Elisabeth Martinez, PhD

Assistant Professor
Pharmacology
Graduate Program: Cancer Biology

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

Office Phone: 214-648-5150
Office Fax: 214-645-5969

elisabeth.martinez@utsouthwestern.edu

Biography

POSITIONS:

1993-1994 Undergraduate Research Assistant, Department of Chemistry, Boston College, Newton, MA. Supervisor: Mary Roberts, PhD

1994-1996 Research Assistant, Department of Biochemistry and Molecular Biology, Georgetown University Medical Center, Washington DC. Supervisor: Mark Danielsen, PhD

1996-2002 Graduate Student Research Fellow, Department of Biochemistry and Molecular Biology, Georgetown University Medical Center, Washington, DC. Supervisor/mentor: Mark Danielsen, PhD

2002-2005 Postdoctoral Fellow, Laboratory of Receptor Biology and Gene Expression National Cancer Institute, NIH, Bethesda, MD. Supervisor: Gordon L. Hager, PhD

2005- 2009 Instructor, Department of Pharmacology, UT Southwestern.

Sept. 2009 -present Assistant Professor, Department of Pharmacology, UT Southwestern.

Education

Graduate SchoolGeorgetown University (2002)

Research Interests

Deregulation of transcriptional pathways in cancer
Drug discovery
Epigenetic control of gene expression
Novel therapeutics for gene expression disorders including cancer
The role of Jumonji histone demethylases in cancer
Transcriptional regulation by nuclear receptors

Publications

Featured
Identification of four potential epigenetic modulators from the NCI structural diversity library using a cell-based assay.

Best AM, Chang J, Dull AB, Beutler JA, Martinez ED, Journal of biomedicine & biotechnology, 2011 ; 2011:868095

Featured
Expression profiling of nuclear receptors in the NCI60 cancer cell panel reveals receptor-drug and receptor-gene interactions.

Holbeck S, Chang J, Best AM, Bookout AL, Mangelsdorf DJ, Martinez ED, Molecular endocrinology (Baltimore, Md.), 2010 Jun; 24 (6):1287-96

Featured
Characterizing heterogeneous cellular responses to perturbations.

Slack MD, Martinez ED, Wu LF, Altschuler SJ, Proceedings of the National Academy of Sciences of the United States of America, 2008 Dec; 105 (49):19306-11

Featured
A quantitative high-throughput screen identifies potential epigenetic modulators of gene expression.

Johnson RL, Huang W, Jadhav A, Austin CP, Inglese J, Martinez ED, Analytical biochemistry, 2008 Apr; 375 (2):237-48

Featured
Falling off the academic bandwagon. Women are more likely to quit at the postdoc to principal investigator transition.

Martinez ED, Botos J, Dohoney KM, Geiman TM, Kolla SS, Olivera A, Qiu Y, Rayasam GV, Stavreva DA, Cohen-Fix O, EMBO reports, 2007 Nov; 8 (11):977-81

Featured
HDAC1 acetylation is linked to progressive modulation of steroid receptor-induced gene transcription.

Qiu Y, Zhao Y, Becker M, John S, Parekh BS, Huang S, Hendarwanto A, Martinez ED, Chen Y, Lu H, Adkins NL, Stavreva DA, Wiench M, Georgel PT, Schiltz RL, Hager GL, Molecular cell, 2006 Jun; 22 (5):669-79

Featured
Loss of androgen receptor transcriptional activity at the G(1)/S transition.

Martinez ED, Danielsen M, The Journal of biological chemistry, 2002 Aug; 277 (33):29719-29

Featured
The Nuclear Receptor Resource: a growing family

Martinez, E., Moore, D., Keller, E., Pearce, D., Vanden Heuvel, J.P., Robinson, V., Gottlieb, B., McDonald, P., Simons, S., Sanchez, E. and Danielsen, M. , Nucleic Acids Res , 1998; (26):239-241

Fluorescent protein-based cellular assays analyzed by laser-scanning microplate cytometry in 1536-well plate format.

Auld DS, Johnson RL, Zhang YQ, Veith H, Jadhav A, Yasgar A, Simeonov A, Zheng W, Martinez ED, Westwick JK, Austin CP, Inglese J, Methods in enzymology, 2006 ; 414:566-89

Development of assays for nuclear receptor modulators using fluorescently tagged proteins.

Martinez ED, Hager GL, Methods in enzymology, 2006 ; 414:37-50

Honors/Awards

Abstract Award

International Association for the Study of Lung Cancer (2007)

NIH Technology Transfer Award

(2004)

NIH FARE Research Excellence Award

(2003)

Keystone Symposia Travel awards

(2002)

Phi Beta Kappa

1994-present

Professional Associations/Affiliations

Co-founder and Member of the Nuclear Receptor Resource Project, 1995-present

Member of the American Association for Cancer Research, 2005-present

Member of the American Society for Cell Biology, 2004-present

Member of the Endocrine Society, 1997-present

NIH Task Force on Recruitment and Retention of Women, Subcommittee co-chair, 2003-present