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Tawanda Gumbo, MD
Contact Information
UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390
tawanda.gumbo@utsouthwestern.edu
To make an appointment, call 214-645-8300.
Biography
Tawanda Gumbo, M.D., was born in Zimbabwe, and attended the University of Zimbabwe Medical School. From 1993 to 1996 he was an intern and resident in Internal Medicine/International Health Tract at Case Western Reserve University at MetroHealth Medical Center in Cleveland, Ohio, and from 1996-1999 he was a fellow in Infectious Diseases at the Cleveland Clinic Foundation in Cleveland, Ohio. In 2001 he joined the Albany Medical College and the Ordway Research Institute in Albany, New York, where he worked on establishing the mouse model of disseminated Candida glabrata and the hollow fiber model of tuberculosis in the laboratory of George Drusano, MD who further mentored him in pharmacology of antimicrobial agents, advanced mathematical modeling and clinical trial simulations. While there he published a poetry book "Songs for flame lily" (2005) and a political novel "The Fire Inside" (2002). In 2006 he moved to the University of Texas Southwestern Medical Center at Dallas and established his laboratory in the Division of Infectious Diseases. The laboratory has elucidated the role of efflux pumps in survival of Mycobacterium tuberculosis and examined molecules that could exploit these to enhance antituberculosis therapy. Work has also included integrating pharmacogenomics into clinical trial simulations for antituberculosis drugs with multimodal systemic elimination, establishment of a mathematical model for the relationship between antimicrobial drug exposure and resistance emergence, and recently the establishment of new susceptibility breakpoints of first-line antituberculosis drugs. In 2007 he received the NIH Director’s New Innovator Award to focus on efflux pump inhibition to accelerate therapy and reduce duration of antituberculosis therapy. In 2008 he was promoted to Associate Professor. In 2009 he was made a Mellon Visiting Scholar at the University of Cape Town in South Africa. He is also a contributor of two chapters in the 12th edition of the pre-eminent pharmacology text "Goodman and Gilman’s The Pharmacological Basis of Therapeutics" namely, "Principles of Chemotherapy of Infectious Diseases" and "Chemotherapy of Tuberculosis, Mycobacterium avium Complex, Leprosy."
Education
| Fellowship | Cleveland Clinic Foundation, Infectious Disease (1999) |
| Internship/Residency | Metrohealth Medical Center, Internal Medicine (1996) |
| Medical School | University of Zimbabwe (1991) |
Research Interests
Publications
Gumbo T, Louie A, Liu W, Brown D, Ambrose P, Bhavnani SM, Drusano GL. , Antimicrobial Agents and Chemotherapy , July 2007; (51 (7)):2329-2336
Gumbo, T , Current Opinion in Drug Discovery and Development , January 2008; (11 (1)):32-42
Ambrose PG, Bhavnani SM, Rubino CM, Louie A, Gumbo T, Forrest A, Drusano GL. , Clinical Infectious Diseases , January 2007; (44):79-86
Gumbo T, Drusano GL, Liu W, Fregeau C, Hsu V, Louie A. , Antimicrobial Agents and Chemotherapy , 2007; (51):968-974
Gumbo T, Drusano GL, Liu W, Ma L, Deziel MR, Drusano MF, Louie A , Antimicrobial Agents and Chemotherapy , 2006; (50 (11)):3695-700
Deshpande D, Srivastava S, Meek C, Leff R, Gumbo T , Antimicrobial Agents and Chemotherapy , May 2010; (54 (5)):1728-1733
Deshpande D, Srivastava S, Meek C, Leff R, Hall GS, Gumbo T. , Antimicrobial Agents and Chemotherapy , June 2010; (54 (6))
Gumbo T, Siyambalapitiyage Dona CW, Meek C, Leff R , Antimicrobial Agents and Chemotherapy , August 2009; (8):3197-3204
Gumbo T , Antimicrobial Agents and Chemotherapy , April 2010; (54 (4)):1484-1491
Srivastava S, Musuka S, Sherman C, Meek C, Leff R, Gumbo T , Journal of Infectious Diseases , April 2010; (201 (8)):1225-1231
Related Links
Books
Tawanda Gumbo, The McGraw-Hill Companies, Inc2010
Tawanda Gumbo, The McGraw-Hill Companies, Inc2010
Tawanda Gumbo & John D. Cleary, American Society of Health-System Pharmacists (Bethesda, MD) 2010
Jotam Pasipanodya, Ronald Hall II, Tawanda Gumbo, Elsevier, Saunders (Philadelphia) 2010, 2011
Tawanda Gumbo, Fumiaki Ikeda, Arnold Louie, Informa Healthcare (New York, NY) 2007
Honors/Awards
University of Cape Town (2009)
National Institutes of Health (2007)
Australian Mathematics Competition for the Westpac Awards, Senior Division (1986)