Adi F. Gazdar, M.D.
Education: M.D. – Guy's Hospital Medical School, England
Research Interests – To determine molecular and genetic basis of human cancers, and to develop molecular insights to provide prognostic and diagnostic therapies in the treatment of human cancers.
Xiao-Yun Liu, Ph.D.
Education: Ph.D., pharmacology – Chinese Accademy of Medical Sciences, Beijing
Research Interests – Protein synthesis is the key to support cell growth and division. Translational elongation factors are a set of proteins that accurately bind and deliver aminoacyl-tRNA to the ribosome, thereby extending the first peptide bond to the last one. Some elongation factors are uniformly expressed in both tumor and non-malignant tissues, while others are differentially expressed and may be important cancer biomarkers.
My current project is to dissect the significance of differential expression of elongation factors in carcinogenesis with the long-term goal to pursue their diagnostic and therapeutic potential for cancer.
Wei Zhang, Ph.D.
Education: Ph.D., molecular biology
Research Interests – My current project in Dr. Gazdar’s lab is to study the inactivation mechanisms of chromatin remodeling SWI/SNF complex in lung cancers and its downstream effects.
Yu-An Zhang, Ph.D., M.D.
Education: M.D. – Henan Medical University, China; Ph.D. – biomedical studies (molecular cancer gene therapy), Baylor University
Research Interests – The epigenetic dysregulation in chromatin remodeling and histone modification process have been recently demonstrated to be involved in varied types of cancer although the scope and role of the genes involved are yet to be studied.
In Dr. Gazdar’s lab, my research is to investigate whether the gene(s) in chromatin remodeling SWI/SNF complex and histone methyltransferase genes are dysregulated in lung cancer. Our studies have potential to advance our understanding of lung cancer and indentify new biomarkers/targets clinically relevant.
Education: B.S. – Fort Lewis College, Colorado
Research Interests – I am a Dallas native. My current projects involve culturing a variety of human tissues and creating sets of paired tumor and non-malignant cell lines for use as cancer models.
Research Associate, Co-Lab Manager
Education: B.S. – microbiology, Azad University, Iran
Research Interests – My main research focus in the lab is on establishing ovarian cancer cell lines from malignant ascites.
Kuntal Majmudar, M.D.
Research Interests – Since joining the lab in 2011, I have assisted in updating and maintaining the Lung SPORE publications' database that is shared between UT Southwestern and M.D. Anderson Cancer Center researchers. I also obtain PMCID numbers for NIH-funded publications for principal investigators at the Hamon Center.
Yi-Wei Wang, Ph.D.
Education: Ph.D. – National Defense Medical Center, Taiwan
Research Interests – I joined Dr. Gazdar’s lab in September 2012. My current research focuses on novel oncogenes in lung cancer, and their potential therapeutic applications.
Yibing Yao, Ph.D., M.D.
Visiting Junior Researcher
Education: Ph.D., M.D. – oncology, Tianjin Medical University, China
Research Interests – My research is to study deregulation of the SWI/SNF chromatin remodeling complex in lung cancer tumors and cell lines – with the emphasis on some selected genes – and find mechanisms for widespread inactivation of these genes.