2013 (5 articles)

• E.M. Moresco, X. Li, B. Beutler. Going forward with genetics: recent technological advances and forward genetics in mice. Am J Pathol 182:1462-73, (2013). PMID:23608223. 
• Y.T. Koh, J.C. Scatizzi, J.D. Gahan, B.R. Lawson, R. Baccala, K.M. Pollard, B.A. Beutler, A.N. Theofilopoulos, D.H. Kono. Role of nucleic acid-sensing TLRs in diverse autoantibody specificities and anti-nuclear antibody-producing B cells. J Immunol Apr 15, (2013). PMID: 23589617.
• C.E. Teh, K. Horikawa, C.N. Arnold, B. Beutler, E.M. Kucharska, C.G. Vinuesa, E.M. Bertram, C.C. Goodnow, A. Enders. Heterozygous mis-sense mutations in Prkcb as a critical determinant of anti-polysaccharide antibody formation. Genes Immun Apr 4, (2013). PMID:23552399.
• K.R. Bull, A.J. Rimmer, O.M. Siggs, L.A. Miosge, C.M. Roots, A. Enders, E.M. Bertram, T.L. Crockford, B. Whittle, P.K. Potter, M.M. Simon, A.M. Mallon, S.D. Brown, B. Beutler, C.C. Goodnow, G. Lunter, R.J. Cornall. Unlocking the bottleneck in forward genetics using whole-genome sequencing and identity by descent to isolate causative mutations. PLoS Genet 9:e1003219, (2013). PMCID: PMC3561070. 
• R. Baccala, R. Gonzalez-Quintial, A.L. Blasius, I. Rimann, K. Ozato, D.H. Kono, B. Beutler, A.N. Theofilopoulous. Essential requirement for IRF8 and SLC15A4 implicates plasmacytoid dendritic cells in the pathogenesis of lupus. Proc Natl Acad Sci USA 110:2940-5, (2013).  PMCID: PMC3581947.

2012 (7 articles)

• O.M. Siggs, J. Cruite, X. Du, S. Rutschmann, E. Masliah, B. Beutler, M. Oldstone. Disruption of copper homeostasis due to a mutation of Atp7a delays the onset of prion disease. Proc Natl Acad Sci USA. 2012 109(34):13733-8. PMID:22869751.
• O.M. Siggs, N. Xiao, Y. Wang, H. Shi, W. Tomisato, X. Li, Y. Xia, B. Beutler. iRhom2 is required for the secretion of mouse TNF alpha. Blood May 1, (2012). PMID: 22550345.
• S. Rutschmann, K. Crozat, X. Li, X. Du, J.C. Hanselman, A.A. Shigeoka, K. Brandl, D.L. Popkin, D.B. McKay, Y. Xia, E.M. Moresco, B. Beutler. Hypopigmentation and maternal-zygotic embryonic lethality caused by a hypomorphic mbtps1 mutation in mice. G3 (Bethesda) 2(4):499-504, (2012). PMCID: PMC3337478.
• E. Narni-Mancinelli, B.N. Jaeger, C. Bernat, A. Fenis, S. Kung, A. De Gassart, S. Mahmood, M. Gut, S.C. Heath, J. Estellé, E. Bertosio, F. Vely, L.N. Gastinel, B. Beutler, B. Malissen, M. Malissen, I.G. Gut, E. Vivier, S. Ugolini. Tuning of natural killer cell reactivity by NKp46 and Helios calibrates T cell responses. Science 335:344-8, (2012). PMID: 22267813.
• K. Brandl, W. Tomisato, B. Beutler. Inflammatory bowel disease and ADAM17 deletion. N Engl J Med 366:190, (2012). PMID: 22236242.
• O.M. Siggs, X. Li, Y. Xia, B. Beutler. ZBTB1 is a determinant of lymphoid development. J Exp Med 209:19-27, (2012). PMID: 22201126.
• S. Won, C. Eidenschenk, C.N. Arnold, O.M. Siggs, L. Sun, K. Brandl, T.M. Mullen, G.R. Nemerow, E.M. Moresco, B. Beutler. Increased susceptibility to DNA virus infection in mice with a GCN2 mutation.J Virol 86:1802-8, (2012). PMID: 22114338.

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2011 (20 articles)

• P. Krebs, W. Fan, Y.H. Chen, K. Tobita, M.R. Downes, M.R. Wood, L. Sun, X. Li, Y. Xia, N. Ding, J.M. Spaeth, E.M. Moresco, T.G. Boyer, C.W. Lo, J. Yen, R.M. Evans, B. Beutler. Lethal mitochondrial cardiomyopathy in a hypomorphic Med30 mouse mutant is ameliorated by ketogenic diet. Proc Natl Acad Sci USA 108:19678-82, (2011). PMID: 22106289.
• E.M. Moresco and B. Beutler. Resisting viral infection: the gene by gene approach. Curr Opin Virol 1(6):513-8, (2011). PMID: 22440911.
• A.L. Blasius, A.E. Dubin, M.J. Petrus, B.K. Lim, A. Narezkina, J.R. Criado, D.N. Wills, Y. Xia, E.M. Moresco, C. Ehlers, K.U. Knowlton, A. Patapoutian, B. Beutler. Hypermorphic mutation of the voltage-gated sodium channel encoding gene Scn10a causes a dramatic stimulus-dependent neurobehavioral phenotype. Proc Natl Acad Sci USA 108:19413-8, (2011). PMID: 22087007.
• A.N. Theofilpoulos, D.H. Kono, B. Beutler, R. Baccala. Intracellular nucleic acid sensors and autoimmunity. J Interferon Cytokine Res 31:867-86, (2011). PMID: 22029446.
• L. Krieg, O. Milstein, P. Krebs, Y. Xia, B. Beutler, X. Du. Mutation of the gastric hydrogen-potassium ATPase alpha subunit causes iron-deficiency anemia in mice. Blood 118:6418-25, (2011). PMID: 21976678.
• E.M. Moresco, D. LaVine, B. Beutler. Prion-like behavior of MAVS in RIG-I signaling. Cell Res 21:1643-5, (2011). PMID: 21931357.
• D.E. Zak, F. Schmitz, E.S. Gold, A.H. Diercks, J.J. Peschon, J.S. Valvo, A. Niemistö, I. Podolsky, S.G. Fallen, R. Suen, T. Stolyar, C.D. Johnson, K.A. Kennedy, M.K. Hamilton, O.M. Siggs, B. Beutler, A. Aderem. Systems analysis identifies an essential role for SHANK-associated RH domain-interacting protein (SHARPIN) in macrophage Toll-like receptor 2 (TLR2) responses. Proc Natl Acad Sci USA 108(28):11536-41, (2011). PMCID: PMC3136315
• I. Eleftherianos, S. Won, S. Chtarbanova, B. Squiban, K. Ocorr, R. Bodmer, B. Beutler, J.A. Hoffmann and J.L. Imler. ATP-sensitive potassium channel (KATP)-dependent regulation of cardiotropic viral infections. Proc Natl Acad Sci USA 108(29):12024-9, (2011). PMCID: PMC3141999
• E.M. Moresco, D. LaVine, Beutler B. Toll-like receptors. Curr. Biol. 21(13):R488-93, (2011).
• C.H. Xia, E. Lu, H. Liu, X. Du, B. Beutler and X. Gong. The Role of VLDLR in Intraretinal Angiogenesis in Mice. IOVS 52(9):6572-9, (2011).
• P. Krebs, K. Crozat, D. Popkin, M.B. Oldstone and B. Beutler. Disruption of MyD88 signaling suppresses hemophagocytic lymphohistiocytosis in mice. Blood, 117:6582-8, (2011).
• O.M. Siggs, B. Schnabl, B. Webb and B. Beutler. X-linked cholestasis in mouse due to mutations of the P4-ATPase ATP11C. Proc Natl Acad Sci USA 108(19):7890-5, (2011). PMCID: PMC3093471
• E.M. Moresco and B. Beutler. Special Delivery: Granulin Brings CpG DNA to Toll-like Receptor 9. Immunity 34:453-5, (2011).
• O.M. Siggs, C.N. Arnold, C. Huber, E. Pirie, Y. Xia, P. Lin, D. Nemazee and B. Beutler. The P4-type ATPase ATP11C is essential for B lymphopoiesis in adult bone marrow. Nat Immunol. 12(5):434-40, (2011). PMCID: PMC3079768
• D.L. Popkin, J.R. Teijaro, B.M. Sullivan, S. Urata, S. Rutschmann, J.C. de la Torre, S. Kunz, B. Beutler and M. Oldstone. Hypomorphic mutation in the site-1 protease mbtps1 endows resistance to persistent viral infection in a cell-specific manner. Cell Host Microbe 9(3):212-22, (2011). PMCID: PMC3058147
• C. Iavarone, K. Ramsauer, A.V. Kubarenko, J.C. Debasitis, I. Leykin, A.N. Weber, O.M. Siggs, B. Beutler, P. Zhang, G. Otten, U. D'Oro, N.M. Valiante, M.L. Mbow and A. Visintin. A Point Mutation in the Amino Terminus of TLR7 Abolishes Signaling without Affecting Ligand Binding. J Immunol. 186(7):4213-22, (2011).
• S. Beutler and B. Beutler. Ernest Beutler: his life and contribution to medical science. Br J Haematol.,152(5):543-50, (2011).
• K. Crozat, C. Eidenschenk, B.N. Jaeger, P. Krebs, S. Guia, B. Beutler, E. Vivier and S. Ugolini. Impact of ß2 integrin deficiency on mouse Natural Killer cell development and function. Blood, 117(10):2874-82, (2011).
• C.N. Arnold, Y. Xia, P. Lin, C. Ross, M. Schwander, N.G. Smart, U. Müller and B.Beutler. Rapid Identification of a Disease Allele in Mouse Through Whole Genome Sequencing and Bulk Segregation Analysis. Genetics,187(3):633-41, (2011). PMCID: PMC3063661
• B. Beutler and C.C. Goodnow. How host defense is encoded in the mammalian genome.Mamm Genome 22(1-2):1-5, (2011).

