Research

Research

Our research program is focused on many aspects of cell biology of different bacterial species that are often causes of infectious diseases in humans and other hosts. The foundations of our research program began with analyzing colonization and virulence determinants of Campylobacter jejuni required for host infection and understanding how transcription of C. jejuni genes required for flagellar motility are regulated.

While these projects remain major emphases of our research program, we have expanded our focus over time. Currently, we have many active research projects that are providing insights into a wide range of interesting aspects of microbial cell biology. These areas include:

  • Understanding signal transduction pathways common to bacterial pathogens
  • Analyzing how polar flagellar motors are spatially and numerically regulated in many polarly-flagellated pathogens
  • Identifying unique structural elements of polar flagellar motors
  • Determining in vivo stimuli sensed by bacterial pathogens
  • Monitoring communication between macromolecular complexes in the bacterial cell
  • Determining new mechanisms for spatial regulation of bacterial division
  • Identifying new virulence determinants of bacterial pathogens
  • Analyzing broad aspects of the biology of polar flagellates