D Gomika Udugamasooriya, PhD

Assistant Professor
Advanced Imaging Research Center, Biochemistry
Graduate Program: Biological Chemistry

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

Office Phone: 214-645-7066
Office Fax: 214-645-2744

gomika.udugama@utsouthwestern.edu

Education

Graduate SchoolWayne State University, Biochemistry (2006)
UndergraduateUniversity of Colombo, Sri Lanka, Chemistry (1999)

Research Interests

Cancer therapy-diagnostic tool development - "Theranostics"
Combinatorial synthesis and cell screen
Novel contrast agent development
Peptidomimetics (in particular peptoid) development
Personalized medicine

Publications

Featured
On-Bead Combinatorial Synthesis and Imaging of Chemical Exchange Saturation Transfer Magnetic Resonance Imaging Agents To Identify Factors That Influence Water Exchange

Napolitano, R.; Soesbe, T.C.; De Leon-Rodriguez, L.M.; Sherry, A. D.; Udugamasooriya, D.G. , J. Amer. Chem. Soc. , 2011; 133

Featured
Development of Homo- and Hetero-Multimers of Lung Cancer Specific Peptoids

Hooks, J.C., Matharage, J.P., Udugamasooriya, D.G., , Biopolymers-Peptide Science , 2011; 96 (5)

Featured
Potent and Selective Photo-inactivation of Proteins With Peptoid-Ruthenium Conjugates

Lee, J.; Udugamasooriya, D.G.; Lim, H.S.; Kodadek, T.; , Nature Chemical Biology , 2010; (6):258-260

Featured
MRI detection of VEGFR2 in vivo using a low molecular weight peptoid-(Gd)8-dendron for targeting

De Leon Rodriguez, L. M.; Lubag, A.; Udugamasooriya, D.G.; Sun, X.; Kodadek,T.; Sherry, A.D , J. Amer. Chem. Soc. , 2010; (132(37)):12829-31

Featured
Isolation of Antagonists of Antigen-Specific Autoimmune T Cell Proliferation

Gocke, A.; Udugamasooriya, D.G.; Archer, C; Lee, J.; Kodadek, T. , Chemistry and Biology , 2009; (16(11)):1133‐9

Featured
GIPC/Synectin as a New Target in Pancreatic Cancer Treatment

Muders, M.H.; Wang, L., Dutta; S.K., Wang, E.; Ikeda, Y.; Udugamasooriya; D.G.; Memic, A.; Rupasinghe, C.; Baretton, G.; Datta, D.; Simons, M.; Spaller, M.R.; Mukhopadhyay, D.; , Clinical Cancer Research , 2009; (15(12)):4095-103

Featured
Conformational Constraint in Protein Ligand Design and the Inconsistency of Binding Entropy

Udugamasooriya, D.G.; Spaller, M.R. , Biopolymers , 2008; (89(8)):653-667

Featured
A Peptoid Antibody Surrogate That Antagonizes VEGF-VEGF Receptor 2 Interaction

Udugamasooriya, D.G.; Dineen, S.P.; Brekken, R.A.; Kodadek T.; , J. Amer. Chem. Soc. , 2008; (130):5744-5752

Featured
The Pharmacophore of a Peptoid VEGF Receptor 2 Antagonist Includes Both Side Chain and Main Chain Residues

Udugamasooriya, D.G.; Dunham, G.; Ritchie, C.; Brekken, R.A.; Kodadek, T.; , Bioorganic & Medicinal Chemistry Lett. , 2008; (18(22)):5892-5894

Featured
A Parallel Chemistry Approach to Organic-Modified Peptide Ligands for PDZ Domain Proteins: A Synthetic, Thermodynamic and Structural Investigation

Udugamasooriya, D.G.; Sharma, S.C.; Spaller, M.R.; , ChemBiochem , 2008; (9(10)):1587-1589

Honors/Awards

SPORE Career Development Award

(2010)

Professional Associations/Affiliations

Phi Lambda Upsilon - Alpha Psi chapter (Honorary Chemical Society)

The American Chemical Society