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2010 (18 articles)

• M. Guma, J. Kashiwakura, B. Crain, Y. Kawakami, B. Beutler, G.S. Firestein, T. Kawakami, M. Karin. Corr M. JNK1 controls mast cell degranulation and IL-1{beta} production in inflammatory arthritis. Proc Natl Acad Sci USA 107(51):22122-7, (2010). PMCID: PMC3009768
• P.C. Ronald and B. Beutler. Plant and animal sensors of conserved microbial signatures. Science 330(6007):1061-4, Review, (2010).
• K. Brandl, L. Sun, C. Neppl, O.M. Siggs, S.M. Le Gall, W. Tomisato, X. Li, X. Du, D.N. Maennel, C.P. Blobel and B. Beutler. MyD88 signaling in nonhematopoietic cells protects mice against induced colitis by regulating specific EGF receptor ligands. Proc Natl Acad Sci USA 107(46):19967-19972, (2010). PMCID: PMC2993336
• A.L. Blasius, C.N. Arnold, P. Georgel, S. Rutschmann, Y. Xia, P. Lin, C. Ross, X. Li, N.G. Smart and B. Beutler. Slc15a4, AP-3, and Hermansky-Pudlak syndrome proteins are required for Toll-like receptor signaling in plasmacytoid dendritic cells. Proc Natl Acad Sci USA 107(46):19973-19978, (2010). PMCID: PMC2993408
• Y. Xia, S. Won, X. Du, P. Lin, C. Ross, D. La Vine, S. Wiltshire, G. Leiva, S.M. Vidal, B. Whittle, C.C. Goodnow, J. Koziol, E.M. Moresco and B. Beutler. Bulk Segregation Mapping of Mutations in Closely Related Strains of Mice. Genetics,186(4):1139-46, (2010). PMCID: PMC2998299
• M.B. Melo, P. Kasperkovitz, A. Cerny, S. Könen-Waisman, E.A. Kurt-Jones, E. Lien, B. Beutler, J.C. Howard, D.T. Golenbock and R.T. Gazzinelli. UNC93B1 Mediates Host Resistance to Infection with Toxoplasma gondii. PLoS Pathog. 6(8). pii: e1001071, (2010). PMCID: PMC2928809
• G. Wingender, P. Krebs, B. Beutler and M. Kronenberg. Antigen-Specific Cytotoxicity by Invariant NKT Cells In Vivo Is CD95/CD178-Dependent and Is Correlated with Antigenic Potency. J Immunol. 185(5):2721-9, (2010).
• Z. Orinska, N. Föger, M. Huber, J. Marschall, F. Mirghomizadeh, X. Du, M. Scheller, P. Rosenstiel, T. Goldmann, A. Bollinger, B.A. Beutler and S. Bulfone-Paus. I787 provides signals for c-Kit receptor internalization and functionality that control mast cell survival and development. Blood Journal, 116(15):2665-75, (2010).
• C. Eidenschenk, K. Crozat, P. Krebs, R. Arens, D. Popkin, C.N. Arnold, A.L. Blasius, C.A. Benedict, E.M. Moresco, Y. Xia and B. Beutler. Flt3 permits survival during infection by rendering dendritic cells competent to activate NK cells. Proc Natl Acad Sci USA 107(21):9759-64, (2010). PMCID: PMC2906899
• A.L. Blasius and B. Beutler. Intracellular toll-like receptors. Immunity 32(3):305-15, (2010).
• M. Berger, P. Krebs, K. Crozat, X. Li, B.A. Croker, O.M. Siggs, D. Popkin, X. Du, B.R. Lawson, A.N. Theofilopoulos, Y. Xia, K. Khovananth, E.M.Y. Moresco, T. Satoh, O. Takeuchi, S. Akira and B. Beutler. An Slfn2 mutation causes lymphoid and myeloid immunodeficiency due to loss of immune cell quiescence. Nat Immunol. 11(4):335-43, (2010). PMCID: PMC2861894
• M.J. Barnes, H. Aksoylar, P. Krebs, T. Bourdeau, C.N. Arnold, Y. Xia, K. Khovananth, I. Engel, S. Sovath, K. Lampe, E. Laws, A. Saunders, G.W. Butcher, M. Kronenberg, K. Steinbrecher, D. Hildeman, H.L. Grimes, B. Beutler and K. Hoebe. Loss of T cell and B cell quiescence precedes the onset of microbial flora-dependent wasting disease and intestinal inflammation in Gimap5-deficient mice. J Immunol. 184(7):3743-54, (2010).
• A.N. Theofilopoulos, R. Gonzalez-Quintial, B.R. Lawson, Y.T. Koh, M.E. Stern, D.H. Kono, B. Beutler and R. Baccala. Sensors of the innate immune system: their link to rheumatic diseases. Nat Rev Rheumatol. 6(3):146-56, (2010).
• E.M. Moresco and B. Beutler. LGP2: positive about viral sensing. Proc Natl Acad Sci USA, 107(4):1261-2, (2010). PMCID: PMC2824419
• O.M. Siggs, M. Berger, P. Krebs, C.N. Arnold, C. Eidenschenk, C. Huber, E. Pirie, N.G. Smart, K. Khovananth, Y. Xia, G. McInerney, G.B. Karlsson Hedestam, D. Nemazee and B. Beutler. A mutation of Ikbkg causes immune deficiency without impairing degradation of I{kappa}B{alpha}. Proc Natl Acad Sci USA, 107(7):3046-51, (2010). PMCID: PMC2840324
• R.A. Fock, S.L. Blatt, B. Beutler, J. Pereira, M. Tsujita, F.E. de Barros and P. Borelli. Study of lymphocyte subpopulations in bone marrow in a model of protein-energy malnutrition. Nutrition. 26(10)1021-8, (2010).
• O. Osborn, M. Sanchez-Alavez, S.E. Brownell, B. Ross, J. Klaus, J. Dubins, B. Beutler, B. Conti and T. Bartfai. Metabolic Characterization of a Mouse Deficient in All Known Leptin Receptor Isoforms. Cell Mol Neurobiol. 30(1):23-33, (2010). PMCID: PMC2813927
• H. Liu, M. Wang, C.H. Xia, X. Du, J.G. Flannery, K.D. Ridge, B. Beutler and X. Gong. Severe retinal degeneration caused by a novel rhodopsin mutation. Investigative Ophthalmology & Visual Science 51(2):1059-65, (2010). PMCID: PMC2868463

