We seek to understand the mammalian immune system's molecular machinery against infections of all kinds, and to produce and archive mutations affecting mouse genetic function.
How do we "know" when we have an infection? What receptors alert us? With the tools of genetics, answers are emerging.
Mutagenetix is a database of ENU-induced mutations in the mouse genome and their phenotypes, immunological and otherwise.
Massively parallel exome sequencing: source of thousands of new mouse models, Open Biol, Aug 2012
Roles for Nfkbid, Zeb1, and Ruvbl2 in humoral immunity, PNAS, July 2012
Atp7a – brown. ATPase, Cu++-transporting, alpha polypepitide.
Rhbdf2 (iRhom2) – sinecure. Rhomboid 5 homolog 2.