Gregory Clark, MD

Assistant Professor
Internal Medicine

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

gregory.clark@utsouthwestern.edu

To make an appointment, call 214-645-8300.

Biography

Dr. Clark is interested in studying type 1 diabetes. Type 1 diabetes is caused by autoimmune destruction of the insulin producing pancreatic beta cells and it typically develops during childhood. Unlike the more common type 2 diabetes, type 1 diabetes is not associated with obesity. Patients with type 1 diabetes live a lifetime dependent upon multiple injection of insulin per day. They must also carefully consider food intake and the effects of exercise and stress on blood glucose. To keep blood glucose from going dangerously high or low, patients must do fingersticks up to 10 times per day to help guide insulin and diet therapy. The daily burden of disease management is considerable. As a result, most patients are unable to adhere to a regimen that prevents complications such as blindness, nerve and kidney disease, stroke and heart attack. Clinically, Dr Clark is determined to achieve the highest level of medical management for type 1 diabetes while taking into account the psychological and social manifestations of adhering to the strict regimen that is necessary to prevent complications. This includes the use of novel technologies including insulin pumps, other novel methods of insulin delivery and continuous glucose monitors. He is also interested in the development of diabetes management programs that utilize the skills of many professionals such as nutritionists, diabetes educators, psychologists and endocrinologists. Understanding the limitations of medical management, Dr. Clark’s laboratory research is focused on finding a cure for type 1 diabetes. He has investigated both adult and embryonic stem cells for their ability to repair or replace insulin producing beta cells that are destroyed in type 1 diabetes. Dr. Clark’s current research focuses on pancreatic development and regeneration and other cellular therapies for diabetes such as islet transplantation

Education

FellowshipJohns Hopkins Hospital, Endocrinology & Metabolism (2005)
Internship/ResidencyJohns Hopkins Hospital, Internal Medicine (2002)
Medical SchoolKeck School of Medicine of University of Southern California (1999)

Publications

Leptin therapy in insulin-deficient type 1 diabetes

Wang M, Chen L, Clark GO, Lee Y, Stevens RD, Ilkayeva OR, Wenner BR, Bain JB, Charron MJ, Newgard CB, Unger, RH , Proceedings of the National Academy of Sciences , Fall 2010; (107):4813-4819

Lipid Homeostasis, Lipotoxicity and the Metabolic Syndrome

Unger, RH, Clark, GO, Scherer, PE, Orci, L , Biochim Biophys Acta , Fall 2010; (1801):209-214

Glucose responsive insulin production from human embryonic germ cell derivatives

Clark GO, Yochem RL, Axelman J, Sheets TP, Kaczorowski DJ, Shamblott MJ , Biochemical and Biophysical Research , Fall 2007; (356/3):587-93

Cell therapies for the treatment of type 1 diabetes mellitus

Shamblott, MJ and Clark GO , Expert Opinion on Biological Therapy , Fall 2004; (4):269-77

Decreased phosphorylation of a low molecular weight protein by cGMP-dependent protein kinase in variant HL-60 cells resistant to nitric oxide- and cGMP-induced differentiation

J., Pilz R., Clark G., Gupta N., Loo D., Martis P., Boss , Molecular and Cell Biology , Fall 1998; (1975):111-121

Honors/Awards

Daniel W. Foster Award for Excellence in Clinical Teaching

Division of Endocrinology, UT Southwestern (2009)

Basic Science Fellows Award, Department of Medicine Research Retreat,

John Hopkins University (Inaugural recipient) (2004)

C. Michael Armstrong Fellow for Stem Cell Research

Institute for Cell Engineering, John Hopkins University (Inaugural recipient) (2004)

Professional Associations/Affiliations

American Diabetes Association

Board of Directors, Executive Committee, Juvenile Diabetes Research Foundation, Dallas Chapter

Endocrine Society