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Renal Insults

WT mice develop CKD in 20 weeks after bilateral ischemia reperfusion injury (Bi-IRI), uninephrectomy and contralateral ischemia reperfusion injury (Npx-IRI) or a single injection with cisplatin (CPIN).

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Klotho

Klotho deficiency up-regulates TSP-1 and leads to vessel rarefaction in the kidney; Klotho overexpression reverses the effect.

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Phosphate

A high-phosphate diet induces severe cardiac remodeling in Klotho deficiency in kl/+ mice, and mild changes in Tg-Kl mice, compared to WT mice.

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Immunohistochemistry

P-Erk (green), collagen I (blue), and Alexa-Fluor–WGA (red) in left ventricular sections of kl/+, WT, and Tg-Kl mice, 15 months old, fed with high-phosphate diet.