Publications for Richard Bruick, Ph.D.

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Featured Publications

Regulation of HIF by prolyl hydroxylases: recruitment of the candidate tumor suppressor protein ING4.

Ozer A, Bruick RK Cell Cycle 2005 Sep 4 9 1153-6

Saururus cernuus lignans--potent small molecule inhibitors of hypoxia-inducible factor-1.

Hossain CF, Kim YP, Baerson SR, Zhang L, Bruick RK, Mohammed KA, Agarwal AK, Nagle DG, Zhou YD Biochem. Biophys. Res. Commun. 2005 Aug 333 3 1026-33

The candidate tumor suppressor ING4 represses activation of the hypoxia inducible factor (HIF).

Ozer A, Wu LC, Bruick RK Proc. Natl. Acad. Sci. U.S.A. 2005 May 102 21 7481-6

Laurenditerpenol, a new diterpene from the tropical marine alga Laurenciaintricata that potently inhibits HIF-1 mediated hypoxic signaling in breast tumor cells.

Mohammed KA, Hossain CF, Zhang L, Bruick RK, Zhou YD, Nagle DG J. Nat. Prod. 2004 Dec 67 12 2002-7

Depletion of intracellular ascorbate by the carcinogenic metals nickel and cobalt results in the induction of hypoxic stress.

Salnikow K, Donald SP, Bruick RK, Zhitkovich A, Phang JM, Kasprzak KS J. Biol. Chem. 2004 Sep 279 39 40337-44

Identification and characterization of a novel RNA binding protein that associates with the 5'-untranslated region of the chloroplast psbA mRNA.

Barnes D, Cohen A, Bruick RK, Kantardjieff K, Fowler S, Efuet E, Mayfield SP Biochemistry 2004 Jul 43 26 8541-50

Deficiency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysis.

Iizuka K, Bruick RK, Liang G, Horton JD, Uyeda K Proc. Natl. Acad. Sci. U.S.A. 2004 May 101 19 7281-6

Proceedings of the Oxygen Homeostasis/Hypoxia Meeting.

Kaufman B, Scharf O, Arbeit J, Ashcroft M, Brown JM, Bruick RK, Chapman JD, Evans SM, Giaccia AJ, Harris AL, Huang E, Johnson R, Kaelin W, Koch CJ, Maxwell P, Mitchell J, Neckers L, Powis G, Rajendran J, Semenza GL, Simons J, Storkebaum E, Welch MJ, Whitelaw M, Melillo G, Ivy SP Cancer Res. 2004 May 64 9 3350-6

Structural basis for PAS domain heterodimerization in the basic helix--loop--helix-PAS transcription factor hypoxia-inducible factor.

Erbel PJ, Card PB, Karakuzu O, Bruick RK, Gardner KH Proc. Natl. Acad. Sci. U.S.A. 2003 Dec 100 26 15504-9

Oxygen sensing in the hypoxic response pathway: regulation of the hypoxia-inducible transcription factor.

Bruick RK Genes Dev. 2003 Nov 17 21 2614-23

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