Xuewu Zhang, PhD

Assistant Professor
Endowed Title: Virginia Murchison Linthicum Scholar in Medical Research 2007-2011
Pharmacology, Biochemistry
Graduate Program: Molecular Biophysics

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

Office Phone: 214-645-6116
Office Fax: 214-645-6138

xuewu.zhang@utsouthwestern.edu

Education

Graduate SchoolAlbert Einstein College of Medicine, Cell Biology (2003)

Research Interests

Signal transduction
Structural biology

Publications

Featured
Crystal structure of the plexin A3 intracellular region reveals an autoinhibited conformation through active site sequestration

He, H., Yang, T. Terman, J.R., Zhang, X. , Proc Natl Acad Sci USA , 2009; (In press)

Featured
Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface.

Zhang, X., Pickin K. P., Bose R., Jura N., Cole, P. A., and Kuriyan, J. , Nature , 2007; (450):741-744

Featured
An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor

Zhang, X., Gureasko, J., Shen, K., Cole, P. A., and Kuriyan, J. , Cell , 2006; (125):1137-1149

Featured
Structural basis for co-stimulation by the human CTLA-4/B7-2 complex

Schwartz, J. C.*, Zhang, X.*, Fedorov, A. A., Nathenson, S. G., and Almo, S. C. (*equal contributions) , Nature , 2001; (410):604-608

Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface.

Zhang, X., Pickin K. P., Bose R., Jura N., Cole, P. A., and Kuriyan, J. , Nature , November 2007; (450):741-744

Mechanism for activation of the EGF receptor catalytic domain by the juxtamembrane segment

Jura, N. Endres, N. F. Engel, K. Deindl, S. Das, R. Lamers, M. H. Wemmer, D. E. Zhang, X. Kuriyan, J. , Cell , 2009; (137):1293-1307

Crystal structure of the plexin A3 intracellular region reveals an autoinhibited conformation through active site sequestration

He, H., Yang, T. Terman, J.R., Zhang, X. , Proc Natl Acad Sci USA , 2009; (100):2586-2591

An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor.

Zhang, X., Gureasko, J., Shen, K., Cole, P. A., and Kuriyan, J. , Cell , 2006; (125):1137-1149

Honors/Awards

Virginia Murchison Linthicum Scholar in Medical Research

UT Southwestern Medical Center (2007)

Julius Marmur Research Award

Albert Einstein School of Medicine (2002)