SS, Kuro-O M, Moe OW. Renal Production, Uptake, and Handling of Circulating αKlotho. J Am Soc Nephrol. 2015 May 14.

Neyra JA, Moe OW, Hu MC. Fibroblast growth factor 23 and acute kidney injury. Pediatr Nephrol. 2014 Dec 6

Hu MC, Shi M, Cho HJ, Adams-Huet B, Paek J, Hill K, Shelton J, Amaral AP, Faul C, Taniguchi M, Wolf M, Brand M, Takahashi M, Kuro-O M, Hill JA, Moe OW. Klotho and Phosphate Are Modulators of Pathologic Uremic Cardiac Remodeling. J Am Soc Nephrol. 2014 Oct 17.

Barker SL, Pastor J, Carranza D, Quinones H, Griffith C, Goetz R, Mohammadi M, Hu MC, Kuro-O M, Moe OW, Sidhu SS. The demonstration of αKlotho deficiency in human chronic kidney disease with a novel synthetic antibody. Nephrol Dial Transplant. 2014 Oct 15.

Bian A, Xing C, Hu MC. Alpha Klotho and phosphate homeostasis. J Endocrinol Invest. 2014 Sep 7.

Ravikumar P, Ye J, Zhang J, Pinch SN, Hu MC, Kuro-O M, Hsia CC, Moe OW. α-Klotho protects against oxidative damage in pulmonary epithelia. Am J Physiol Lung Cell Mol Physiol. 2014 Oct 1; 307(7):C566-75.

Lindberg K, Amin R, Moe OW, Hu MC, Erben RG, Ostman Wernerson A, Lanske B, Olauson H, Larsson TE. The Kidney Is the Principle Organ Mediating Klotho Effects. J Am Soc Nephrol. 2014 May 22.

Panesso MC, Shi M, Cho HJ, Paek J, Ye J, Moe OW, Hu MC. Klotho has dual protective effects on cisplatin-induced acute kidney injury. Kidney Int. 2014 Apr; 85(4): 8555-70

Hu MC, Shi M, Cho HJ, Zhang J, Pavlenco A, Liu S, Sidhu S, Huang LJ, Moe OW. The erythropoietin receptor is a downstream effector of Klotho-induced cytoprotection. Kidney Int. 2013; 84(3):468-81

Hu MC, Di Sole F, Zhang J, McLeroy P, Moe OW. Chronic regulation of the renal Na(+)/H(+) exchanger NHE3 by dopamine: translational and posttranslational mechanisms. Am J Physiol Renal Physiol. 2013; 304:F1169-1180.

Rutkowski JM, Wang ZV, Park AS, Zhang J, Zhang D, Hu MC, Moe OW, Susztak K, Scherer PE. Adiponectin promotes functional recovery after podocyte ablation. J Am Soc Nephrol. 2013;24:268-282.

Lau WL, Leaf EM, Hu MC, Takeno MM, Kuro-o M, Moe OW, Giachelli CM. Vitamin D receptor agonists increase klotho and osteopontin and decrease aortic calcification in mice with chronic kidney disease fed a high phosphate diet. Kidney Int, 2012; 82:1261-1270

Faul C, Amaral AP, Oskouei B, Hu MC, Sloan A, Isakova T, Gutiérrez OM, Aguillon-Prada R, Lincoln J, Hare JM, Mundel P, Morales A, Scialla J, Fischer M, Soliman EZ, Chen J, Go AS, Rosas SE, Nessel L, Townsend RR, Feldman HI, St John Sutton M, Ojo A, Gadegbeku C, Di Marco GS, Reuter S, Kentrup D, Tiemann K, Brand M, Hill JA, Moe OW, Kuro-O M, Kusek JW, Keane MG, Wolf M. FGF23 induces left ventricular hypertrophy. J Clin Invest, 2011; 121:4393-4408

