Juan Pascual, MD, PhD

Assistant Professor
Neurology and Neurotherapeutics, Pediatrics, Physiology
Graduate Program: Integrative Biology
Neuroscience

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

juan.pascual@utsouthwestern.edu

To make an appointment, call 214-645-8300.

Biography

Juan M. Pascual holds appointments to the faculty of the Departments of Neurology and Neurotherapeutics, Physiology and Pediatrics and is Director of the Rare Brain Disorders Clinic and Laboratory. He is also a member of the Division of Pediatric Neurology, of the graduate programs in Neuroscience and Integrative Biology, and of the postgraduate clinical training programs in Neurology, Pediatric Neurology, Pediatrics and Medical Genetics.

Dr. Pascual received his M.D. degree from the Universidad de Granada, Spain (founded in 1526 by Emperor Charles V over the school established by the Nasrid Sultan of Granada in 1349). He received his Ph.D. degree in Molecular Physiology and Biophysics from Baylor College of Medicine in Houston, Texas. His postdoctoral research was conducted at the Center for Molecular Recognition, College of Physicians and Surgeons of Columbia University and, later, at the Colleen Giblin Research Laboratories for Pediatric Neurology at the same institution. He also obtained residency training in Pediatrics at Washington University School of Medicine- St. Louis Children’s Hospital and in Neurology and Pediatric Neurology at the Neurological Institute of New York- Columbia University Medical Center. He received certification in Neurology with Special Qualification in Child Neurology from the American Board of Psychiatry and Neurology.

As a clinician, he specializes in genetic and metabolic diseases of the nervous and neuromuscular systems of infants, children and adults with a particular emphasis on complex diagnostic problems, second opinions for patients visiting from the rest of the U.S. and abroad, and in pilot and national clinical trials. Dr. Pascual has special clinical research expertise in glucose metabolism, mitochondrial and unusual degenerative and multi-organ disorders.

As one of few pediatric neurologists in the nation who is also a laboratory scientist, Dr. Pascual is interested in the molecular mechanisms that cause inherited metabolic and excitability disorders using electrophysiology and nuclear magnetic resonance (MRI) both in human subjects and in models of human diseases. His laboratory is located in the newest biomedical research building (NL) at UT Southwestern and is an integral part of the Department of Neurology and Neurotherapeutics.

An avid reader, speaker and humanist, Dr. Pascual is also interested in metaphysics, epistemology and the philosophy of mind.

Education

ResidencyColumbia Presbyterian Medical Center - NY (2002)
InternshipWashington University St. Louis (1999)
Graduate SchoolBaylor College of Medicine (1995)
UniversityBaylor College of Medicine (1995)
UniversityUniversity of Missouri - Kansas City (1991)
Medical SchoolUniversidad de Granada (1990)

Research Interests

Brain metabolism
Functional brain imaging
Neural excitability: synaptic transmission
Neurogenetic disorders

Publications

Featured
2-hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated patients with gliomas.

Choi C, Ganji SK, Deberardinis RJ, Hatanpaa KJ, Rakheja D, Kovacs Z, Yang XL, Mashimo T, Raisanen JM, Marin-Valencia I, Pascual JM, Madden CJ, Mickey BE, Malloy CM, Bachoo RM, Maher EA, Nature medicine, 2012 Jan;

Featured
High-resolution detection of (13)C multiplets from the conscious mouse brain by ex vivo NMR spectroscopy.

Marin-Valencia I, Good LB, Ma Q, Jeffrey FM, Malloy CR, Pascual JM, Journal of neuroscience methods, 2011 Sep;

Featured
Animal models of the human mind: Is there anything it is like to be autistic?

Pascual JM, Neuroscience letters, 2011 Oct;

Natural history of MELAS associated with mitochondrial DNA m.3243A>G genotype.

Kaufmann P, Engelstad K, Wei Y, Kulikova R, Oskoui M, Sproule DM, Battista V, Koenigsberger DY, Pascual JM, Shanske S, Sano M, Mao X, Hirano M, Shungu DC, Dimauro S, De Vivo DC, Neurology, 2011 Nov; 77 (22):1965-71

Cerebral folate deficiency syndromes in childhood: clinical, analytical, and etiologic aspects.