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2009 (18 articles)

• N. Xiao, C. Eidenschenk, P. Krebs, K. Brandl, A.L. Blasius, Y. Xia, K. Khovananth, N.G. Smart and B. Beutler. The Tpl2 mutation sluggish impairs type I IFN production and increases susceptibility to group B streptococcal disease. J Immunol. 183(12):7975-83,(2009).
• M.J. Jimenez-Dalmaroni, N. Xiao, A.L. Corper, P. Verdino, G.D. Ainge, D.S. Larsen, G.F. Painter, P.M. Rudd, R.A. Dwek, K. Hoebe, B. Beutler and I.A. Wilson. Soluble CD36 ectodomain binds negatively charged diacylglycerol ligands and acts as a co-receptor for TLR2, PLoS One 4(10):e7411, (2009). PMCID: PMC2760212
• E. Slack, S. Hapfelmeier, B. Stecher, Y. Velykoredko, M. Stoel, M.A. Lawson, M.B. Geuking, B. Beutler, T.F. Tedder, W.D. Hardt, P. Bercik, E.F. Verdu, K.D. McCoy and A.J. Macpherson. Innate and adaptive immunity cooperate flexibly to maintain host-microbiota mutualism. Science 325:617-620, (2009).
• R. Baccala, R. Gonzalez-Quintial, B.R. Lawson, M.E. Stern, D.H. Kono, B. Beutler and A.N. Theofilopoulos. Sensors of the innate immune system: their mode of action. Nat Rev Rheumatol. 5:448-56, (2009).
• K. Flür, R. Allam, D. Zecher, O. P. Kulkarni1, J. Lichtnekert, M. Schwarz1, B. Beutler, V. Vielhauer and H. J. Anders. Viral RNA induces type I interferon-dependent cytokine release and cell death in mesangial cells via melanoma-differentiation-associated gene-5. Implications for viral infection-associated glomerulonephritis. The American Journal of Pathology 175(5):2014-22, (2009). PMCID: PMC2774065
• J. Truksa, T. Gelbart, H. Peng, E. Beutler, B. Beutler and P. Lee. Suppression of the hepcidin-encoding gene Hamp1 permits iron overload in mice lacking both hemojuvelin and matriptase-2/TMPRSS6. British Journal of Haematology 147(4):571-81, (2009).
• D.H. Kono, M.K. Haraldsson, B.R. Lawson, K.M. Pollard, Y.T. Koh, X. Du, C.N. Arnold, R. Baccala, G.J. Silverman, B.A. Beutler and A.N. Theofilopoulos. Endosomal TLR signaling is required for anti-nucleic acid and rheumatoid factor autoantibodies in lupus. Proc Natl Acad Sci USA 106(29):12061-6, (2009). PMCID: PMC2715524
• R. Fukui, S. Saitoh, F. Matsumoto, H. Kozuka-Hata, M. Oyama, K. Tabeta, B. Beutler and K. Miyake. Unc93B1 biases Toll-like receptor responses to nucleic acid in dendritic cells toward DNA- but against RNA-sensing. J Exp Med. 206(6):1339-50, (2009). PMCID: PMC2715051
• P. Borelli, F.E. Barros, K. Nakajima, S.L. Blatt, B. Beutler, J. Pereira, M. Tsujita, G.M. Favero and R.A. Fock. Protein-energy malnutrition halts hemopoietic progenitor cells in the G0/G1 cell cycle stage, thereby altering cell production rates. Braz J Med Biol Res. 42(6):523-30, (2009).
• S.C. Pflugfelder, M.E. Stern; Symposium Participants. Immunoregulation on the ocular surface: 2nd Cullen Symposium. Ocul Surf 7(2):67-77, Review, (2009).
• P. Krebs, M.J. Barnes, K. Lampe, K. Whitley, K.S. Bahjat, B. Beutler, E. Janssen and K. Hoebe. NK cell-mediated killing of target cells triggers robust antigen-specific T cell-mediated and humoral responses. Blood 113(26):6593-602, (2009). PMCID: PMC2710917
• B.A. Beutler. TLRs and innate immunity. Blood 113(7):1399–1407, (2009). PMCID: PMC2644070
• J. Lichtnekert, V. Vielhauer, D. Zecher, O.P. Kulkarni, S. Clauss, S. Segerer, V. Hornung, T.N. Mayadas, B. Beutler, S. Akira and H.J. Anders. Trif is not required for immune complex glomerulonephritis: dying cells activate mesangial cells via Tlr2/Myd88 rather than Tlr3/Trif. Am J Physiol Renal Physiol. 296(4):F867-74, (2009).
• M.J. Barnes, P. Krebs, N. Harris, C. Eidenschenk, R. Gonzalez-Quintial, C.N. Arnold, K. Crozat, S. Sovath, E.M. Moresco, A.N. Theofilopoulos, B. Beutler and K. Hoebe. Commitment to the regulatory T cell lineage requires CARMA1 in the thymus but not in the periphery. PLoS Biology 7(3):e51, (2009). PMCID: PMC2650725
• A.L. Blasius, K. Brandl, K. Crozat, Y. Xia, K. Khovananth, P. Krebs, N.G. Smart, A. Zampolli, Z.M. Ruggeri and B.A. Beutler. Mice with mutations of Dock7 have generalized hypopigmentation and white-spotting but show normal neurological function. Proc Natl Acad Sci USA 106(8):2706-11, (2009). PMCID: PMC2650330
• K. Brandl, S. Rutschmann, X. Li, X. Du, N. Xiao, B. Schnabl, D.A. Brenner and B. Beutler. Enhanced sensitivity to DSS colitis caused by a hypomorphic Mbtps1 mutation disrupting the ATF6-driven unfolded protein response. Proc Natl Acad Sci USA 106(9):3300-5, (2009). PMCID: PMC2651297
• A.K. Kiemer, R.H. Senaratne, J. Hoppstadter, B. Diesel, L.W. Riley, K. Tabeta, S. Bauer, B. Beutler and B.L. Zuraw. Attenuated Activation of Macrophage TLR9 by DNA from Virulent Mycobacteria. Journal of Innate Immunity 1:29-45, (2009).
• B. Beutler. Microbe sensing, positive feedback loops, and the pathogenesis of inflammatory diseases. Immunological Reviews 227:248-263, (2009). PMCID: PMC2713013

