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Research

Calcium Signaling

Calcium signaling diagram
Calcium signaling diagram

It is widely agreed that derangements in intracellular Ca2+ homeostasis are proximal events in many types of heart disease. Further, some evidence implicates abnormal Ca2+ handling in the pathogenesis of disease progression, possibly participating in a vicious cycle with transcription and other processes. Using biophysical, electrophysiological, and molecular methods, work is underway to explore this process as a potential target for therapeutic intervention.