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The genome of living organisms is subject to a wide variety of damages caused spontaneously or by exposure to environmental agents, which interact with DNA. If unrepaired, DNA damage can result in permanent alterations in nucleotide sequence, thereby generating mutations. The potential phenotypic consequences of mutations in somatic cells include neoplastic transformation. My laboratory is interested in understanding the molecular mechanisms by which cells repair and tolerate DNA damage and thereby mitigate against the phenotypic consequences of mutational alterations.