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2008 (14 articles)

• A.A. Brzezinska, J.L. Johnson, D.B. Munafo, K. Crozat, B. Beutler, W.B. Kiosses, B.A. Ellis and S.D. Catz. The Rab27a Effectors JFC1/Slp1 and Munc13-4 Regulate Exocytosis of Neutrophil Granules. Traffic9(12): 2151-2164, (2008).
• B.A. Croker, B.R. Lawson, M. Berger, C. Eidenschenk, A.L. Blasius, E.M. Moresco, S. Sovath, L. Cengia, L.D. Shultz, A.N. Theofilopoulos, S. Pettersson and B.A. Beutler. Inflammation and autoimmunity caused by a SHP1 mutation depend on IL-1, MyD88, and a microbial trigger. Proc Natl Acad Sci USA 105:15028-33, (2008). PMCID: PMC2567487
• X. Du, M. Schwander, E.M. Moresco, P. Viviani, C. Haller, M.S. Hildebrand, K. Pak, L. Tarantino, A. Roberts, H. Richardson, G. Koob, H. Najmabadi, A.F. Ryan, R.J. Smith, U. Muller and B. Beutler. A catechol-O-methyltransferase that is essential for auditory function in mice and humans. Proc Natl Acad Sci USA 105:14609-14614, (2008). PMCID: PMC2567147
• J. Chaix, M.S. Tessmer, K. Hoebe, N. Fuseri, B. Ryffel, M. Dalod, L. Alexopoulou, B. Beutler, L. Brossay, E. Vivier and T. Walzer. Cutting Edge: Priming of NK cells by IL-18. J Immunol. 181:1627-31, (2008).
• B. Beutler, I.W. Milsark and A.C. Cerami. Passive immunization against cachectin/tumor necrosis factor protects mice from lethal effect of endotoxin. J Immunol. 181:7-9, (2008).
• X. Du, E. She, T. Gelbart, J. Truksa, P. Lee, Y. Xia, K. Khovananth, S. Mudd, N. Mann, E.M. Moresco, E. Beutler and B. Beutler. The serine protease TMPRSS6 is required to sense iron deficiency. Science 320:1088-92, (2008). PMCID: PMC2430097
• P. Georgel, X. Du, K. Hoebe and B. Beutler. ENU Mutagenesis in Mice. Methods Mol Biol. 415:1-16, (2008).
• M.A. Freudenberg, S. Tchaptchet, S. Keck, G. Fejer, M. Huber, N. Schutze, B. Beutler and C. Galanos. Lipopolysaccharide sensing an important factor in the innate immune response to Gram-negative bacterial infections: Benefits and hazards of LPS hypersensitivity. Immunobiology 213:193-203, (2008).
• K. Hoebe and B. Beutler. Forward genetic analysis of TLR-signaling pathways: An evaluation. Adv Drug Deliv Rev. 60:824-9, (2008).
• B. Beutler and E.M. Moresco. The forward genetic dissection of afferent innate immunity. Curr Top Microbiol Immunol. 321:3-26, (2008).
• B. Beutler. Immunology, phenotype first. Preface. Curr Top Microbiol Immunol.321:v-viii, (2008).
• C.H. Xia, H. Liu, D. Cheung, M. Wang, C. Cheng, X. Du, B. Chang, B. Beutler and X. Gong. A model for familial exudative vitreoretinopathy caused by LPR5 mutations. Hum Mol Genet. 17:1605-12, (2008).
• B. Beutler and E.M. Moresco. Akirins vs. Infection. Nat Immunol. 9:7-9, (2008).
• B. Beutler. The Toll-like Receptors. In:Genetic Susceptibility to Infection. R.L Kaslow, J. McNicholl and A.V.S. Hill, eds. Oxford University Press, pg. 165, (2008).

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2007 (15 articles)

• J. Koehn, D. Huesken, M. Jaritz, A. Rot, M. Zurini, A. Dwertmann, B. Beutler and U. Korthäuer. Assessing the function of human UNC-93B in TLR signaling and MHC II response. Human Immunol., 68:871-78, (2007).
• B. Croker, K. Crozat, M. Berger, Y. Xia, S. Sovath, L. Schaffer, I. Eleftherianos, J.L. Imler and B. Beutler. ATP-Sensitive Potassium channels mediate survival during infection in mammals and insects. Nat. Genet., 39:1453-60, (2007).
• B. Beutler. Neo-ligands for innate immune receptors and the etiology of sterile inflammatory disease. Immunol Rev., 220:113-28, (2007).
• B. Beutler, C. Eidenschenk, K. Crozat, J. Imler, J. Hoffman, O. Takeuchi and S. Akira. Genetic Analysis of Resistance to Viral Infection. Nat. Rev. Immunol., 7:753-766, (2007).
• J. H. Han, S. Akira, K. Calame, B. Beutler, E. Selsing and T. Imanishi-Kari. Class Switch Recombination and Somatic Hypermutation in Early Mouse B Cells Are Mediated by B Cell and Toll-like Receptors. Immunity, 1:64-75, (2007).
• P. Georgel, Z. Jiang, E. Kunz, J. Janssen, K. Mols, K. Hoebe, S. Bahram, M.B.A. Oldstone and B. Beutler. Vesicular stomatitis virus glycoprotein G activates a specific antiviral Toll-like receptor 4-dependent pathway. Virology, 362:304-313, (2007).
• K. R. Taylor, K. Yamasaki, K. A. Radek, A. Di Nardo, H. Goodarzi, D. Golenbock, B. Beutler and R. L. Gallo. Recognition of hyaluronan released in sterile injury involves a unique receptor complex dependent on TLR4, CD44 and MD-2. J. Biol.Chem., 282:18265-75, (2007).
• D. Togbe, L. Schofield, G.E. Grau, B. Schnyder, V. Boissay, S. Charron, S. Rose, B. Beutler, V.F.J. Quesniaux and B. Ryffel. Murine cerebral malaria development is independent of Toll-like receptor signaling. Am. J. Pathol., 170:1640-1648, (2007).
• K. Crozat, K. Hoebe, S. Ugolini, N. A. Hong, E. Janssen, S. Rutschmann, S. Mudd, S. Sovath, E. Vivier and B. Beutler. Jinx, an MCMV susceptibility phenotype caused by disruption of Unc13d: a mouse model of type 3 familial hemophagocytic lymphohistiocytosis. J. Exp. Med., 204:853-863, (2007).
• M.M. Brinkmann, E. Spooner, K. Hoebe, B. Beutler, H.L. Ploegh and Y-M. Kim. The interaction between the ER membrane protein UNC93B and TLRs 3, 7, and 9 is crucial for TLR signaling. J. Cell Biol., 177:265-275, (2007).
• R. Baccala, K. Hoebe, D.H. Kono, B. Beutler and A. N. Theofilopoulos. Toll-like receptor-dependent and independent pathways of Type I interferon induction in systemic autoimmunity. Nat. Med., 13:543-551, (2007).
• D.B. Munafó, J.L. Johnson, B.A. Ellis, S. Rutschmann, B. Beutler and S.D. Catz. Rab27a is a key component of the secretory machinery of azurophilic granules in granulocytes. Biochem. J., 402:229-39, (2007).
• S.O. Kim, S.D. Ha, S. Lee, S. Stanton, B. Beutler and J. Han. Mutagenesis by retroviral insertion in chemical mutagen-generated quasi-haploid mammalian cells. Biotechniques, 42: 493-501, (2007).
• B. Beutler, X. Du and Y. Xia. Precis on forward genetics in mice. Nat. Immunol., 8:659-664 (2007).
• M. Otsuka, Q. Jing, P. Georgel, L. New, J. Chen, J. Mols, Y.J. Kang, Z. Jiang, S.C. Das, A.K. Pattnaik, J. Carlos de la Torre, B. Beutler and J. Han. Hypersusceptibility to vesicular stomatitis virus infection in Dicer-deficient mice is due to impaired miR24 and miR93 expression. Immunity, 27:123-124, (2007).

