Shwu-Yuan Wu, PhD

Assistant Professor
Simmons Comprehensive Cancer Center, Biochemistry

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

Office Phone: 214-648-4190
Office Fax: 214-648-7084

shwu-yuan.wu@utsouthwestern.edu

Education

Graduate SchoolUniversity of Rochester, Biochemistry (1993)
Graduate SchoolYang-Ming Medical College - China, Biochemistry (1986)

Research Interests

Chromatin and Epigenetics
Human Papillomaviruses
p53 Tumor Supressor Protein
Post-Translational Modifications
Transcription and Gene Regulation

Publications

Featured
Brd4 links chromatin targeting to HPV transcriptional silencing

Wu, S.-Y., A.Y. Lee, S.Y. Hou, J.K. Kemper, H. Erdjument-Bromage, P. Tempst, and C.-M. Chiang , Genes Dev. , 2006; (20):2383-2396

Featured
Human Mediator enhances activator-facilitated recruitment of RNA polymerase II and promoter recognition by TATA-binding protein (TBP) independently of TBP-associated factors

Wu, S.-Y., T. Zhou, and C.-M. Chiang , Mol. Cell. Biol. , 2003; (23):6229-6242

Featured
TATA-binding protein-associated factors enhance the recruitment of RNA polymerase II by transcriptional activators

Wu, S.-Y. and C.-M. Chiang , J. Biol. Chem. , 2001; (276):34235-34243

Featured
Isolation of mouse TFIID and functional characterization of TBP and TFIID in mediating estrogen receptor and chromatin transcription

Wu, S.-Y., M.C. Thomas, S.Y. Hou, V. Likhite, and C.-M. Chiang , J. Biol. Chem. , 1999; (274):23480-23490

Featured
TAFII-independent activation mediated by human TBP in the presence of the positive cofactor PC4

Wu, S.-Y., E. Kershnar, and C.-M. Chiang , EMBO J. , 1998; (17):4478-4490

The double bromodomain-containing chromatin adaptor Brd4 and transcriptional regulation

Wu, S.-Y. and C.-M. Chiang , J. Biol. Chem. , 2007; (282):13141-13145

CTCF interacts with and recruits the largest subunit of RNA polymerase II to CTCF target sites genome-wide

Chernukhin, I., S. Shamsuddin, S.Y. Kang, R. Bergstrom, Y.-W. Kwon, W. Yu, J. Whitehead, R. Mukhopadhyay, F. Docquier, D. Farrar, I. Morrison, M. Vigneron, S.-Y. Wu, C.-M. Chiang, D. Loukinov, V. Lobanenkov, and E. Klenova , Mol. Cell. Biol. , 2007; (27):1631-1648

Recruitment of TFIIH to the HIV LTR is a rate-limiting step in the emergency of HIV from latency

Kim, Y.K., C.F. Bourgeois, R. Pearson, M. Tyagi, M.J. West, J. Wong, S.-Y. Wu, C.-M. Chiang, and J. Karn , EMBO J. , 2006; (25):3596-3604

Dynamic localization of the human papillomavirus type 11 origin binding protein E2 through mitosis while in association with the spindle apparatus

Dao, L.D., A. Duffy, B.A. Van Tine, S.-Y. Wu, C.-M. Chiang, T.R. Broker, and L.T. Chow , J. Virol. , 2006; (80):4792-4800

SREBP-1c and Sp1 interact to regulate transcription of the gene for phosphoenolpyruvate carboxykinase (GTP) in the liver

Chakravarty, K., S.-Y. Wu, C.-M. Chiang, D. Samols, and R.W. Hanson , J. Biol. Chem. , 2004; (279):15385-15395

Honors/Awards

Postdoctoral Fellow

Aaron Diamond Foundation (1995)

Elon Huntington Hooker Graduate Fellowship

University of Rochester (1993)