Two papers describing the identification of cGAMP (cyclic-GMP-AMP) and cGAS (cyclic-GMP-AMP synthase) as important cytosolic DNA sensing mediators are published today by Science.
Cyclic-GMP-AMP Is An Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA.
Cyclic GMP-AMP Synthase is a Cytosolic DNA Sensor that Activates the Type-I Interferon Pathway.
Congratulations to Josh, Jiaxi, Fenghe, Xiang and James!