Program Faculty
Chair: Russell DeBose-Boyd
Stefan Andersson -- Steroid hormone action and metabolism; biochemistry, pharmacology, and genetics of 17b-hydroxysteroid dehydrogenases.
Richard Auchus -- Biochemical, structural, and genetic studies of the enzymes and pathways of steroid hormone biosynthesis in human beings.
Michael Brown -- Regulation of gene expression; cell-surface receptor function; genetics and biochemistry of lipoprotein and cholesterol metabolism.
Richard Bruick -- Regulation of the mammalian hypoxic response pathway.
Igor Butovich -- Lipidomics; ocular (bio)chemistry; molecular enzymology; lipoxygenases, lipid peroxidation, and arachidonic acid cascade.
Chuo Chen -- Naturalproduct synthesis, synthetic methodology development, small molecule library synthesis and chemical biology.
David Chuang -- Structure and function of macromolecular machines; mechanism of chaperone-mediated protein folding.
Nicholas Conrad -- gene expression and RNA biogenesis in Kaposi's sarcoma-associated herpesvirus.
David Corey -- Engineering proteins and nucleic acids for novel function.
Russell DeBose-Boyd -- Regulation of HMG-CoA reductase and sterol metabolism.
Jef De Brabander -- Synthesis of natural products and other molecular architectures and interrogation of their mode-of-action using molecular pharmacology and biochemistry.
George DeMartino -- Biochemical mechanisms and regulation of intracellular protein degradation; structure and function of intracellular proteases.
Victoria Esser -- Molecular biology of carnitine palmitoyltransferase; tissue-specific knockout mouse of muscle CPT I.
Kevin H. Gardner -- Biophysical and biochemical studies of photosensors and other environmental sensors.
Marie-Alda Gilles-Gonzalez -- Mechanisms of O2, CO and NO sensing and in novel signal-transduction heme proteins.
Elizabeth Goldsmith -- Crystallographic studies of recognition and signal transduction in protein molecules.
Joseph Goldstein -- Genetics and biochemistry of lipoprotein and cholesterol metabolism; cell-surface receptor function; regulation of gene expression.
Bethany Janowski -- Gene regulation by small RNAs
Jennifer Kohler -- understanding and exploiting the molecular foundations of glycoconjugate biosynthesis
Mark Lehrman -- Informational carbohydrates in the endoplasmic reticulum: roles in protein folding, stress responses and human disease.
Wen-Hong Li -- Intercellular communications through gap junctions; molecular engineering of fluorescent sensors for cellular imaging; wide field, confocal and multi-photon fluorescence microscopy; mechanisms and functions of cellular calcium signaling.
Qinghua Liu -- Cellular use of small RNAs to specifically silence gene expression; harnessing the power of RNAi to shut down expression of pathological genes to cure human disease.
John MacMillan -- Isolation and structural determination of biologically active natural products from marine bacteria; new methodology for stereochemical assignment; medicinal chemistry.
Steven McKnight -- Molecular genetics and biochemical studies of mammalian gene regulation.
Carole Mendelson -- Molecular mechanisms in tissue-specific, developmental and hormonal regulation of eukaryotic gene expression.
Marc Mumby -- Signaling pathways controlling cell growth and transformation.
Kim Orth -- Signal transduction in the microbial pathogen Yersinia pestis.
Steven Patrie --
Margaret Phillips -- Polyamine and pyrimidine metabolism in trypanosome and malaria parasites.
Rama Ranganathan -- Biophysical mechanisms that underlie cellular signal transduction in sensory neurons.
Joseph Ready -- Discovery and application of new chemical reactions; total synthesis of complex molecules.
Michael Rosen -- Analysis of structural, biochemical, and cell biological mechanisms that regulate the actin cytoskeleton.
Vanessa Sperandio -- Quorum sensing in enteropathogenic Escherichia coli
Uttam Tambar - Synthesis of complex biologically active natural products, and development of new tandem methodologies.
Diana Tomchick -- Structural characterization of signal-transduction protein complexes, proteins involved in reproductive biology and novel proteins from pathogenic bacteria; improved methods of crystallographic data collection, processing and phasing; automated crystallization techniques.
Benjamin Tu -- metabolic oscillation and the mechanisms by which cellular processes are coupled to cyclic changes in metabolic or redox state in time
Kosaku Uyeda -- Elucidation of biochemical mechanisms for regulation of carbohydrate metabolism in mammalian cells.
Xiaodong Wang -- Biochemistry of mammalian apoptosis, chemical synthesis of inhibitors of apoptosis.
Noelle Williams -- Development of novel chemical leads from high throughput screens, new natural products, or rational target-based chemical design as viable therapeutics for preclinical models; areas explored include pharmacokinetics, formulation, metabolism, toxicology, and efficacy for a variety of disease models, including cancer, bacterial infections, and neurological disorders
Wade Winkler -- RNA biology; biochemistry of gene regulation; RNA structure and function; posttranscriptional genetic control; microbial metabolism.
Jin Ye -- Geranylgeranylation and HCV replication; regulation of geranylgeranyl lipid homeostasis; regulated intramembrane proteolysis.
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