Joel Elmquist, DVM, PhD

Professor
Endowed Title: Maclin Family Professorship in Medical Science, in Honor of Dr. Roy A. Brinkley
Carl H. Westcott Distinguished Chair in Medical Research
Internal Medicine, Psychiatry, Pharmacology
Graduate Program: Integrative Biology
Neuroscience

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

joel.elmquist@utsouthwestern.edu

Education

Graduate SchoolIowa State University (1993)
Graduate SchoolIowa State University (1992)

Research Interests

Body Weight Homeostasis
Central Autonomic Control
Diabetes and Glucose Homeostasis
Neurobiology and Neuroanatomy of the Hypothalamus

Publications

Induction of leptin resistance by activation of cAMP-Epac signaling.

Fukuda M, Williams KW, Gautron L, Elmquist JK, Cell metabolism, 2011 Mar; 13 (3):331-9

Steroidogenic factor 1 directs programs regulating diet-induced thermogenesis and leptin action in the ventral medial hypothalamic nucleus.

Kim KW, Zhao L, Donato J, Kohno D, Xu Y, Elias CF, Lee C, Parker KL, Elmquist JK, Proceedings of the National Academy of Sciences of the United States of America, 2011 Jun; 108 (26):10673-8

Melanocortin-4 receptors expressed by cholinergic neurons regulate energy balance and glucose homeostasis.

Rossi J, Balthasar N, Olson D, Scott M, Berglund E, Lee CE, Choi MJ, Lauzon D, Lowell BB, Elmquist JK, Cell metabolism, 2011 Feb; 13 (2):195-204

Serotonin 2C receptor activates a distinct population of arcuate pro-opiomelanocortin neurons via TRPC channels.

Sohn JW, Xu Y, Jones JE, Wickman K, Williams KW, Elmquist JK, Neuron, 2011 Aug; 71 (3):488-97

5-HT2CRs expressed by pro-opiomelanocortin neurons regulate insulin sensitivity in liver.

Xu Y, Berglund ED, Sohn JW, Holland WL, Chuang JC, Fukuda M, Rossi J, Williams KW, Jones JE, Zigman JM, Lowell BB, Scherer PE, Elmquist JK, Nature neuroscience, 2010 Dec; 13 (12):1457-9

Direct insulin and leptin action on pro-opiomelanocortin neurons is required for normal glucose homeostasis and fertility.

Hill JW, Elias CF, Fukuda M, Williams KW, Berglund ED, Holland WL, Cho YR, Chuang JC, Xu Y, Choi M, Lauzon D, Lee CE, Coppari R, Richardson JA, Zigman JM, Chua S, Scherer PE, Lowell BB, Brüning JC, Elmquist JK, Cell metabolism, 2010 Apr; 11 (4):286-97

The hypothalamic arcuate nucleus: a key site for mediating leptin's effects on glucose homeostasis and locomotor activity.

Coppari R, Ichinose M, Lee CE, Pullen AE, Kenny CD, McGovern RA, Tang V, Liu SM, Ludwig T, Chua SC, Lowell BB, Elmquist JK, Cell metabolism, 2005 Jan; 1 (1):63-72

Activation of central melanocortin pathways by fenfluramine.

Heisler LK, Cowley MA, Tecott LH, Fan W, Low MJ, Smart JL, Rubinstein M, Tatro JB, Marcus JN, Holstege H, Lee CE, Cone RD, Elmquist JK, Science (New York, N.Y.), 2002 Jul; 297 (5581):609-11

Honors/Awards

Ernst Oppenheimer Award, The Endocrine Society

(2008)

Iowa State University Excellence in Research Award

(1993)