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2006 (21 articles)

• M. Huber, C. Kalis, S. Keck, Z. Jiang, P. Georgel, X. Du, L. Shamel, S. Sovath, S. Mudd, B. Beutler, C. Galanos and M.A. Freudenberg. R-form LPS, the master key to the activation of TLR4/MD2 positive cells. Eur. J. Immunol., 36:701-711, (2006).
• B. Beutler, Z. Jiang, P. Georgel, K. Crozat, B. Croker, S. Rutschmann, X. Du and K. Hoebe. Genetic analysis of host resistance: Toll-like receptor signaling and immunity at large. Annu. Rev. Immunol., 24:353-389, (2006).
• E. M. Janssen, K. Tabeta, M. Barnes, S. McBride, S. Schoenberger, A.N. Theofilopoulos, B. Beutler and K. Hoebe. Efficient T cell activation via a toll-interleukin 1 receptor-independent pathway. Immunity, 24:787-799, (2006).
• K. Tabeta, K. Hoebe, E.M Janssen, X. Du, P. Georgel, K. Crozat, S. Mudd, N. Mann, S. Sovath, J. Goode, L. Shamel, A. Herskovits, D. Portnoy, M. Cooke, L.M. Tarantino, T. Wiltshire, B.E. Steinberg, S. Grinstein and B. Beutler. The Unc93b1 mutation 3d disrupts exogenous antigen presentation signaling via Toll-like receptors 3, 7, and 9. Nat. Immunol. 7:156-164, (2006).
• S. Rutschmann, K. Hoebe, J. Zalevsky, X. Du, N. Mann, B.I. Dahiyat, P. Steed and B. Beutler. PanR1, a dominant negative missense allele of Tumor Necrosis Factor a , does not impair lymphoid development. J. Immunol., 176:7525-7532, (2006).
• K. Crozat, P. Georgel, S. Rutschmann, N. Mann, X. Du, K. Hoebe and B. Beutler. Analysis of the MCMV resistome by ENU mutagenesis. Mamm. Genome, 17:398-406, (2006).
• Z. Jiang, P. Georgel, C. Li, J. Choe, K. Crozat, S. Rutschmann, X. Du, T. Bigby, S. Mudd, S. Sovath, I.A. Wilson, A. Olson and B. Beutler. Details of Toll-like receptor: adapter interaction revealed by germline mutagenesis. Proc. Natl. Acad. Sci. U.S.A., 103:10961-10966, (2006).
• D. Nemazee, A.L. Gavin, K. Hoebe, and B. Beutler. Commentary: The TLR independence of antibody responses. Nature, 441: E4, (2006).
• K. Hoebe, Z. Jiang, K. Tabeta, X. Du, P. Georgel, K. Crozat and B. Beutler. Genetic analysis of innate immunity. Adv. in Immunol., 91:175-226, (2006).
• K. Hoebe, Z. Jiang, P. Georgel, K. Tabeta, E. Janssen, X. Du and B. Beutler. TLR signaling pathways: Opportunities for activation and blockade in pursuit of therapy. Curr. Pharm. Des, 12: 4123-4134, (2006).
• H. Fischer, M. Yamamoto, S. Akira, B. Beutler and C. Svanborg. Mechanism of pathogen-specific TLR4 activation in the mucosa: fimbriae, recognition receptors and adaptor protein selection. Eur. J. Immunol., 36:267-277, (2006).
• C.H. Xia, H. Liu, D. Cheung, C. Cheng, E. Wang, X. Du, and B. Beutler. Diverse gap junctions modulate distinct mechanisms for fiber cell formation during lens development and cataractogenesis. Development, 133: 2033-2040, (2006).
• K. Hoebe and B. Beutler. TRAF3: a new component of the TLR-signaling apparatus. Trends Mol. Med., 12:187-189, (2006).
• L. Gitlin, W. Barchet, S. Gilfillan, M. Cella, B. Beutler, R.A. Flavell, M.S. Diamond and M. Colonna. Essential role of mda-5 in type I IFN responses to polyriboinosinic: polyribocytidylic acid and encephalomyocarditis picornavirus. Proc. Natl. Acad. Sci. U.S.A., 103:8459-8464, (2006).
• Y. Kinjo, E. Tupin, D.Wu, M. Fujio, R. Garcia-Navarro, M.R-E-I. Benhnia, D.M. Zajonc, G. Ben-Menachem, G.D. Ainge, G.F. Painter, A. Khurana, K. Hoebe, S.M. Behar, B. Beutler, I.A. Wilson, M. Tsuji, T.J. Sellati, C-H. Wong and M. Kronenberg. Natural killer T cells recognize diacylglycerol antigens from pathogenic bacteria. Nat. Immunol., 7:978-986, (2006).
• A. Casrouge, S-Y Zhang, C. Eidenschenk, E. Jouanguy, A. Puel, K. Yang, A. Alcais, C. Picard, N. Mahfoufi, N. Nicolas, L. Lorenzo, S. Plancoulaine, B. Senechal, F. Geissmann, K. Tabeta, K. Hoebe, X. Du, R. L. Miller, B. Heron, C. Mignot, T. B. de Villemeur, P. Lebon, O. Dulac, F. Rozenberg, B. Beutler, M. Tardieu, L. Abel and J-L. Casanova. Herpes simplex virus encephalitis in human UNC-93B deficiency. Science, 314:308-12, (2006).
• D. Togbe, G. Aurore, N. Noulin, V.F. Quesnizux, S. Schnyder-Candrian, B. Schnyder , V. Vasseur, S. Akira, K. Hoebe, B. Beutler, B. Ryffel and I. Couillin. Nonredundant roles of TIRAP and MyD88 in airway response to endotoxin, independent of TRIF, IL-1 and IL-18 pathways. LabInvest., 86:1126-1135, (2006).
• T.P. Meehan, K. Tabeta, X. Du, L.S. Woodward, K. Firozi, B. Beutler and M.J. Justice. Point mutations in the melanocortin-4 receptor cause variable obesity in mice. Mamm. Genome, 17:1162-1171, (2006).
• A.L. Gavin, B. Duong, T. Ota, K. Hoebe, B. Beutler and D. Nemazee. Adjuvant-enhanced antibody responses in the absence of toll-like receptor signaling. Science, 314:1936-1938, (2006).
• B. Beutler. Fighting malaria: mosquitoes know how. Immunity, 25:530-531, (2006).
• C.H. Xia, H. Liu, M. Wang, D. Heung, A. Park, Y. Yang, X. Du, B. Chang, B. Beutler and X. Gong. Characterization of mouse mutants with abnormal RPE cells. Adv. Exp. Med. Biol., 572:95-100, (2006).

