Research

Research

  • Functional Neurocircuitry of Body Weight Control

    This research program focuses primarily, but not exclusively, on using Cre/lox technology to perturb specific genes in narrow subsets of neurons. The effort is using state-of-the-art BAC genomic clone methodologies to transgenically drive expression of Cre to subsets of neurons. 

  • Interactions of Serotonin and Melanocortin Pathways

    This research investigated the mechanisms through which central serotonergic (5-hydroxytryptamine, 5-HT) systems recruit leptin-responsive hypothalamic pathways, such as the melanocortin systems, to affect energy balance.

  • Leptin Activated Pathways

    This research investigated the central circuits through which leptin acts. The lab systematically examined distributions of mRNA of leptin receptors in the rat brain by using a probe specific for the long form and a probe recognizing all known forms of the leptin receptor.

  • Neuroanatomic Basis of Ghrelin Action

    This research uses neuroanatomical approaches, including in situ hybridization histochemistry (ISHH), to examine more closely the central expression patterns of the ghrelin receptor, paying special attention to its expression in the brainstem. 

  • Neuroanatomic Basis of Melanocortin Action

    This research hopes to identify critical sites expressing MC4-Rs in the CNS that underlie the anti-obesity properties of MC4-R agonists. 

  • Role of Central GLP1 in Autonomic Control

    This research explores new therapies that safely and effectively lower blood glucose in diabetic subjects.

Liver trichrome stain
Duodenum
Adrenal gland
Lung