Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial Parkinsonism-linked gene DJ-1

Goldberg MS, Pisani A, Haburcak M, Vortherms TA, Kitada T, Costa C, Tong Y, Martella G, Tscherter A, Martins A, Bernardi G, Roth BL, Pothos EN, Calabresi P, Shen J , Neuron , 2005; (45):489-96

Mitochondrial dysfunction and oxidative damage in parkin-deficient mice

Palacino** JJ, Sagi** D, Goldberg** MS, Krauss S, Motz C, Wacker M, Klose J, Shen J , J Biol Chem , 2004; (279):18614-22 **Equal Contribution

alpha-Synuclein is phosphorylated in synucleinopathy lesions

Fujiwara H, Hasegawa M, Dohmae N, Kawashima A, Masliah E, Goldberg MS, Shen J, Takio K, Iwatsubo T , Nat Cell Biol , 2002; (45):160-4

alpha-Synuclein occurs in lipid-rich high molecular weight complexes, binds fatty acids, and shows homology to the fatty acid-binding proteins

Sharon R, Goldberg MS, Bar-Josef I, Betensky RA, Shen J, Selkoe DJ , Proc Natl Acad Sci U S A , 2001; (98):9110-5

Is there a cause-and-effect relationship between alpha-synuclein fibrillization and Parkinson’s disease

Goldberg MS, Lansbury PT Jr. , Nat Cell Biol , 2000; (279):E115-9

Parkin deficiency increases vulnerability to inflammation-induced nigral degeneration

Frank-Cannon TC, Tran T, Ruhn KA, Martinez TN, Hong J, Marvin M Hartley M Trevino I, O’Brien DE Casey B, Goldberg MS, Tansey MG , Journal of Neuroscience , October 2008; (28):10825-34

Regulation of LRRK2 stability by the E3 ubiquitin ligase CHIP

Ding X and Goldberg MS , PLoS ONE , June 2009; (4):e5949

Parkin-mediated ubiquitination regulates phosphlipase C-gamma1

Dehvari N, Sandebring A, Flores-Morales A, Mateos L, Chuan Y-C, Goldberg MS, Cookson MR, Cowburn RF Cedazo-Minguez A , Journal of Cellular and Molecular Medicine , July 2008; (in press)

Increased DJ-1 expression under oxidative stress and in Alzheimer’s disease brains

Baulac S, Lu H, Strahle J, Yang T, Goldberg MS, Shen J, Schlossmacher MG, Lemere CA, Lu Q, Xia W , Molecular Neurodegeneration , February 2009; (4):12

Parkin protects against mitochondrial toxins and beta-amyloid accumulation in skeletal muscle cells

Rosen KM, Veereshwarayya V, Moussa CE, Fu Q, Goldberg MS, Schlossmacher MG, Shen J, Querfurth HW , J Biol Chem , 2006; (281):12809-16