Project 1: Auditory Circuit Studies

Project 1: Molecular and Synaptic Mechanisms of Auditory Circuit Dysfunction in FXS Mice

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Kimberly Huber, Ph.D. and Jay Gibson, Ph.D. at UT Southwestern will study the molecular and synapticmechanisms underlying cortical circuit hyperexcitability in auditory cortex (A1) of the Fmr1 knockout(KO) mouse.

The role of specific neurotransmitter receptors, ion channels and cellular signaling pathways will be tested for their contribution to hyperexcitability and the role of distinct synaptic circuits will be examined. Targeting these mechanisms, the researchers will test pharmacological and genetic strategies to correct hyperexcitability. 

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