Di Sole F, Hu MC, Zhang J, McLeroy P, Thomas E. Rogers TE, Moe OW. Ischemia-Reperfusion Injury Decreases Renal Na/H Exchanger NHE3 Expression by Destabilization of NHE3 Protein. Kidney Int, 2011; 80:822-831

Hu MC, Shi M, Zhang J, Griffith C, Quiñones H, Kuro-O M, Moe OW. Klotho deficiency causes vascular calcification in chronic kidney disease. JASN, 2011; 22:124-136 Hu MC, Shi M, Zhang J, Quiñones H, Kuro-O M, Moe OW. Klotho deficiency is an early biomarker of renal ischemia-reperfusion injury and its replacement is protective. Kidney Int, 2010; 78:1240-1251

Hu MC, Shi M, Zhang J, Pastor J, Nakatani T, Lanske B, Shawkat Razzaque M, Rosenblatt KP, Baum MG, Kuro-O M, Moe OW. Klotho: a novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule. FASEB J, 2010; 24:2438-2450

Bobulescu IA, Quiñones H, Gisler SM, Di Sole F, Hu MC, Shi M, Zhang J, Fuster DG, Wright N, Mumby M, Moe OW. Acute Regulation of Renal Na+/H+ Exchanger NHE3 by Dopamine: Role of Protein Phosphatase 2A. Am J Physiol Renal Physiol, 2010; 298:F1205-1213.

Goetz R, Nakadab Y, Hu MC, Kurosu H, Wang L, Nakatani T, Shi M, Eliseenkova AV, Razzaque MS, Moe OW, Kuro-o M, Mohammadi M. Isolated C-terminal tail of FGF23 alleviates hypophosphatemia by inhibiting FGF23-FGFR-Klotho complex formation. PNAS, 2010, 107:407-12.

Cha CK, Hu MC, Kurosu H, Kuro-o M, Moe OW, Huang CH. Regulation of ROMK1 channel ad renal K+ excretion by Klotho. Mol Pharmacol, 2009, 76:38-46

Sas D, Hu MC, Moe OW, Baum M. Effect of claudins 6 and 9 on paracellular permeability in MDCK II cells. Am J Physiol Regul Integr Comp Physiol, 2008; 295:R1713-1719.

Kurosu H, Ogawa Y, Miyoshi M, Yamamoto M, Nandi A, Rosenblatt KP, Baum MG, Susan Schiavi, Hu MC, Moe OW, Kuro-o M. Regulation of fibroblast growth factor-23 signaling by klotho. J Biol Chem, 2006; 281:6120-6123

Hu MC, Mo R, Bhella S, Chung PT, Hui CC, Rosenblum ND. GLI3-dependent transcriptional repression of GLI1 and GLI2 and kidney patterning genes disrupts renal morphogenesis. Development, 2006; 133:569-578

Mill P, Mo R, Hu MC, Dagnino L, Rosenblum ND, Hui CC. Shh Controls Epithelial Proliferation via Independent Pathways that Converge on N-Myc. Dev Cell, 2005; 9:293-303

Hu MC, Rosenblum ND. Smad1, beta-catenin and Tcf4 associate in a molecular complex with the Myc promoter in dysplastic renal tissue and cooperate to control Myc transcription. Development, 2005;132:215-225

Hartwig S, Hu MC, Cella C, Piscione T, Filmus J, Rosenblum ND. Glypican-3 modulates inhibitory Bmp2-Smad signaling to control renal development in vivo. Mech Dev, 2005, 122:928-938

Leung-Hagesteijn C, Hu MC, Mahendra AS, Hartwig S, Klamut HJ, Rosenblum ND, Hannigan GE. Integrin-linked kinase mediates bone morphogenetic protein 7-dependent renal epithelial cell morphogenesis. Mol Cell Biol, 2005, 25:3648-3657

Hu MC, Wasserman D, Hartwig S, Rosenblum ND. p38MAPK acts in the BMP7-dependent stimulatory pathway during epithelial cell morphogenesis and is regulated by Smad1. J Biol Chem, 2004; 279:12051-12059.

