David Boothman, Ph.D.
Professor of Oncology, Pharmacology, and Radiation Oncology
Associate Director for Translational Research, Simmons Comprehensive Cancer Center
The Robert and Virginia Payne Endowed Professor of Oncology
Dr. Boothman grew up in Detroit, Michigan, and earned his B.S. at the University of Michigan-Ann Arbor. He did his graduate work in microbiology and immunology at the University of Miami Medical School, where he received his Ph.D. under the mentorship of Dr. Sheldon Greer. His research focused on the biochemistry and pharmacology of anticancer drugs, specifically 5-fluoro-deoxycytidine derivatives.
He did postdoctoral research at the Dana-Farber Cancer Institute of Harvard Medical School with Dr. Arthur B. Pardee. There, he investigated changes in several aspects of cancer cells before and after cell stress: cell cycle checkpoint regulation, molecular biology, and gene expression. His studies on β-lapachone as a radiosensitizer and DNA repair inhibitor began at this time. Dr. Boothman also discovered and cloned the first proteins and transcripts induced by ionizing radiation (IR).
In 1990, Dr. Boothman became Assistant Professor at the University of Michigan-Ann Arbor and continued his investigations of x-ray-inducible proteins (Boothman et al., Cancer Research, 1988), and x-ray-inducible transcripts leading to proteins (Boothman et al., PNAS, 2000). He discovered xip8 (clusterin) and its induction by super-low levels of IR exposure. Dr. Boothman then joined the faculty in the Department of Human Oncology at the University of Wisconsin-Madison, where he rose to Associate Professor with tenure and became the Vice Chairman of Radiation Oncology, and Division Head of Molecular Radiation Oncology.
In 1998, Dr. Boothman accepted an Endowed Professorship at Case Western Reserve University and became heavily involved in the Cancer Center. In 2000, he became the Associate Director for Basic Science and headed the research effort in the Cancer Center’s Wolstein Research Building.
In 2005, Dr. Boothman and his close colleague Dr. Jinming Gao moved to UT Southwestern Medical Center to start the Cell Stress and Cancer Nanomedicine Program.
Dr. Boothman has trained 16 Ph.D. students, two M.D./Ph.D. students, and more than 40 postdoctoral fellows and residents, who enjoy positions around the nation and in seven different countries and in various aspects of scientific research.
Dr. Boothman’s laboratory is supported by grants from the National Institutes of Health/National Institutes of Cancer, Pancreatic Cancer Action Network/AACR, Department of Defense, Department of Energy and CPRIT. Dr. Boothman has published more than 150 peer-reviewed papers and has had continuous extramural funding for more than 25 years.
The laboratory has also been fortunate to have the continuing support of Dr. and Mrs. Sarah Hildebrand, Ms. Rosemarie Bouley, and Mrs. Frances Boothman.