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2005 (20 articles)

• A.N. Theofilopoulos, R. Baccala, B. Beutler and D.H. Kono. Type I interferons (a/ß) in immunity and autoimmunity. Annu. Rev. of Immunol., 23:307-335, (2005).
• B. Beutler, K. Hoebe, P. Georgel and X. Du. Forward genetic analysis of TLR pathways: A shared system for the detection of endotoxin and viral infection. Editor: T. Rich. In: Toll and Toll-like receptors: an immunologic perspective, Kluwer Academic/Plenum publishers, New York, NY, pages 168-177, (2005).
• K. Hoebe, P. Georgel, S. Rutschmann, X. Du, S. Mudd, K. Crozat, S. Sovath, L. Shamel, T. Hartung,U. Zahringer and B. Beutler. CD36 is a sensor of diacylglycerides. Nature, 433:523-527, (2005).
• T.R. Hawn, A. Verbon, M. Janer, L.P. Zhao, B. Beutler and A. Aderem. Toll-like receptor 4 polymorphisms are associated with resistance to Legionnaires disease. Proc. Natl. Acad. Sci. U.S.A., 102:2487-2489, (2005).
• B. Beutler, K. Crozat, J.A. Koziol and P. Georgel. Genetic dissection of innate immunity to infection: The mouse cytomegalovirus model. Curr. Opin. Immunol., 17:36-43, (2005).
• J. Mattner, K.L. DeBord, N. Ismail, R.D. Goff, C. Cantu III, D. Zhou, P. Sait-Mezard, V. Wang, Y. Gao, N. Yin, K. Hoebe, O. Schneewind, D. Walker, B. Beutler, L. Teyton, P.B. Savage and A. Bendelac. Both exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections. Nature 434:525-529, (2005).
• P. Georgel, K. Crozat, X. Lauth, S. Sovath, K. Hoebe, X. Du, S. Rutschmann, Z. Jiang, T. Bigby, V. Nizet and B. Beutler. A TLR2-responsive lipid effector pathway protects mammals against Gram-positive bacterial infections. Infect. Immun., 73:4512-4521, (2005).
• Z. Zhou, K. Hoebe, X. Du, Z. Jiang, L. Shamel and B. Beutler. Antagonism between MyD88- and TRIF-dependent signals in B7RP-1 upregulation. Eur. J. Immunol., 35:1918-1927, (2005).
• Z. Jiang, P. Georgel, X. Du, L. Shamel, S. Sovath, S. Mudd and B. Beutler. CD14 is required for MyD88-independent LPS signaling. Nat. Immunol., 6:565-570, (2005).
• K. Hoebe and B. Beutler. Unraveling innate immunity using large scale ENU mutagenesis. Tissue Antigens, 65:395-401, (2005).
• B. Beutler and J-L. Casanova. New frontiers in immunology: Workshop on the Road Ahead: Future directions in fundamental and clinical immunology. EMBO Rep., 6:620-623, (2005).
• B. Beutler, K. Hoebe, P. Georgel, K. Tabeta and X. Du. Genetic analysis of innate immunity: identification and function of the TIR adapter proteins. Adv. Exp. Med. Biol., 560:29-39 (2005).
• K.I. Kim, O. Malakhova, K. Hoebe, M. Yan, B. Beutler and D-E. Zhang. Enhanced anti-bacterial potential in UBP43-deficient mice against Salmonella typhimurium infection by up-regulation type I IFN-signaling. J. Immunol., 175:847-854, (2005).
• B. Beutler. The Toll-like receptors: Analysis by forward genetic methods. Immunogenetics, 57:385-392, (2005).
• C.W. Wieland, S. Florquin, N.A. Maris, K. Hoebe, B. Beutler, K. Takeda, S. Akira and T. van der Poll. The MyD88 dependent but not the MyD88 independent pathway of Toll-like receptor 4 signaling is important in clearing non-typeable Haemophilus influenzae from the mouse lung. J. Immunol., 175:6042-6049, (2005).
• X. Du, K. Tabeta, K. Hoebe, N. Mann, K. Crozat, S. Mudd, and B. Beutler. An essential role for Rxr a in Th2 development. Eur. J. Immunol, 35:3414-3423, (2005).
• B. Beutler. Innate Immunity. In: Williams Hematology, 7th Edition. Lichtman, M.A., Beutler, E., Kipps, T.J., Seligsohn, U., Kaushansky, K., and Prchal, J.T., eds. McGraw-Hill Medical Press, New York, NY, pp. 231-238, (2005).
• B. Beutler, P. Georgel, B. Croker and K. Crozat. Genetic analysis of innate resistance to mouse cytomegalovirus (MCMV). Brief. Funct. Genomic Proteomic, 4:203-213, (2005).
• H.Q. Liu, X. Du, M. Wang, Q.L. Huang, L.L. Ding, H.W. McDonald, J.R. Yates, B. Beutler, J. Horwitz and X.H. Gong. Crystallin gamma B-14F mutant protein binds to alpha-crystallin and affects lens transparency. J.Biol.Chem. 280:25071-25078, (2005).
• B. Beutler. Microbial Pathogenesis and the discovery of Toll-like receptor function. In: Vaccine Adjuvants: Immunological and Clinical Principles. Hackett, C., and Harn, D.A., eds. Humana Press, Totowa, NJ, pg. 1-24, (2005).