Hu MC, Piscione TD, Rosenblum ND. Elevated SMAD1/beta-catenin molecular complexes and renal medullary cystic dysplasia in ALK3 transgenic mice. Development, 2003; 130:2753-2766.

Klisic J, Hu MC, Nief V, Reyes L, Fuster D, Moe OW, Ambühl PM. Insulin activates Na(+)/H(+) exchanger 3: biphasic response and glucocorticoid dependence. Am J Physiol Renal Physiol. 2002; 283:F532-F539.

Hu MC, Fan L, Crowder LA, Karim-Jimenez Z, Murer H, Moe OW. Dopamine acutely stimulates Na-H exchanger (NHE3) endocytosis via clathrin-coated vesicles: dependence on protein kinase-A mediated NHE3 phosphorylation. J Biol Chem, 2001; 276:26906-36915.

Collazo R, Fan L, Hu MC, Zhao H, Wiederkehr MR, Moe OW. Acute regulation of Na+/H+ exchanger NHE3 by parathyroid hormone via NHE3 phosphorylation and dynamin-dependent endocytosis. J Biol Chem. 2000; 275:31601-31608.

Hu MC, Bankir L, Michelet S, Rousselet G, Trinh-Trang-Tan MM. Massive reduction of urea transporters in remnant kidney and brain of uremic rat. Kidney Int, 2000; 58:1202-1010.

Hu MC, Bankir L, Trinh-Trang-Tan MM. mRNA expression of renal urea transporters in normal and Brattleboro rats: effect of dietary protein intake. Exp Nephrol, 1999; 7:44-51.

Promeneur D, Bankir L, Hu MC, Trinh-Trang-Tan MM. Renal tubular and vascular urea transporters: influence of antidiuretic hormone on messenger RNA expression in Brattleboro rats. J Am Soc Nephrol. 1998; 9:1359-1366.

Latremouille C, Genevaz D, Hu MC, Schussler O, Goussef N, Mandet C, Bruneval P, Haeffner-Cavaillon N, Carpentier A, Glotz D. Normal human immunoglobulins for intravenous use (IVIg) delay hyperacute xenograft rejection through F(ab')2-mediated anti-complement activity. Clin Exp Immunol. 1997; 110:122-126.

Reviews, Chapters, Monographs, and Editorials

Hu MC, Kuro-O M, Moe OW. αKlotho and vascular calcification: an evolving paradigm. Curr Opin Nephrol Hypertens. 2014; Jul 23(4):331-9.doi:10.1097/01

Hu MC, Kuro-o M, Moe OW. Klotho and chronic kidney disease. Contrib Nephrol. 2013; 180:47-63.

Hu MC, Kuro-o M, Moe OW. Renal and extrarenal actions of Klotho. Semin Nephrol. 2013; 33:118-129.

Hu MC, Shiizaki K, Kuro-o M, Moe OW. Fibroblast growth factor 23 and Klotho: physiology and pathophysiology of an endocrine network of mineral metabolism. Annu Rev Physiol. 2013; 75:503-533.

Hu MC, Kuro-O M, Moe OW. The emerging role of Klotho in clinical nephrology. Nephrol Dial Transplant, 2012; 27:2650-7.

Hu MC, Moe OW. Klotho as a potential biomarker and therapy for acute kidney injury. Nat Rev Nephrol, 2012; 8:423-429.

Hu MC, Kuro-o M, Moe OW. Secreted Klotho and chronic kidney disease. Adv Exp Med Biol, 2012; 728:126-157.

Hu MC, Kuro-o M, Moe OW. Klotho and kidney disease. J Nephrol, 2010; 16:S136-S144

Hu MC, Rosenblum ND. Genetic regulation of branching morphogenesis: lessons learned from loss-of-function phenotypes. Pediatr Res, 2003; 54:433-438.