In the era of "big data," we are faced with the next big question in life science: How do we go from a large ‘hairball’ network to biological function and understanding?
This question is especially pertinent to cancer signaling, where malfunctions in complex networks governed by unknown principles interact in time and space to promote uncontrolled proliferation.
Despite its importance, this question has been hard to approach using conventional techniques. However, we now possess tools to observe these decisions as they happen with high precision using single-cell techniques.
We expect to uncover many exciting new mechanisms governing cell-fate decisions.