Cheng-Ming Chiang, PhD

Professor
Simmons Comprehensive Cancer Center, Biochemistry, Pharmacology
Graduate Program: Cell Regulation
Molecular Microbiology

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

Office Phone: 214-645-6128
Office Fax: 214-645-6347

cchia1@mednet.swmed.edu

Biography

Cheng-Ming Chiang was born in Taipei, Taiwan in 1961. He received his BS from the Department of Agricultural Chemistry, National Taiwan University, in 1984, and his PhD from the Department of Biochemistry, University of Rochester, in 1991. His doctoral dissertation was supervised by Professors Louise Chow and Thomas Broker. After finishing his postdoctoral training with Professor Robert Roeder at Rockefeller University, he took a faculty position in the Department of Biochemistry at University of Illinois, Urbana-Champaign in 1995. In 2000, he moved to Department of Biochemistry at Case Western Reserve University as tenured Associate Professor.

Dr. Chiang accepted a Professorship at UT Southwestern and relocated his laboratory to UT Southwestern in July 2007.

Dr. Chiang is a 1996 Pew Scholar and has been an editorial board member of the Journal of Biological Chemistry and Faculty of 1000 since 2003. He has been a regular member for American Cancer Society Genetic/DNA Mechanisms in Cancer, National Institutes of Health Virology B, and Human Frontier Science Program study sections. His research interests span transcription, chromatin, gene regulation, and virology.

Education

Graduate SchoolUniversity of Rochester, Biochemistry
UndergraduateNational Taiwan University, Chemistry

Research Interests

Chromatin Transcription and Posttranslational Modification
Gene Regulation in Human Papillomaviruses (HPVs)
Gene Regulation on TATA-Less Promoters
Mechanisms of Nuclear Hormone Receptor Function
Role of Human General Transcription Factors and Cofactors in Eukaryotic Transcription

Publications

Featured
Crosstalk between acetylation and sumoylation in regulating p53-dependent chromatin transcription and DNA binding

Wu, S.-Y. and C.-M. Chiang , EMBO J. , 2009; (28):1246-1259

Featured
Brd4 links chromatin targeting to HPV transcriptional silencing

Wu, S.-Y., A.Y. Lee, S.Y. Hou, J.K. Kemper, H. Erdjument-Bromage, P. Tempst, and C.-M. Chiang , Genes & Development , 2006; (20):2383-2396

Featured
E6 oncoprotein represses p53-dependent gene activation via inhibition of protein acetylation independently of inducing p53 degradation

Thomas, M.C. and C.-M. Chiang , Molecular Cell , 2005; (17):251-264

Featured
Human Mediator enhances activator-facilitated recruitment of RNA polymerase II and promoter recognition by TATA-binding protein (TBP) independently of TBP-associated factors

Wu, S.-Y., T. Zhou, and C.-M. Chiang , Mol. Cell. Biol. , 2003; (23):6229-6242

Chromatin adaptor Brd4 modulates E2 transcription activity and protein stability

Lee, A-Y. and C.-M. Chiang , J. Biol. Chem. , 2009; (284):2778-2786

Crosstalk between acetylation and sumoylation in regulating p53-dependent chromatin transcription and DNA binding

Wu, S.-Y. and C.-M. Chiang , EMBO J. , 2009; (28):1246-1259

One-step affinity tag purification of full-length recombinant human AP-1 complexes from bacterial inclusion bodies using a polycistronic expression system

Wang, W.-M., A-Y. Lee, and C.-M. Chiang , Protein Expr. Purif. , 2008; (59):144-152

The double bromodomain-containing chromatin adaptor Brd4 and transcriptional regulation

Wu, S.-Y. and C.-M. Chiang , J. Biol. Chem. , 2007; (282):13141-13145

The general transcription machinery and general cofactors

Thomas, M.C. and C.-M. Chiang , Critical Reviews in Biochemistry and Molecular Biology , 2006; (41):105-178

Honors/Awards

Mt. Sinai Health Care Foundation Scholar

Case Western Reserve University (2000)

Pew Scholar in the Biomedical Sciences

Pew Charitable Trust (1996)

Postdoctoral Fellow

Helen Hay Whitney Foundation (1993)

Postdoctoral Fellow

Aaron Diamond Foundation (1993)

The Wallace O. Fenn Award

University of Rochester (1991)