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2004 (16 articles)

• X. Du, K. Tabeta, K. Hoebe, H. Liu, N. Mann, S. Mudd, K. Crozat, S. Sovath, X. Gong and B. Beutler. Velvet, a dominant Egfr mutation that causes wavy hair and defective eyelid development in mice. Genetics, 166:331-340, (2004).
• K. Tabeta, P. Georgel, E.M. Janssen, X. Du, K. Hoebe, K. Crozat, S. Mudd, L. Shamel, S. Sovath, J. Goode, L. Alexopoulou, R. Flavell and B. Beutler. TLR9 and TLR3 as essential components of innate immune defense against mouse cytomegalovirus infection. Proc. Natl. Acad. Sci. U.S.A., 101:3516-3521, (2004).
• N. Anfossi, S.H. Robbins, S. Ugolini, P. Georgel, K. Hoebe, C. Bouneaud, C. Ronet, A. Kaser, C.B. DiCioccio, E. Tomasello, B. Beutler, S.L. Reiner, L. Alexopoulou, O. Lantz , D.H. Raulet, L. Brossay and E. Vivier. Expansion and Function of CD8+ T Cells Expressing Ly49 Inhibitory Receptors Specific for MHC Class I Molecules. J. Immunol., 173:3773-3782, (2004).
• K. Crozat and B. Beutler. TLR7: A new sensor of viral infection. Proc. Natl. Acad. Sci. U.S.A., 101:6835-6836, (2004).
• B. Beutler. Preview: SHIP, TGF-ß, and Endotoxin Tolerance. Immunity, 21:134-135, (2004).
• K. Hoebe, E.M. Janssen and B. Beutler. The Interface between Innate and Adaptive Immunity. Nat. Immunol., 5:971-974, (2004).
• B. Beutler. The Toll-like receptors and their place in immunology: Where does the immune response to infection begin? Nat. Rev. Immunol., 4:498 (2004).
• B. Beutler. Inferences, questions and possibilities in Toll-like receptor signaling. Nature, 430:257-263, (2004).
• K. Hoebe and B. Beutler. LPS, dsRNA and the interferon bridge to adaptive immune responses: Trif, Tram, and other TIR adaptor proteins. J. Endotoxin Res., 10:130-136, (2004).
• I. Smythe, X. Du, M.S. Taylor, M. Justice, B. Beutler and I.J. Jackson. The extracellular matrix gene Frem1 is essential for the normal adhesion of the embryonic epidermis. Proc. Natl. Acad. Sci. U.S.A., 101:13560-13565, (2004).
• H. Weighardt, G. Jusek, J. Mages, R. Lang, K. Hoebe, B. Beutler and B. Holzmann. Identification of a TLR4- and TRIF-dependent activation program of dendritic cells. Eur. J. Immunol., 34:558-564, (2004).
• B. Beutler. Innate Immunity: an overview. Mol. Immunol., 40:845-859, (2004).
• B. Beutler, K. Hoebe and L. Shamel. Forward genetic dissection of afferent immunity: the role of TIR adapter proteins in innate and adaptive immune responses. C. R. Biol., 327:571-80, (2004).
• B. Beutler and J. Hoffmann. Innate immunity: Editorial overview. Curr. Opin. Immunol., 16:1-3, (2004).
• B. Beutler, K. Hoebe, P. Georgel, K. Tabeta and X. Du. Genetic analysis of innate immunity: TLR adapter proteins in innate and adaptive immune responses. Microbes Infection, 6:1374-1381, (2004).
• E.T. Rietschel, M. Rietschel and B. Beutler. How the mighty have fallen: fatal infectious diseases of divine composers. Editors: B.A. Cunha and R.C. Moellering. In: Infectious Diseases Clinics of North America, W.B. Saunders Company, Philadelphia, PA, 18:311-339, (2004).

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2003 (17 articles)

• B. Beutler. Toll-like Receptors: The Origins of Inflammation. In: The Cytokine Handbook 4th Edition. T.A. Thomson and M.T. Lotze eds., Academic Press, 809-822, (2003).
• B. Beutler and S. Beutler. The pathogenesis of fever. In: Cecil Textbook of Medicine 22nd Edition. D. Ausiello eds., W.B. Saunders, Philadelphia, PA, (2003).
• K. Hoebe, X. Du, J. Goode, N. Mann and B. Beutler. Lps2: a new locus required for responses to lipopolysaccharide, revealed by germline mutagenesis and phenotypic screening. J.Endotox.Res., 9:250-255, (2003).
• I. Smirnova, N. Mann, A. Dols, H.H. Derkx, M. Hibberd, M. Levin and B. Beutler. Assay of locus-specific genetic load implicates rare TLR4 mutations in meningococcal susceptibility. Proc. Natl. Acad. Sci. U.S.A., 100:6075-6080, (2003).
• K. Hoebe, X. Du, P. Georgel, E.M. Janssen, K. Tabeta, S.O. Kim, J. Goode, P. Lin, N. Mann, S. Mudd, K. Crozat, S. Sovath, J. Han and B. Beutler. Identification of Lps2 as a key transducer of MyD88-independent TIR signalling. Nature, 424:743-748, (2003).
• K. Hoebe, E.M. Janssen, S.O. Kim, L. Alexopoulou, R.A. Flavell, J. Han and B. Beutler. Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded RNA occurs by Trif-dependent and Trif-independent pathways. Nat. Immunol., 4:1223-1229, (2003).
• T.R. Hawn, A. Verbon, K.D. Lettinga, L.P. Zhao, S.S. Li, R.J. Laws, S.J. Skerrett, B. Beutler, L. Schroeder, A. Nachman, A. Ozinsky, K.D. Smith and A. Aderem. A common dominant TLR5 stop codon polymorphism abolishes flagellin signaling and is associated with susceptibility to legionnaires' disease. J. Exp. Med., 198:1563-1572, (2003).
• B. Beutler. Innate immune responses to microbial poisons: Discovery and function of the Toll-like receptors. Annu. Rev. Pharmacol. Toxicol., 43:609-628, (2003).
• B. Beutler. Key inflammatory and stress pathways in critical illness the central role of the Toll-like receptors. Crit. Care, 7:39-46, (2003).
• B. Beutler and E.T. Rietschel. Innate immune sensing and its roots: the story of endotoxin. Nat. Rev. Immunol., 3:169-176, (2003).
• B.J. Stevenson, C. Iseli, B. Beutler and C.V. Jongeneel. Using transcriptome data to unravel the fine structure of genes involved in sepsis. J. Infect. Dis., 187:S308-S314, (2003).
• B. Beutler. TNF In: Encyclopedia of Hormones & Related Cell Regulators. H.L. Henry and A.W. Norman eds., Academic Press, San Diego, CA. 536-539, (2003).
• B. Beutler, X. Du and K. Hoebe. From phenomenon to phenotype, and from phenotype to gene: forward genetics and the problems of sepsis. J. Infect. Dis., 187:S321-326, (2003).
• B. Beutler, K. Hoebe, X. Du and R.J. Ulevitch. How we detect microbes and respond to them: the Toll-like receptors and their transducers. J. Leukoc. Biol., 74:479-485, (2003).
• B. Beutler, K. Hoebe, X. Du, E.M. Janssen, P. Georgel and K. Tabeta. Lps2 and signal transduction in sepsis: at the intersection of host responses to bacteria and viruses. Scan.J. Infect.Dis., 35:563-567, (2003).
• B. Beutler. Not "molecular patterns" but molecules. Immunity, 19:155-156 (2003).
• S.O. Kim, Q. Jing, K. Hoebe, B. Beutler, N.S. Duesbery and J. Han. Sensitizing anthrax lethal toxin-resistant macrophages to lethal toxin-induced killing by tumor necrosis factor-a. J. Biol. Chem., 278:7413-7421, (2003).

