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Our goals

We seek to understand the mammalian immune system's molecular machinery against infections of all kinds, and to produce and archive mutations affecting mouse genetic function.

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Our discoveries

The Beutler lab discovered the Toll-like receptors as molecular sensors of infection. This was achieved by a classical genetic approach: the positional cloning of mutations that prevented responses to bacterial lipopolysaccharide (LPS). This work was recognized by the 2011 Nobel Prize in Physiology or Medicine.

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Our approach

We begin with phenotypes induced by chemical mutagenesis, identify the causative mutations, and then determine precisely how they cause abnormal function. We also sequence and store the affected DNA for future use.

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Our methods

We use classical genetics, empowered by modern tools, to decipher gene function. Our "phenotype first" approach assures an unbiased search for the proteins that affect specific biological phenomena.

The Major Questions

How do we "know" when we have an infection? What receptors alert us? With the tools of genetics, answers are emerging.

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Mutagenetix

Mutagenetix is a database of ENU-induced mutations in the mouse genome and their phenotypes, immunological and otherwise.

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New Genes

Atp7a – brown. ATPase, Cu++-transporting, alpha polypeptide.

Rhbdf2 (iRhom2) – sinecure. Rhomboid 5 homolog 2.
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