Pier Scaglioni, MD

Assistant Professor
Internal Medicine
Graduate Program: Cancer Biology

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

pier.scaglioni@utsouthwestern.edu

To make an appointment, call 214-645-8300.

Biography

Dr. Pier Paolo Scaglioni received his M.D. degree in 1989 from the University of Modena, Italy. After completing a residency in Internal Medicine at the University of Modena in, in 1993 he joined as a post-doctoral associate the laboratory of Dr. Jack R. Wands at the Massachusetts General Hospital Cancer Center where he studied the mechanisms leading to hepatitis B virus induced liver disease. Subsequently, Dr. Scaglioni the residency program in Internal Medicine at the Albert Einstein Medical College (1998-2001) and a Fellowship in Hematology/Oncology at the Memorial Sloan-Kettering Cancer Center (2001-2005). During oncology training he focused his interests on hemopoietic malignancies and in 2002 he joined the laboratory of Dr. Pier Paolo Pandolfi where he initiated studies to elucidate the mechanisms controlling the Promyelocytic Leukemia gene tumor suppressive function. In 2005 Dr. Scaglioni joined as a Faculty Member the Hematology Service of Memorial-Sloan Kettering Cancer Center. In October 2006, Dr. Scaglioni became an Assistant Professor in the Department of Medicine, Division of Hematology/Oncology of the UT Southwestern Medical Center. He is leading the Cancer Signaling Laboratory of the Simmons Cancer Center while maintaining a limited oncology practice in the Bone Marrow Transplant program at UTSW. Dr. Scaglioni has received several Awards including the ASCO Young Investigator Award, the CALGB Oncology Fellows Award, the Michael and Ethel L. Cohen Fellowship and the Charles A. Dana Clinical Scholarship. Dr. Scaglioni enjoys outdoor activities and spending time with his wife and daughter.

Education

FellowshipMemorial Sloan Kettering Cancer Center, Internal Medicine (2004)
Internship/ResidencyMontefiore Medical Center Medical Staff Services, Internal Medicine (2001)
Medical SchoolUniversita' Degli Studi Di Modena (1989)

Publications

In vivo analysis of the role of aberrant histone deacetylase recruitment and RARalpha blocade in the pathogenesis of acute promyelocytic leukemia

H. Matsushita, P.P. Scaglioni, M. Bhaumik, E.M. Rego, L.F. Cai, Hayato Miyachi, A. Kakizuka, W.H. Miller, P.P. Pandolfi , J Exp Med , 2006; (17):821-828

Identification of a tumor suppressor network opposing nuclear Akt function

L.C. Trotman, A. Alimonti, P.P. Scaglioni, J.A. Koutcher, C. Cordon-cardo, P.P. Pandolfi , Nature , 2006; (25):523-527

A CK2-dependent pathway for PML degradation upon cellular and oncogenic stress

P.P. Scaglioni, T. Yung, L. F. Cai, H. Erdjument-Bromage, P. Tempst, J. Teruya-Feldstein, P.P. Pandolfi , Cell , 2006; (126):269-83

PML regulates p53 stability by sequestering Mdm2 to the nucleolus

R. Bernardi, P.P. Scaglioni, S. Bergmann, H.F. Horn, K.H. Vousden and P.P Pandolfi , Nature Cell Biology , 2004; (6):665-672

Taking apart a cancer protein

P.P. Scaglioni and P.p. Pandolfi , Nature , 2003; (426):512-13

Honors/Awards

ASH

Travel Award (2004)

Charles A. Dana Fellow

Clinical Scholars Training Program in Biomedical Research (2004)

ASCO

Young Investigator Award (2003)

CALGB

Oncology Fellows Award (2003)

Montefiore Medical Center/A. Einstein College of Medicine

Citation in Recognition as an outstanding House Officer (2001)