Jennifer Kohler, PhD

Assistant Professor
Biochemistry
Graduate Program: Biological Chemistry

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

Office Phone: 214-648-0535
Office Fax: 214-648-8856

jennifer.kohler@utsouthwestern.edu

Education

Graduate SchoolYale University, Chemistry

Research Interests

carbohydrates
chemical biology
glycobiology
Golgi
membrane proteins

Publications

Featured
Metabolically incorporated photocrosslinking sialic acid covalently captures a ganglioside-protein complex

MR Bond, CM Whitman, & JJ Kohler , Molecular Biosystems , 2010; (6):1796-1799

Featured
A two-hybrid assay to study protein interactions within the secretory pathway

DH Dube, B Li, EJ Greenblatt, S Nimer, AK Raymond and JJ Kohler , PLoS ONE , 2010; (5):e15648

Featured
Photoactivatable crosslinking sugars for capturing glycoprotein interactions

Y Tanaka and JJ Kohler , J. Amer. Chem. Soc. , 2008; (130):3278-3279

Featured
Regulating cell surface glycosylation by small molecule control of enzyme localization

JJ Kohler and CR Bertozzi , Chemistry and Biology , 2003; (10):1303-1311

Featured
Enhanced DNA specificity achieved by sequential binding of protein monomers

JJ Kohler, SJ Metallo, TL Schneider, and A Schepartz , Proc. Natl. Acad. Sci. USA , 1999; (96):11735-11739

Metabolic crosstalk allows labeling of human O-linked β-N-acetylglucosamine-modified proteins via the N-acetylgalactosamine salvage pathway

M Boyce, IS Carrico, AS Ganguli, S-H Yu, MJ Hangauer, SC Hubbard, JJ Kohler & CR Bertozzi , Proc. Natl. Acad. Sci. USA , 2011; (108):3141-3146

Modified GM3 gangliosides produced by metabolic oligosaccharide engineering

CM Whitman, F Yang, & JJ Kohler , Bioorg. Med. Chem. Lett. , 2011; (21):5006-5010

A shift for the O-GlcNAc paradigm

JJ Kohler , Nat. Chem. Biol. , 2010; (6):634-635

Metabolic labeling of glycoconjugates with photocrosslinking sugars

S-H Yu, MR Bond, CM Whitman, and JJ Kohler , Methods in Enzymology , 2010; (478):541-562

Metabolism of diazirine-modified N-acetylmannosamine analogs to photocrosslinking sialosides

MR Bond, H Zhang, J Kim, S-H Yu, F Yang, SM Patrie, JJ Kohler , Bioconjugate Chemistry , ; :in press

Honors/Awards

Research Fellowship

Alfred P. Sloan Foundation (2009)

Basil O’Connor Starter Scholar Research Award

March of Dimes (2007)

CAREER Award

National Science Foundation (2007)

New Faculty Award

Camille and Henry Dreyfus Foundation (2005)