Steven Altschuler, PhD

Associate Professor
Pharmacology
Graduate Program: Cancer Biology
Cell Regulation
Molecular Biophysics

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

Office Phone: 214-645-6183
Office Fax: 214-645-5965

steven.altschuler@utsouthwestern.edu

Education

Graduate SchoolUniversity of California-San Diego (1990)
Graduate SchoolUniversity of California-San Diego (1990)

Research Interests

Cancer
Cell polarity
Systems biology

Publications

Featured
Image-based multivariate profiling of drug responses from single cells

Loo, L.H., Wu, L., Altschuler, S.J. , Nature Methods , May 2007; (4):445

Featured
On the spontaneous emergence of polarity

Altschuler SJ, Angenent SB, Wang Y, Wu LF , Nature , August 2008; (454):886-890

Featured
Endocytosis optimizes the dynamic localization of membrane proteins that regulate cortical polarity

Marco, E., Wedlich-Soldner, R., Li, R., Altschuler, S.J., Wu, L.F. , Cell , April 2007; (129):411

Featured
Multi-dimensional drug profiling by automated microscopy.

Perlman, Z.E., Slack, M.D., Feng, Y., Mitchison, T.J., Wu, L.F., Altschuler, S.J. , Science , 2004; (306(5699)):1194-1198

Featured
Spontaneous cell polarization through actomyosin-based delivery of the Cdc42 GTPase.

Wedlich-Soldner, R., Altschuler, S.J., Wu, L.F., Li, R. , Science , 2003; (299(5610)):1231-1235

Image-based multivariate profiling of drug responses from single cells

Loo, L.H., Wu, L., Altschuler, S.J. , Nature Methods , May 2007; (4):445

Systems-level analyses identify extensive coupling among gene expression machines

Maciag, K., Altschuler, S.J., Slack, M.D., Krogan, N.J., Emili, A., Greenblatt, J.F., Maniatis, T., Wu, L.F. , Molecular Systems Biology , January 2006; (2):1

On the spontaneous emergence of polarity

Altschuler SJ, Angenent SB, Wang Y, Wu LF , Nature , August 2008; (454):886-890

An actin-based wave generator organizes cell motility

Weiner, O.D., Marganski, W.A., Wu, L.F., Altschuler, S.J., Krischner, M.W. , PLOS Biology , August 2007; (5):221

Endocytosis optimizes the dynamic localization of membrane proteins that regulate cortical polarity

Marco, E., Wedlich-Soldner, R., Li, R., Altschuler, S.J., Wu, L.F. , Cell , April 2007; (129):411

Honors/Awards

Rita Allen Foundation Scholar

Milton E. Cassel Scholar (2008)

UTSW Endowed Scholar

W. W. Caruth, Jr. Scholar in Biomedical Research (2005)

Sloan Foundation

Doctoral Dissertation Fellowship (1989)