John MacMillan, PhD

Assistant Professor
Endowed Title: Chilton/Bell Scholar in Biochemistry Research 2007-2011
Biochemistry
Graduate Program: Biological Chemistry

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

Office Phone: 214-648-3338
Office Fax: 214-648-8856

john.macmillan@utsouthwestern.edu

Biography

Post-doc: Scripps Institution of Oceanography

Ph.D.: University of California, Davis (Chemistry)

B.Sc.: University of Iowa (Chemistry) 

Education

Graduate SchoolUniversity of California-Davis (2004)

Research Interests

analytical chemistry
marine microbiology
natural products
organic chemistry

Publications

Featured
Towards patient-based cancer therapeutics.

Schreiber SL, Shamji AF, Clemons PA, Hon C, Koehler AN, Munoz B, Palmer M, Stern AM, Wagner BK, Powers S, Lowe SW, Guo X, Krasnitz A, Sawey ET, Sordella R, Stein L, Trotman LC, Califano A, Dalla-Favera R, Ferrando A, Iavarone A, Pasqualucci L, Silva J, Stockwell BR, Hahn WC, Chin L, DePinho RA, Boehm JS, Gopal S, Huang A, Root DE, Weir BA, Gerhard DS, Zenklusen JC, Roth MG, White MA, Minna JD, MacMillan JB, Posner BA, Nature biotechnology, 2010 Sep; 28 (9):904-6

Featured
Deconvolution of complex NMR spectra in small molecules by multi frequency homonuclear decoupling (MDEC).

Espindola AP, Crouch R, DeBergh JR, Ready JM, MacMillan JB, Journal of the American Chemical Society, 2009 Nov; 131 (44):15994-5

Featured
Lodopyridone, a structurally unprecedented alkaloid from a marine actinomycete.

Maloney KN, Macmillan JB, Kauffman CA, Jensen PR, Dipasquale AG, Rheingold AL, Fenical W, Organic letters, 2009 Dec; 11 (23):5422-4

Featured
RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway.

Chiu YH, Macmillan JB, Chen ZJ, Cell, 2009 Aug; 138 (3):576-91

Featured
Ammosamides A and B target myosin.

Hughes CC, MacMillan JB, GaudĂȘncio SP, Fenical W, La Clair JJ, Angewandte Chemie (International ed. in English), 2009 ; 48 (4):728-32

Featured
The ammosamides: structures of cell cycle modulators from a marine-derived Streptomyces species.

Hughes CC, MacMillan JB, GaudĂȘncio SP, Jensen PR, Fenical W, Angewandte Chemie (International ed. in English), 2009 ; 48 (4):725-7

Featured
An N-acyl homolog of mycothiol is produced in marine actinomycetes.

Newton GL, Jensen PR, Macmillan JB, Fenical W, Fahey RC, Archives of microbiology, 2008 Nov; 190 (5):547-57

Featured
Phorbasides A-E, cytotoxic chlorocyclopropane macrolide glycosides from the marine sponge Phorbas sp. CD determination of C-methyl sugar configurations.

MacMillan JB, Xiong-Zhou G, Skepper CK, Molinski TF, The Journal of organic chemistry, 2008 May; 73 (10):3699-706

Featured
Chlorocyclopropane macrolides from the marine sponge Phorbas sp. assignment of the configurations of phorbasides A and B by quantitative CD.

Skepper CK, Macmillan JB, Zhou GX, Masuno MN, Molinski TF, Journal of the American Chemical Society, 2007 Apr; 129 (14):4150-1

Featured
Chlorocyclopropane Macrolides from the Marine Sponge Phorbas sp. Assignment of Configurations of Phorbasides A and B by Quantitative CD

MacMillan, J.B.; Skepper, C.; Zhou, G.Z.; Skepper, C.; Masuno, M.N.; Molinski, T.F. , J. Am. Chem. Soc , 2007;

Honors/Awards

Chilton/Bell Scholar in Biochemistry