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2002 (7 articles)

• B. Beutler. Toll-like receptors: how they work and what they do. Curr. Opin. Hematol. 9:2-10, (2002).
• B. Beutler. . Wien. Med. Wochenschr., 152:547-551, (2002). >
• B. Beutler. Endotoxin antagonism: conceptual basis and therapeutic potential. Expert Opin. Ther. Targets, 6:147-158, (2002).
• B. Beutler. TLR4 as the mammalian endotoxin sensor. In: Curr. Top. Microbiol. Immunol., B. Beutler and H. Wagner eds., Springer-Verlag, 109-120, (2002).
• B. Beutler and M. Rehli. Evolution of the TIR, Tolls and TLRs: functional inferences from computational Biology. Curr. Top. Microbiol. Immunol., B. Beutler and H. Wagner eds., Springer-Verlag, 1-21, (2002).
• B. Beutler. LPS in microbial pathogenesis: promise and fulfillment. J. Endotox. Res., 8:329-335, (2002).
• B.Beutler and E. Beutler. Toll-like recetpor 4 polymorphisms and atherogenesis. New Engl. J. Med., 347:1978-1979, (2002).

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2001 (13 articles)

• I. Smirnova, M. Hamblin, C. McBride, B. Beutler and A. di Rienzo. Excess of rare amino acid polymorphisms in the Toll-like receptor 4 in humans. Genetics, 158:1657-1664, (2001).
• B. Beutler. Innate Immune Sensing and the Toll-like Receptors. In: The Liver: Biology and Pathobiology. I.M. Arias, J.L. Boyer, F.V. Chisari, et al., eds., 4th Edition, Lippincott, Williams & Wilkins, Philadelphia, PA, 581-589, (2001).
• B. Beutler and A. Poltorak. Toll we meet again. Nat. Immunol., 2:9-10, (2001).
• B. Beutler and A. Poltorak. The sole gateway to endotoxin response: how Lps was identified as Tlr4, and its role in innate immunity. Drug Metab. Dispos., 29:474-78, (2001).
• B. Beutler and A. Poltorak. The Search for Lps: 1993-1998. J. Endotox. Res. 6:269-293, (2001).
• B. Beutler. The Toll-like receptors as the primary sensors of the innate immune system. The Immunologist 8:123-130, (2001).
• D. Kimbrell and B. Beutler. Evolution and genetics of innate immunity. Nat. Rev., 2:256-267, (2001).
• B. Beutler, X. Du and A. Poltorak. Identification of Toll-like receptor 4 (TLR4) as the sole conduit for LPS signal transduction: genetic and evolutionary studies. J. Endotox. Res., 7:277-280, (2001).
• B. Beutler and A. Poltorak. Sepsis and the evolution of the innate immune response. Crit. Care Med., 29:S2-7, (2001).
• B. Beutler. Autoimmunity and apoptosis: The Crohn's connection. Immunity, 15:5-14, (2001).
• H.R. Redl, A. Aderem, B. Beutler, T. Calandra, J.P. Mira and R. Ulevitch. Clinical expert round table discussion (session 1) at the Margaux Conference on Critical Illness: innate immunity: host recognition of and sensitivity to bacterial components. Crit. Care Med., 29:S19-20, (2001).
• R. Ulevitch and B. Beutler. Genetic analysis of host responses in sepsis. Curr. Infect. Dis. Rep., 3:419-426, (2001).
• B. Beutler. Sepsis begins at the interface of pathogen and host. Biochem. Soc. Trans., 29:853-859, (2001).

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2000 (9 articles)

• A. Poltorak, P. Ricciardi-Castagnoli, S. Citterio and B. Beutler. Physical contact between LPS and TLR4 revealed by genetic complementation. Proc. Natl. Acad. Sci. U.S.A., 97:2163-2167, (2000).
• I. Smirnova, A. Poltorak, E.K.L. Chen, C. McBride and B. Beutler. Phylogenetic variation and polymorphism at the toll-like receptor 4 locus (TLR4). Genome Biol., 1:1-10, (2000).
• J. Nattermann, X. Du, Y. Wei, D. Shevchenko and B. Beutler. Endotoxin-mimetic effect of antibodies against Toll-like receptor 4. J. Endotox. Res., 6:257-264, (2000).
• A. Poltorak, I. Smirnova, R. Clisch and B. Beutler. Limits of a deletion spanning Tlr4 in C57BL/10ScCr mice. J.Endotox.Res., 6:51-56, (2000).
• X. Du, A. Poltorak, Y. Wei and B. Beutler. Three novel mammalian toll-like receptors: gene structure, expression, and evolution. Eur. Cytokine Netw., 11:362-371, (2000).
• M. Rehli, A. Poltorak, L. Schwarzfischer, S.W. Krause, R. Andreesen and B. Beutler. PU.1 and interferon consensus sequence-blinding protein regulate the myeloid expression of the human Toll-like receptor 4 gene. J. Biol. Chem., 275:9773-9781, (2000).
• B. Beutler. Endotoxin, Toll-like receptor 4, and the afferent limb of innate immunity. Curr. Opin. Microbiol., 3:23-28, (2000).
• B. Beutler. TLR4: Central component of the sole mammalian LPS sensor. Curr. Opin. Immunol., 12:20-26, (2000).
• B. Beutler and A. Poltorak. Positional cloning of Lps and the general role of toll-like receptors in the innate immune response. Eur. Cytokine Netw., 11:143-152, (2000).

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1999 (3 articles)

• J.A. Koziol and B. Beutler. Estimation of physical distance in the genome through probabilistic analysis of marker density and yeast artificial chromosome (YAC) size. Biom. J., 41: 251-257, (1999).
• G.R. Brown, G. Lindberg, J. Meedings, M. Silva, B. Beutler and D.Thiele. Tumor necrosis factor inhibitor ameliorates murine intestinal graft-versus-host disease. Gastroenterology, 116:593-601, (1999).
• X. Du, A. Poltorak, M. Silva and B. Beutler. Analysis of Tlr4-mediated LPS signal transduction in macrophages by mutational modification of the receptor. Blood Cells Mol. Dis., 25:328-338, (1999).

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1998 (4 articles)

• A. Poltorak, I. Smirmova, X. He, M.-Y. Liu, C. Van Huffel, O. McNally, D. Birwell, E. Alejos, M. Silva, X. Du, P. Thompson, E.K.L. Chan, J. Ledesma, B. Roe, S. Clifton, S. Vogel and B. Beutler. Genetic and physical mapping of the Lps locus: Identification of the Toll-4 receptor as a candidate gene in the critical region. Blood Cells Mol. Dis., 24:340-355, (1998).
• A. Poltorak, X. He, I. Smirnova, M.-Y. Liu, C. Van Huffel, X. Du, D. Birdwell, E. Alejos, M. Silva, C. Galanos, M. Freudenberg, P. Ricciardi-Castagnoli, B. Layton and B. Beutler. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in the TLR4 gene. Science, 282:2085-2088, (1998).
• B. Beutler and F. Bazzoni. TNF, apoptosis and autoimmunity: a common thread? Blood Cells Mol. Dis., 24:216-230, (1998).
• G.R. Brown, M.D. Silva, P.A. Thompson and B. Beutler. Lymphoid hyperplasia, CD45RB high/low T cell imbalance, and suppression of type I diabetes mellitus result from TNF blockade in NOD 6 NOD-scid adoptive T cell transfer. Diabetologia, 41:1502-1510, (1998).

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