Todd Eagar, PhD

Assistant Professor
Pathology, Immunology
Graduate Program: Immunology
Integrative Biology
Download Curriculum Vitae

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

Office Phone: 214-648-3857

todd.eagar@utsouthwestern.edu

Education

Graduate SchoolNorthwestern University (2001)

Research Interests

Autoimmune disease (Multiple Sclerosis)
Immunology (T cell and B cell responses)
Neuroimmunology (Multiple Sclerosis, Alzheimer's Disease)
Transplant Immunology (Histocompatibility and Immunogenetics)
Transplantation (Bone marrow and Solid organ transplants)

Publications

CTLA-4 regulates expansion and differentiation of Th1 cells following induction of peripheral T cell tolerance.

11. Eagar TN, Turley DM, Padilla J, Karandikar NJ, Tan L, Bluestone JA, Miller SD , Journal of Immunology , Summer 2004; (172):7442-7450.

Notch 1 signaling regulates peripheral T cell activation.

10. Eagar TN, Tang Q, Wolfe M, He Y, Pear WS, Bluestone JA , Immunity , April 2004; (20):407-15

Parkinson's Disease: A Role for the Immune System.

German DC, Eagar T, Sonsalla PK, Current molecular pharmacology, 2011 Jun;

Lymph node-derived donor encephalitogenic CD4+ T cells in C57BL/6 mice adoptive transfer experimental autoimmune encephalomyelitis highly express GM-CSF and T-bet.

Cravens PD, Hussain RZ, Zacharias TE, Ben LH, Hernden E, Vinnakota R, Lambracht-Washington D, Nessler S, Zamvil SS, Eagar TN, Stuve O, Journal of neuroinflammation, 2011 Jun; 8 (1):73

DNA Immunization Against Amyloid beta 42 has High Potential as Safe Therapy for Alzheimer's Disease as it Diminishes Antigen-Specific Th1 and Th17 Cell Proliferation.

Lambracht-Washington D, Qu BX, Fu M, Anderson LD, Stüve O, Eagar TN, Rosenberg RN, Cellular and molecular neurobiology, 2011 Aug; 31 (6):867-74

Rituximab therapy reduces organ-specific T cell responses and ameliorates experimental autoimmune encephalomyelitis.

Monson NL, Cravens P, Hussain R, Harp CT, Cummings M, de Pilar Martin M, Ben LH, Do J, Lyons JA, Lovette-Racke A, Cross AH, Racke MK, Stüve O, Shlomchik M, Eagar TN, PloS one, 2011 ; 6 (2):e17103

Reversible alopecia associated with glatiramer acetate.

Pacheco MF, Jacobe H, Eagar TN, Stüve O, Archives of neurology, 2010 Sep; 67 (9):1154

Memory B cells from a subset of treatment-naïve relapsing-remitting multiple sclerosis patients elicit CD4(+) T-cell proliferation and IFN-? production in response to myelin basic protein and myelin oligodendrocyte glycoprotein.

Harp CT, Ireland S, Davis LS, Remington G, Cassidy B, Cravens PD, Stuve O, Lovett-Racke AE, Eagar TN, Greenberg BM, Racke MK, Cowell LG, Karandikar NJ, Frohman EM, Monson NL, European journal of immunology, 2010 Oct; 40 (10):2942-56

Translational research in neurology and neuroscience 2010: multiple sclerosis.

Stüve O, Kieseier BC, Hemmer B, Hartung HP, Awad A, Frohman EM, Greenberg BM, Racke MK, Zamvil SS, Phillips JT, Gold R, Chan A, Zettl U, Milo R, Marder E, Khan O, Eagar TN, Archives of neurology, 2010 Nov; 67 (11):1307-15

Analysis of three plasmid systems for use in DNA A beta 42 immunization as therapy for Alzheimer's disease.

Qu BX, Lambracht-Washington D, Fu M, Eagar TN, Stüve O, Rosenberg RN, Vaccine, 2010 Jul; 28 (32):5280-7

Books

Clinical Immunology Principles and Practice Second Edition (11. Eagar TN, Tompkins SM and Miller SD. Helper T cell Subsets and Control of the Inflammatory Response)

Eagar TN, Tompkins SM and Miller SD., Mosby2001

Clinical Immunology Principles and Practice Third Edition (Helper T cell Subsets and Control of the Inflammatory Response.)

Eagar TN, and Miller SD, Mosby International2008