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Research

Cardiomyocyte Autophagy

Cardiomyocyte Autophagy diagram

We, and others, have hypothesized that cardiomyocyte death contributes to the transition from stable hypertrophy to heart failure. We have collected recent evidence implicating autophagy, a highly conserved pathway for recycling intracellular proteins and organelles, in the pressure-stressed heart. In other contexts, autophagy is capable of inducing a caspase-independent form of programmed cell death. Work is underway to elucidate molecular mechanisms of autophagy in heart and to explore its contribution to the pathogenesis of heart failure.