Pérez-Dueñas B, Ormazábal A, Toma C, Torrico B, Cormand B, Serrano M, Sierra C, De Grandis E, Marfa MP, García-Cazorla A, Campistol J, Pascual JM, Artuch R, Archives of neurology, 2011 May; 68 (5):615-21

Measurement of glycine in the human brain in vivo by (1) H-MRS at 3 T: application in brain tumors.

Choi C, Ganji SK, Deberardinis RJ, Dimitrov IE, Pascual JM, Bachoo R, Mickey BE, Malloy CR, Maher EA, Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, 2011 Mar; :609-18

Synaptic transporters are deceived if they think themselves free.

Pascual JM, Neuroscience letters, 2011 Jan; 487 (1):1-2

Pyruvate carboxylase deficiency: mechanisms, mimics and anaplerosis.

Marin-Valencia I, Roe CR, Pascual JM, Molecular genetics and metabolism, 2010 Sep; 101 (1):9-17

Diagnosis and management of Duchenne muscular dystrophy, part 1: diagnosis, and pharmacological and psychosocial management.

Bushby K, Finkel R, Birnkrant DJ, Case LE, Clemens PR, Cripe L, Kaul A, Kinnett K, McDonald C, Pandya S, Poysky J, Shapiro F, Tomezsko J, Constantin C, Lancet neurology, 2010 Jan; 9 (1)

Diagnosis and management of Duchenne muscular dystrophy, part 2: implementation of multidisciplinary care.

Bushby K, Finkel R, Birnkrant DJ, Case LE, Clemens PR, Cripe L, Kaul A, Kinnett K, McDonald C, Pandya S, Poysky J, Shapiro F, Tomezsko J, Constantin C, Lancet neurology, 2010 Feb; 9 (2)

Books

Merritt's Neurology, 11th and 12th edition (Floppy infant syndrome)

Pascual JM, De Vivo DC, Lippincott, Williams & Wilkins2009

On Call Neurology, 2nd and 3rd edition (Pediatric neurology)

Pascual JM, W.B. Saunders2007

Merritt's Neurology, 11th and 12th edition (Glucose transporter type 1 deficiency syndrome)

De Vivo DC, Pascual JM, Wang D, Lippincott, Williams & Wilkins2009

The Molecular and Genetic Basis of Neurologic and Psychiatric Disease, 2nd and 3rd edition (Disorders of glucose transport)

De Vivo DC, Wang D, Pascual JM, Butterworth-Heinemann2008

Molecular Neurology, 1st edition (Developmental Neurology: a molecular perspective)

Pascual JM, Academic Press2007

Molecular Neurology, 1st edition (Metabolic diseases of the nervous system)

Pascual JM, Academic Press2007

Molecular Neurology, 1st edition (Genetic disorders of neuromuscular development)

Pascual JM, Academic Press2007

Neurology and Clinical Neuroscience, 1st edition (Encephalopathies)

Pascual JM, Mosby Elsevier2007

National Organization for Rare Disorders' Guide to Rare Disorders (Glucose transporter 1 deficiency syndrome)

Pascual JM, K. Engelstad, D. Wang, D. C. De Vivo, Lippincott, Williams, and Wilkins2002

Encyclopedia of Neurological Sciences, 2nd edition (Kernicterus)

Pascual JM , In press

Toward a neuroethics of self and other: neuroscience, neurotechnology and the enigma of mind (The Can't and Don't of Psychopathy: Neuroimaging Technologies, Psychopaths and Criminal Responsibility)

Jotterand F, Pascual JM, Sadler, JZ , Cambridge University PressIn press

Basic Neurochemistry, 7th and 8th edition (Disorders of Muscle Excitability)

Pascual JM, Elsevier2011

Rudolph's Pediatrics, 22nd edition (Disorders of the Krebs cycle and of pyruvate metabolism and transport)

Pascual JM, DiMauro S, McGraw-Hill2011

Honors/Awards

Elected member

Académie Européenne des Sciences, des Arts et des Lettres (2010)

Miembro correspondiente

Real Academia de Bellas Artes de San Telmo (2010)

Young Investigator Award

Neurobiology of Disease in Children (2009)

Miembro correspondiente

Real Academia Española (2004)

Miembro de número

Academia Norteamericana de la Lengua Española (2004)