Chin-Rang Yang, PhD

Assistant Professor
Simmons Comprehensive Cancer Center, Radiation Oncology

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

Office Phone: 214-648-4190
Office Fax: 214-648-7084

chinrang.yang@utsouthwestern.edu

Biography

Dr. Chin-Rang Yang was born in Taiwan in 1966. He received his Bachelor of Science in Medical Technology from National Taiwan University. He came to the United States in 1992 and received his PhD in Developmental Biology & Human Oncology from the University of Wisconsin-Madison in 1998. His thesis focused on the DNA repair mechanism in cancer cells following radiation treatment. During his postdoctoral training at the University of Rochester, Dr. Yang became interested in Genomics and Bioinformatics research. He went back to school and received his Master’s degree in Information Technology; he then joined the Institute for Genomics and Bioinformatics at the University of California-Irvine for his second postdoctoral training in Systems Biology.

By combining his two academic backgrounds in biology and computer science, Dr. Yang developed the novel non-linear, enzyme-centric technique for mathematical modeling and the analysis of complex biological networks.

In 2005, Dr. Yang was appointed Assistant Professor at the Simmons Comprehensive Cancer Center, UT Southwestern. He is extending his research into Systems Biology in Cancer and participates in Bioinformatics research at the Cancer Center.

 

Education

Graduate SchoolUniversity of Wisconsin-Madison (1998)

Research Interests

Bioinformatics
DNA Microarray Analysis
Non-linear Dynamics of Biological Networks
Systems Biology

Publications

Featured
Nuclear apoJ/XIP8, an X-ray-inducible Ku70-binding Protein That Controls Radiosensitivity.

Yang C-R, Leskov K, Hosley-Eberlein K, Criswell T, Pink JJ, Kinsella TJ, Boothman DA. , Proc. Natl. Acad. Sci. , 2000; (97(11)):5907-5912

Featured
Isolation of Ku70-Binding Proteins (KUBs).

Yang, C-R., Yeh, S., Leskov K., Odegaard E., Hsu, H.L., Chang, C., Kinsella, T.J., Chen, D.J., and Boothman, D.A. , Nucleic Acids Research , 1999; (27(10)):2165-2174

The Generalized Monod, Wyman, Changeux Model for Mathematical Modeling of Metabolic Enzymes with Allosteric Regulation.

Yang, C-R, Najdi, T. S., Shapiro, B. E., Hatfield, G. W. and Eric D. Mjolsness. , Journal of Bioinformatics and Computational Biology , June 2006; (in press)

An enzyme mechanism language for the mathematical modeling of metabolic pathways.

Yang, C-R., Shapiro, B. E., Mjolsness, E. D., and Hatfield, G. W. , Bioinformatics , 2005; (21):774-780

A mathematical model for the branched chain amino acid biosynthetic pathways of Escherichia coli K12.

Yang, C-R., Shapiro, B. E., Hung, S-P., Mjolsness, E. D., and Hatfield, G. W. , J. Biol. Chem. , 2005; (280(12)):11224-11232

Honors/Awards

Breast Cancer Research Concept Award

Department of Defense, USA. (2000)

Pilot Research Award

Rochester Area Foundation, Rochester, NY (2000)

Young Investigator Travel Award

The 51st Annual Symposium on Fundamental Cancer Research, M.D. Anderson Cancer Center, Houston, TX (1998)

Hoffmann-La Roche Travel Award

The 84th Annual American Association for Cancer Research (AACR) Meeting, Wash., D.C. (1996)

Professional Associations/Affiliations

American Association for Cancer Research (AACR)

Institute of Electrical and Electronics Engineers (IEEE) Computer Society