Research

Research

Lipodystophy

Lipodystrophy study at UT Southwestern Medical Center is dedicated to the study, research, and therapy of human adipose tissue disorders. These pages provide an overview of the research efforts, as well as information about the research team, therapies, enrolling in patient studies, and additional resources.

Lipodystrophies are disorders of adipose tissue (fat) characterized by selective loss of fat from various parts of the body. There are several different types of lipodystrophies and the degree of fat loss may vary from very small depressed areas to near complete absence of adipose tissue.

The extent of fat loss may determine the severity of metabolic complications related to insulin resistance, such as diabetes mellitus and high levels of serum triglycerides. Some patients may have only cosmetic problems while others may also have severe metabolic complications. These disorders can either be inherited (familial or genetic) lipodystrophies or can be secondary to various types of illnesses or drugs (acquired lipodystrophies).

Diabetes

Dr. Garg's research has focused on the problems of diabetes, insulin resistance, and disorders of adipose tissue. During his early years in the Center for Human Nutrition, he completed significant studies on dietary therapy of patients with diabetes and drug therapy of lipid disorders in patients with adult-onset (Type 2) diabetes. His careful studies at the General Clinical Research Center at UT Southwestern showed that diabetes and its metabolic complications are better controlled with diets high in monounsaturated fatty acids than on low-fat, high-carbohydrate diets. His first major publication, which was carried out entirely at UT Southwestern, had a major impact on health professionals who care for patients with diabetes.