We seek to understand the mammalian immune system's molecular machinery against infections of all kinds, and to produce and archive mutations affecting mouse genetic function.
How do we "know" when we have an infection? What receptors alert us? With the tools of genetics, answers are emerging.
Mutagenetix is a database of ENU-induced mutations in the mouse genome and their phenotypes, immunological and otherwise.
Mutation of the ER retention receptor KDELR1 leads to cell-intrinsic lymphopenia and a failure to control chronic viral infection. Proc Natl Acad Sci USA, Oct 2015; 112(42):E5706-14.
Atp7a – brown. ATPase, Cu++-transporting, alpha polypeptide.
Rhbdf2 (iRhom2) – sinecure. Rhomboid 5 homolog 2.